AUTH:"Prange KHM" - Search results

Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans.

Diez Benavente E, Hartman RJG, Sakkers TR, Wesseling M, Sloots Y, Slenders L, Boltjes A, Mol BM, de Borst GJ, de Kleijn DPV, Prange KHM, de Winther MPJ, Kuiper J, Civelek M, van der Laan SW, Horvath S, Onland-Moret NC, Mokry M, Pasterkamp G, den Ruijter HM

Arterioscler Thromb Vasc Biol, 44(6):1419-1431, 18 Apr 2024

Cited by: 0 articles | PMID: 38634280

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Infiltrative classical monocyte-derived andSPP1lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis

Vegting Y, Jongejan A, Neele AE, Claessen N, Sela G, Prange KHM, Kers J, Roelofs JJTH, van der Heijden JW, de Boer OJ, Remmerswaal EBM, Vogt L, Bemelman FJ, de Winther MPJ, Moerland PD, Hilhorst ML

bioRxiv, 13 Mar 2024

Cited by: 0 articles | PPR: PPR822702

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Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation.

Dzobo KE, Cupido AJ, Mol BM, Stiekema LCA, Versloot M, Winkelmeijer M, Peter J, Pennekamp AM, Havik SR, Vaz FM, van Weeghel M, Prange KHM, Levels JHM, de Winther MPJ, Tsimikas S, Groen AK, Stroes ESG, de Kleijn DPV, Kroon J

Arterioscler Thromb Vasc Biol, 44(3):720-740, 25 Jan 2024

Cited by: 3 articles | PMID: 38269588 | PMCID: PMC10880937

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Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic Plaques.

Diez Benavente E, Karnewar S, Buono M, Mili E, Hartman RJG, Kapteijn D, Slenders L, Daniels M, Aherrahrou R, Reinberger T, Mol BM, de Borst GJ, de Kleijn DPV, Prange KHM, Depuydt MAC, de Winther MPJ, Kuiper J, Björkegren JLM, Erdmann J, [...] den Ruijter HM

Arterioscler Thromb Vasc Biol, 43(10):1836-1850, 17 Aug 2023

Cited by: 3 articles | PMID: 37589136 | PMCID: PMC10521798

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Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation.

Mokry M, Boltjes A, Slenders L, Bel-Bordes G, Cui K, Brouwer E, Mekke JM, Depuydt MAC, Timmerman N, Waissi F, Verwer MC, Turner AW, Khan MD, Hodonsky CJ, Benavente ED, Hartman RJG, van den Dungen NAM, Lansu N, Nagyova E, [...] Pasterkamp G

Nat Cardiovasc Res, 1(12):1140-1155, 12 Dec 2022

Cited by: 10 articles | PMID: 37920851 | PMCID: PMC10621615

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Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques

Benavente ED, Karnewar S, Buono M, Mili E, Hartman RJG, Kapteijn D, Slenders L, Daniels M, Aherrahrou R, Reinberger T, Mol BM, de Borst GJ, de Kleijn DPV, Prange KHM, Depuydt MAC, de Winther MPJ, Kuiper J, Björkegren JLM, Erdmann J, [...] den Ruijter HM

bioRxiv, 11 Feb 2023

Cited by: 0 articles | PPR: PPR615511

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Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells.

Depuydt MAC, Schaftenaar FH, Prange KHM, Boltjes A, Hemme E, Delfos L, de Mol J, de Jong MJM, Bernabé Kleijn MNA, Peeters JAHM, Goncalves L, Wezel A, Smeets HJ, de Borst GJ, Foks AC, Pasterkamp G, de Winther MPJ, Kuiper J, Bot I, Slütter B

Nat Cardiovasc Res, 2(2):112-125, 30 Jan 2023

Cited by: 24 articles | PMID: 38665903 | PMCID: PMC11041750

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Atherosclerotic plaque epigenetic age acceleration is characterized by mesenchymal reprogramming and poor prognosis

Hartman RJG, Benavente ED, Slenders L, Boltjes A, Mol BM, de Borst GJ, de Kleijn DPV, Prange KHM, de Winther MPJ, Kuiper J, Civelek M, van der Laan SW, Horvath S, Onland-Moret C, Mokry M, Pasterkamp G, den Ruijter HM

medRxiv, 18 Feb 2023

Cited by: 0 articles | PPR: PPR618479

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DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.

Willemsen L, Prange KHM, Neele AE, van Roomen CPAA, Gijbels M, Griffith GR, Toom MD, Beckers L, Siebeler R, Spann NJ, Chen HJ, Bosmans LA, Gorbatenko A, van Wouw S, Zelcer N, Jacobs H, van Leeuwen F, de Winther MPJ

Cell Rep, 41(8):111703, 01 Nov 2022

Cited by: 7 articles | PMID: 36417856

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Impact of cholesterol on proinflammatory monocyte production by the bone marrow.

Stiekema LCA, Willemsen L, Kaiser Y, Prange KHM, Wareham NJ, Boekholdt SM, Kuijk C, de Winther MPJ, Voermans C, Nahrendorf M, Stroes ESG, Kroon J

Eur Heart J, 42(42):4309-4320, 01 Nov 2021

Cited by: 20 articles | PMID: 34343254 | PMCID: PMC8572558

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Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis.

Slenders L, Landsmeer LPL, Cui K, Depuydt MAC, Verwer M, Mekke J, Timmerman N, van den Dungen NAM, Kuiper J, de Winther MPJ, Prange KHM, Ma WF, Miller CL, Aherrahrou R, Civelek M, de Borst GJ, de Kleijn DPV, Asselbergs FW, den Ruijter HM, [...] Mokry M

Eur Heart J Open, 2(1):oeab043, 21 Dec 2021

Cited by: 24 articles | PMID: 35174364 | PMCID: PMC8841481

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Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease.

Lacy M, Bürger C, Shami A, Ahmadsei M, Winkels H, Nitz K, van Tiel CM, Seijkens TTP, Kusters PJH, Karshovka E, Prange KHM, Wu Y, Brouns SLN, Unterlugauer S, Kuijpers MJE, Reiche ME, Steffens S, Edsfeldt A, Megens RTA, [...] Lutgens E

Nat Commun, 12(1):3754, 18 Jun 2021

Cited by: 36 articles | PMID: 34145241 | PMCID: PMC8213756

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Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.

Depuydt MAC, Prange KHM, Slenders L, Örd T, Elbersen D, Boltjes A, de Jager SCA, Asselbergs FW, de Borst GJ, Aavik E, Lönnberg T, Lutgens E, Glass CK, den Ruijter HM, Kaikkonen MU, Bot I, Slütter B, van der Laan SW, Yla-Herttuala S, [...] Pasterkamp G

Circ Res, 127(11):1437-1455, 28 Sep 2020

Cited by: 231 articles | PMID: 32981416 | PMCID: PMC7641189

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Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques.

Baardman J, Verberk SGS, van der Velden S, Gijbels MJJ, van Roomen CPPA, Sluimer JC, Broos JY, Griffith GR, Prange KHM, van Weeghel M, Lakbir S, Molenaar D, Meinster E, Neele AE, Kooij G, de Vries HE, Lutgens E, Wellen KE, de Winther MPJ, Van den Bossche J

Nat Commun, 11(1):6296, 08 Dec 2020

Cited by: 64 articles | PMID: 33293558 | PMCID: PMC7722882

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Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotein(a).

Stiekema LCA, Prange KHM, Hoogeveen RM, Verweij SL, Kroon J, Schnitzler JG, Dzobo KE, Cupido AJ, Tsimikas S, Stroes ESG, de Winther MPJ, Bahjat M

Eur Heart J, 41(24):2262-2271, 01 Jun 2020

Cited by: 40 articles | PMID: 32268367 | PMCID: PMC7308540

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Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss.

Willemsen L, Neele AE, van der Velden S, Prange KHM, den Toom M, van Roomen CPAA, Reiche ME, Griffith GR, Gijbels MJJ, Lutgens E, de Winther MPJ

BMJ Open Diabetes Res Care, 7(1):e000751, 02 Nov 2019

Cited by: 4 articles | PMID: 31798899 | PMCID: PMC6861071

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Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation.

Schnitzler JG, Hoogeveen RM, Ali L, Prange KHM, Waissi F, van Weeghel M, Bachmann JC, Versloot M, Borrelli MJ, Yeang C, De Kleijn DPV, Houtkooper RH, Koschinsky ML, de Winther MPJ, Groen AK, Witztum JL, Tsimikas S, Stroes ESG, Kroon J

Circ Res, 126(10):1346-1359, 12 Mar 2020

Cited by: 63 articles | PMID: 32160811 | PMCID: PMC7208285

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Transcriptional and epigenetic regulation of macrophages in atherosclerosis.

Kuznetsova T, Prange KHM, Glass CK, de Winther MPJ

Nat Rev Cardiol, 17(4):216-228, 02 Oct 2019

Cited by: 141 articles | PMID: 31578516 | PMCID: PMC7770754

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Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes.

Yi G, Wierenga ATJ, Petraglia F, Narang P, Janssen-Megens EM, Mandoli A, Merkel A, Berentsen K, Kim B, Matarese F, Singh AA, Habibi E, Prange KHM, Mulder AB, Jansen JH, Clarke L, Heath S, van der Reijden BA, Flicek P, [...] Martens JHA

Cell Rep, 26(4):1059-1069.e6, 01 Jan 2019

Cited by: 21 articles | PMID: 30673601 | PMCID: PMC6363099

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A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.

Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wüst RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'neill LA, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J

Cell Rep, 25(8):2044-2052.e5, 01 Nov 2018

Cited by: 94 articles | PMID: 30463003

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Myeloid Kdm6b deficiency results in advanced atherosclerosis.

Neele AE, Gijbels MJJ, van der Velden S, Hoeksema MA, Boshuizen MCS, Prange KHM, Chen HJ, Van den Bossche J, van Roomen CPPA, Shami A, Levels JHM, Kroon J, Lucas T, Dimmeler S, Lutgens E, de Winther MPJ

Atherosclerosis, 275:156-165, 01 Jun 2018

Cited by: 17 articles | PMID: 29908485

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C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation.

Marneth AE, Prange KHM, Al Hinai ASA, Bergevoet SM, Tesi N, Janssen-Megens EM, Kim B, Sharifi N, Yaspo ML, Kuster J, Sanders MA, Stoetman ECG, Knijnenburg J, Arentsen-Peters TCJM, Zwaan CM, Stunnenberg HG, van den Heuvel-Eibrink MM, Haferlach T, Fornerod M, [...] Martens JHA

Leukemia, 32(3):828-836, 05 Sep 2017

Cited by: 3 articles | PMID: 28871137

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MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.

Prange KHM, Mandoli A, Kuznetsova T, Wang SY, Sotoca AM, Marneth AE, van der Reijden BA, Stunnenberg HG, Martens JHA

Oncogene, 36(23):3346-3356, 23 Jan 2017

Cited by: 60 articles | PMID: 28114278 | PMCID: PMC5474565

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The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs.

Mandoli A, Singh AA, Prange KHM, Tijchon E, Oerlemans M, Dirks R, Ter Huurne M, Wierenga ATJ, Janssen-Megens EM, Berentsen K, Sharifi N, Kim B, Matarese F, Nguyen LN, Hubner NC, Rao NA, van den Akker E, Altucci L, Vellenga E, [...] Martens JHA

Cell Rep, 17(8):2087-2100, 01 Nov 2016

Cited by: 40 articles | PMID: 27851970

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Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans.

Infiltrative classical monocyte-derived andSPP1lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis

Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation.

Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic Plaques.

Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation.

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques

Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells.

Atherosclerotic plaque epigenetic age acceleration is characterized by mesenchymal reprogramming and poor prognosis

DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.

Impact of cholesterol on proinflammatory monocyte production by the bone marrow.

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis.

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease.

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques.

Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotein(a).

Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss.

Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation.

Transcriptional and epigenetic regulation of macrophages in atherosclerosis.

Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes.

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.

Myeloid Kdm6b deficiency results in advanced atherosclerosis.

C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation.

MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs.

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