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Search life-sciences literature (45,100,050 articles, preprints and more)

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Molecular determinants of neuropeptide-mediated activation mechanisms in tachykinin NK1 and NK2 receptors.
Petersen JE, Pavlovskyi A, Madsen JJ, Schwartz TW, Frimurer TM, Olsen OH
J Biol Chem, 107948, 29 Oct 2024
Cited by: 0 articles | PMID: 39481599
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The intricate allostery in factor VIIa: triggering the trigger.
Madsen JJ, Persson E, Olsen OH
J Thromb Haemost, S1538-7836(24)00551-8, 26 Sep 2024
Cited by: 0 articles | PMID: 39332529
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A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders.
Gandhi PS, Zivkovic M, Østergaard H, Bonde AC, Elm T, Løvgreen MN, Schluckebier G, Johansson E, Olsen OH, Olsen EHN, de Bus IA, Bloem K, Alskär O, Rea CJ, Bjørn SE, Schutgens RE, Sørensen B, Urbanus RT, Faber JH
Nat Cardiovasc Res, 3(2):166-185, 08 Feb 2024
Cited by: 1 article | PMID: 39196196 | PMCID: PMC11358003
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Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors.
Madsen JJ, Petersen JE, Christensen DP, Hansen JB, Schwartz TW, Frimurer TM, Olsen OH
J Biol Chem, 299(12):105438, 07 Nov 2023
Cited by: 0 articles | PMID: 37944618 | PMCID: PMC10724690
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Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures.
Madsen JJ, Ye L, Frimurer TM, Olsen OH
Protein Sci, 31(11):e4456, 01 Nov 2022
Cited by: 4 articles | PMID: 36134696 | PMCID: PMC9601807
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A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa.
Sorensen AB, Greisen PJ, Madsen JJ, Lund J, Andersen G, Wulff-Larsen PG, Pedersen AA, Gandhi PS, Overgaard MT, Østergaard H, Olsen OH
Sci Rep, 12(1):3747, 08 Mar 2022
Cited by: 2 articles | PMID: 35260627 | PMCID: PMC8904457
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The functional role of the autolysis loop in the regulation of factor X upon hemostatic response.
Bonde AC, Lund J, Hansen JJ, Winther JR, Nielsen PF, Zahn S, Tiainen P, Olsen OH, Petersen HH, Bjelke JR
J Thromb Haemost, 20(3):589-599, 03 Jan 2022
Cited by: 1 article | PMID: 34927362
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Prolonging coagulant activity of factor Xa under hemophilic conditions by site-specific N-glycosylation of the surface-exposed autolysis loop
Bonde AC, Lund J, Hansen JJ, Winther JR, Zahn S, Tiainen P, Olsen OH, Petersen HH, Bjelke JR
bioRxiv, 01 Jul 2021
Cited by: 0 articles | PPR: PPR364853
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Conformational Plasticity-Rigidity Axis of the Coagulation Factor VII Zymogen Elucidated by Atomistic Simulations of the N-Terminally Truncated Factor VIIa Protease Domain.
Madsen JJ, Olsen OH
Biomolecules, 11(4):549, 08 Apr 2021
Cited by: 3 articles | PMID: 33917935 | PMCID: PMC8068379
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Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.
Sorensen AB, Tuneew I, Svensson LA, Persson E, Østergaard H, Overgaard MT, Olsen OH, Gandhi PS
J Biol Chem, 295(2):517-528, 04 Dec 2019
Cited by: 5 articles | PMID: 31801825 | PMCID: PMC6956519
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Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures.
Sorensen AB, Madsen JJ, Frimurer TM, Overgaard MT, Gandhi PS, Persson E, Olsen OH
Biophys J, 116(10):1823-1835, 02 Apr 2019
Cited by: 6 articles | PMID: 31003762 | PMCID: PMC6531671
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Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey: comment.
Madsen JJ, Persson E, Olsen OH
J Thromb Haemost, 16(7):1450-1454, 06 Jun 2018
Cited by: 3 articles | PMID: 29733494
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Engineering of a membrane-triggered activity switch in coagulation factor VIIa.
Nielsen AL, Sorensen AB, Holmberg HL, Gandhi PS, Karlsson J, Buchardt J, Lamberth K, Kjelgaard-Hansen M, Ley CD, Sørensen BB, Ruf W, Olsen OH, Østergaard H
Proc Natl Acad Sci U S A, 114(47):12454-12459, 06 Nov 2017
Cited by: 5 articles | PMID: 29109275 | PMCID: PMC5703266
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Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.
Kristensen LH, Olsen OH, Blouse GE, Brandstetter H
Biochem J, 473(15):2395-2411, 19 May 2016
Cited by: 7 articles | PMID: 27208168
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Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.
Sorensen AB, Madsen JJ, Svensson LA, Pedersen AA, Østergaard H, Overgaard MT, Olsen OH, Gandhi PS
J Biol Chem, 291(9):4671-4683, 22 Dec 2015
Cited by: 13 articles | PMID: 26694616 | PMCID: PMC4813490
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Membrane Interaction of the Factor VIIIa Discoidin Domains in Atomistic Detail.
Madsen JJ, Ohkubo YZ, Peters GH, Faber JH, Tajkhorshid E, Olsen OH
Biochemistry, 54(39):6123-6131, 30 Sep 2015
Cited by: 15 articles | PMID: 26346528 | PMCID: PMC5050047
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Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.
van den Biggelaar M, Madsen JJ, Faber JH, Zuurveld MG, van der Zwaan C, Olsen OH, Stennicke HR, Mertens K, Meijer AB
J Biol Chem, 290(27):16463-16476, 21 Apr 2015
Cited by: 18 articles | PMID: 25903134 | PMCID: PMC4505400
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Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.
Lund J, Troeberg L, Kjeldal H, Olsen OH, Nagase H, Sørensen ES, Stennicke HR, Petersen HH, Overgaard MT
J Biol Chem, 290(10):6620-6629, 06 Jan 2015
Cited by: 7 articles | PMID: 25564618 | PMCID: PMC4358294
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The length of the linker between the epidermal growth factor-like domains in factor VIIa is critical for a productive interaction with tissue factor.
Persson E, Madsen JJ, Olsen OH
Protein Sci, 23(12):1717-1727, 14 Oct 2014
Cited by: 5 articles | PMID: 25234571 | PMCID: PMC4253812
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Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry.
Song H, Olsen OH, Persson E, Rand KD
J Biol Chem, 289(51):35388-35396, 24 Oct 2014
Cited by: 13 articles | PMID: 25344622 | PMCID: PMC4271224
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Tissue factor activates allosteric networks in factor VIIa through structural and dynamic changes.
Madsen JJ, Persson E, Olsen OH
J Thromb Haemost, 13(2):262-267, 12 Dec 2014
Cited by: 15 articles | PMID: 25403348
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ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity.
Lund J, Olsen OH, Sørensen ES, Stennicke HR, Petersen HH, Overgaard MT
J Biol Chem, 288(29):21367-21375, 10 Jun 2013
Cited by: 17 articles | PMID: 23754285 | PMCID: PMC3774404
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Evaluation of the metal binding sites in a recombinant coagulation factor VIII identifies two sites with unique metal binding properties.
Svensson LA, Thim L, Olsen OH, Nicolaisen EM
Biol Chem, 394(6):761-765, 01 Jun 2013
Cited by: 17 articles | PMID: 23435097
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Vatreptacog alfa from conception to clinical proof of concept.
Persson E, Olsen OH, Bjørn SE, Ezban M
Semin Thromb Hemost, 38(3):274-281, 18 Feb 2012
Cited by: 10 articles | PMID: 22510860
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Allosteric activation of coagulation factor VIIa.
Persson E, Olsen OH
Front Biosci (Landmark Ed), 16(8):3156-3163, 01 Jun 2011
Cited by: 14 articles | PMID: 21622226
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