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Search life-sciences literature (45,100,050 articles, preprints and more)

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Cryo-EM structures of the zinc transporters ZnT3 and ZnT4 provide insights into their transport mechanisms.
Ishida H, Yo R, Zhang Z, Shimizu T, Ohto U
FEBS Lett, 30 Oct 2024
Cited by: 0 articles | PMID: 39474773
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2’-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism
Alharbi AS, Sapkota S, Zhang Z, Jin R, Jayasekara WSN, Rupasinghe E, Speir M, Wilkinson-White L, Gamsjaeger R, Cubeddu L, Ellyard JI, Wenholz DS, McAllan AL, Rezwan R, Ying L, Far HH, Bones J, He S, Yu D, [...] Gantier MP
bioRxiv, 25 Jul 2024
Cited by: 0 articles | PPR: PPR886832
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Dexmedetomidine directly binds to and inhibits Toll-like receptor 4.
Koutsogiannaki S, Limratana P, Bu W, Maisat W, McKinstry-Wu A, Han X, Ohto U, Eckenhoff RG, Soriano SG, Yuki K
Int Immunopharmacol, 141:112975, 19 Aug 2024
Cited by: 0 articles | PMID: 39163686
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Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity.
Hirano Y, Ohto U, Ichi I, Sato R, Miyake K, Shimizu T
Commun Biol, 7(1):664, 29 May 2024
Cited by: 2 articles | PMID: 38811802 | PMCID: PMC11137008
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Structural basis of hepatitis B virus receptor binding.
Asami J, Park JH, Nomura Y, Kobayashi C, Mifune J, Ishimoto N, Uemura T, Liu K, Sato Y, Zhang Z, Muramatsu M, Wakita T, Drew D, Iwata S, Shimizu T, Watashi K, Park SY, Nomura N, Ohto U
Nat Struct Mol Biol, 31(3):447-454, 17 Jan 2024
Cited by: 3 articles | PMID: 38233573
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Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome.
Zhang Z, Shibata T, Fujimura A, Kitaura J, Miyake K, Ohto U, Shimizu T
Nature, 622(7981):188-194, 13 Sep 2023
Cited by: 10 articles | PMID: 37704723
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Cryo-EM analysis reveals human SID1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity
Shimizu T, Hirano Y, Ohto U, Sato R, Miyake K
Research Square, 06 Sep 2023
Cited by: 0 articles | PPR: PPR720808
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TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.
Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, [...] Miyake K
J Exp Med, 220(9):e20230054, 18 Jul 2023
Cited by: 2 articles | PMID: 37462944 | PMCID: PMC10354536
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Sphingomyelin d18:1/14:0 activates TLR4 in metaflammation
Latz E, Gorki F, Dohnalová L, Thaiss C, Zurkovic J, Christ A, Ohto U, Marzinek J, Bond PJ, Geißmar E, Singha S, Hamid A, Yaghmour M, de Goede K, Rothe M, Placek K, Polzin A, Wollnitzke P, Levkau B, [...] Bossche JVd
Research Square, 25 Apr 2023
Cited by: 0 articles | PPR: PPR650331
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Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway.
Deguchi A, Watanabe-Takahashi M, Mishima T, Omori T, Ohto U, Arashiki N, Nakamura F, Nishikawa K, Maru Y
Cancer Gene Ther, 30(7):973-984, 17 Mar 2023
Cited by: 1 article | PMID: 36932197 | PMCID: PMC10021052
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TLR7/8 stress response drives histiocytosis in SLC29A3 disorders
Shibata T, Sato R, Taoka M, Saitoh S, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, [...] Miyake K
bioRxiv, 27 Oct 2022
Cited by: 0 articles | PPR: PPR564500
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TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction.
Sakaniwa K, Fujimura A, Shibata T, Shigematsu H, Ekimoto T, Yamamoto M, Ikeguchi M, Miyake K, Ohto U, Shimizu T
Nat Commun, 14(1):164, 11 Jan 2023
Cited by: 7 articles | PMID: 36631495 | PMCID: PMC9834221
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Activation and regulation mechanisms of NOD-like receptors based on structural biology.
Ohto U
Front Immunol, 13:953530, 15 Sep 2022
Cited by: 19 articles | PMID: 36189327 | PMCID: PMC9520476
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Structure of SARS-CoV-2 membrane protein essential for virus assembly.
Zhang Z, Nomura N, Muramoto Y, Ekimoto T, Uemura T, Liu K, Yui M, Kono N, Aoki J, Ikeguchi M, Noda T, Iwata S, Ohto U, Shimizu T
Nat Commun, 13(1):4399, 05 Aug 2022
Cited by: 62 articles | PMID: 35931673 | PMCID: PMC9355944
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Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway
Deguchi A, Watanabe-Takahashi M, Mishima T, Omori T, Ohto U, Nishikawa K, Maru Y
Research Square, 01 Aug 2022
Cited by: 0 articles | PPR: PPR526462
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Propofol directly binds to and inhibits TLR7.
Koutsogiannaki S, Bu W, Maisat W, Manzor M, Zhang Z, Ohto U, Eckenhoff RG, Yuki K
FASEB J, 36(8):e22481, 01 Aug 2022
Cited by: 1 article | PMID: 35899460 | PMCID: PMC9382702
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Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
Ohto U, Kamitsukasa Y, Ishida H, Zhang Z, Murakami K, Hirama C, Maekawa S, Shimizu T
Proc Natl Acad Sci U S A, 119(11):e2121353119, 07 Mar 2022
Cited by: 44 articles | PMID: 35254907 | PMCID: PMC8931350
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Structure of the bile acid transporter and HBV receptor NTCP.
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature, 606(7916):1021-1026, 17 May 2022
Cited by: 32 articles | PMID: 35580629
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The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
Kamitsukasa Y, Nakano K, Murakami K, Hirata K, Yamamoto M, Shimizu T, Ohto U
FEBS Lett, 596(7):876-885, 11 Feb 2022
Cited by: 3 articles | PMID: 35090055
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Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists.
Yang Y, Csakai A, Jiang S, Smith C, Tanji H, Huang J, Jones T, Sakaniwa K, Broadwell L, Shi C, Soti S, Ohto U, Fang Y, Shen S, Deng F, Shimizu T, Yin H
Nat Commun, 12(1):4351, 16 Jul 2021
Cited by: 5 articles | PMID: 34272380 | PMCID: PMC8285539
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Improving particle quality in cryo-EM analysis using a PEGylation method.
Zhang Z, Shigematsu H, Shimizu T, Ohto U
Structure, 29(10):1192-1199.e4, 27 May 2021
Cited by: 13 articles | PMID: 34048698
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Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.
Sakurai S, Shimizu T, Ohto U
Acta Crystallogr F Struct Biol Commun, 76(pt 8):326-333, 28 Jul 2020
Cited by: 4 articles | PMID: 32744243 | PMCID: PMC7397462
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Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Ishida H, Asami J, Zhang Z, Nishizawa T, Shigematsu H, Ohto U, Shimizu T
Nat Struct Mol Biol, 28(2):173-180, 11 Jan 2021
Cited by: 36 articles | PMID: 33432245
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Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains.
Masutani M, Sakurai S, Shimizu T, Ohto U
FEBS Lett, 594(18):3020-3031, 14 Jul 2020
Cited by: 4 articles | PMID: 32608065
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The effect of anesthetics on toll like receptor 9.
Koutsogiannaki S, Bu W, Hou L, Shibamura-Fujiogi M, Ishida H, Ohto U, Eckenhoff RG, Yuki K
FASEB J, 34(11):14645-14654, 09 Sep 2020
Cited by: 4 articles | PMID: 32901993 | PMCID: PMC7814252
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