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Phase 1 Study of ROR1 Specific CAR T Cells in Advanced Hematopoietic and Epithelial Malignancies.
Jaeger-Ruckstuhl CA, Specht JM, Voutsinas JM, MacMillan HR, Wu QV, Muhunthan V, Berger C, Pullarkat S, Wright JH, Yeung CCS, Hyun TS, Seaton B, Aicher LD, Song X, Pierce RH, Lo Y, Cole GO, Lee SM, Newell EW, [...] Riddell SR
Clin Cancer Res, 28 Oct 2024
Cited by: 0 articles | PMID: 39466024
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Single-cell analysis of the multiple myeloma microenvironment after gamma-secretase inhibition and CAR T-cell therapy.
Coffey DG, Atilla PA, Atilla E, Landgren O, Cowan AJ, Simon S, Pont M, Comstock ML, Hill GR, Riddell SR, Green DJ
Blood, blood.2024025231, 07 Oct 2024
Cited by: 0 articles | PMID: 39374522
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Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion.
Fiorenza S, Zheng Y, Purushe J, Bock TJ, Sarthy J, Janssens DH, Sheih AS, Kimble EL, Kirchmeier D, Phi TD, Gauthier J, Hirayama AV, Riddell SR, Wu Q, Gottardo R, Maloney DG, Yang JYH, Henikoff S, Turtle CJ
Nat Commun, 15(1):8309, 27 Sep 2024
Cited by: 0 articles | PMID: 39333103 | PMCID: PMC11436946
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HA-1-targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation.
Krakow EF, Brault M, Summers C, Cunningham TM, Biernacki MA, Black RG, Woodward KB, Vartanian N, Kanaan SB, Yeh AC, Dossa RG, Bar M, Cassaday RD, Dahlberg A, Till BG, Denker AE, Yeung CCS, Gooley TA, Maloney DG, [...] Bleakley M
Blood, 144(10):1069-1082, 01 Sep 2024
Cited by: 2 articles | PMID: 38683966
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CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.
Le Q, Hadland B, Smith JL, Leonti A, Huang BJ, Ries R, Hylkema TA, Castro S, Tang TT, McKay CN, Perkins L, Pardo L, Sarthy J, Beckman AK, Williams R, Idemmili R, Furlan S, Ishida T, Call L, [...] Meshinchi S
J Clin Invest, 134(16):e184305, 15 Aug 2024
Cited by: 0 articles | PMID: 39145456 | PMCID: PMC11324293
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CARs derived from broadly neutralizing, human monoclonal antibodies identified by single B cell sorting target hepatitis B virus-positive cells.
Schreiber S, Dressler LS, Loffredo-Verde E, Asen T, Färber S, Wang W, Groll T, Chakraborty A, Kolbe F, Kreer C, Kosinska AD, Simon S, Urban S, Klein F, Riddell SR, Protzer U
Front Immunol, 15:1340619, 22 Apr 2024
Cited by: 1 article | PMID: 38711498 | PMCID: PMC11072186
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TIM-3⁺ CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies.
Minnie SA, Waltner OG, Zhang P, Takahashi S, Nemychenkov NS, Ensbey KS, Schmidt CR, Legg SRW, Comstock M, Boiko JR, Nelson E, Bhise SS, Wilkens AB, Koyama M, Dhodapkar MV, Chesi M, Riddell SR, Green DJ, Spencer A, [...] Hill GR
Sci Immunol, 9(94):eadg1094, 19 Apr 2024
Cited by: 5 articles | PMID: 38640253
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Systemically administered low-affinity HER2 CAR T cells mediate antitumor efficacy without toxicity.
Shabaneh TB, Stevens AR, Stull SM, Shimp KR, Seaton BW, Gad EA, Jaeger-Ruckstuhl CA, Simon S, Koehne AL, Price JP, Olson JM, Hoffstrom BG, Jellyman D, Riddell SR
J Immunother Cancer, 12(2):e008566, 07 Feb 2024
Cited by: 3 articles | PMID: 38325903 | PMCID: PMC11145640
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A chimeric antigen receptor-based cellular safeguard mechanism for selective <i>in vivo</i> depletion of engineered T cells.
Svec M, Dötsch S, Warmuth L, Trebo M, Fräßle S, Riddell SR, Jäger U, D'Ippolito E, Busch DH
Front Immunol, 14:1268698, 11 Jan 2024
Cited by: 0 articles | PMID: 38274808 | PMCID: PMC10808742
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Timing of anti-PD-L1 antibody initiation affects efficacy/toxicity of CD19 CAR T-cell therapy for large B-cell lymphoma.
Hirayama AV, Kimble EL, Wright JH, Fiorenza S, Gauthier J, Voutsinas JM, Wu Q, Yeung CCS, Gazeau N, Pender BS, Kirchmeier DR, Torkelson A, Chutnik AN, Cassaday RD, Chapuis AG, Green DJ, Kiem HP, Milano F, Shadman M, [...] Turtle CJ
Blood Adv, 8(2):453-467, 01 Jan 2024
Cited by: 5 articles | PMID: 37903325 | PMCID: PMC10837185
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Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.
Jaeger-Ruckstuhl CA, Lo Y, Fulton E, Waltner OG, Shabaneh TB, Simon S, Muthuraman PV, Correnti CE, Newsom OJ, Engstrom IA, Kanaan SB, Bhise SS, Peralta JMC, Ruff R, Price JP, Stull SM, Stevens AR, Bugos G, Kluesner MG, [...] Riddell SR
Immunity, 57(2):287-302.e12, 01 Feb 2024
Cited by: 1 article | PMID: 38354704
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Immune evasion of dormant disseminated tumor cells is due to their scarcity and can be overcome by T cell immunotherapies.
Goddard ET, Linde MH, Srivastava S, Klug G, Shabaneh TB, Iannone S, Grzelak CA, Marsh S, Riggio AI, Shor RE, Linde IL, Guerrero M, Veatch JR, Snyder AG, Welm AL, Riddell SR, Ghajar CM
Cancer Cell, 42(1):119-134.e12, 01 Jan 2024
Cited by: 9 articles | PMID: 38194912
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Factors associated with long-term outcomes of CD19 CAR T-cell therapy for relapsed/refractory CLL.
Liang EC, Albittar A, Huang JJ, Hirayama AV, Kimble EL, Portuguese AJ, Chapuis A, Shadman M, Till BG, Cassaday RD, Milano F, Kiem HP, Riddell SR, Turtle CJ, Maloney DG, Gauthier J
Blood Adv, 7(22):6990-7005, 01 Nov 2023
Cited by: 3 articles | PMID: 37774014 | PMCID: PMC10690558
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Toll-Like Receptor 4 Agonist Injection With Concurrent Radiotherapy in Patients With Metastatic Soft Tissue Sarcoma: A Phase 1 Nonrandomized Controlled Trial.
Seo YD, Lu H, Black G, Smythe K, Yu Y, Hsu C, Ng J, Hermida de Viveiros P, Warren EH, Schroeder BA, O'Malley RB, Cranmer LD, Loggers ET, Wagner MJ, Bonham L, Pillarisetty VG, Kane G, Berglund P, Hsu FJ, [...] Pollack SM
JAMA Oncol, 9(12):1660-1668, 01 Dec 2023
Cited by: 9 articles | PMID: 37824131 | PMCID: PMC10570919
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Stem-cell-like CD4⁺ T cells prey on MHC class II-negative tumors.
Veatch JR, Riddell SR
Nat Immunol, 24(8):1212-1214, 01 Aug 2023
Cited by: 0 articles | PMID: 37460640
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Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function.
Leung I, Templeton ML, Lo Y, Rajan A, Stull SM, Garrison SM, Salter AI, Smythe KS, Correnti CE, Srivastava S, Yeung CCS, Riddell SR
Blood Adv, 7(12):2718-2730, 01 Jun 2023
Cited by: 5 articles | PMID: 36469024 | PMCID: PMC10275707
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γ-Secretase inhibitor in combination with BCMA chimeric antigen receptor T-cell immunotherapy for individuals with relapsed or refractory multiple myeloma: a phase 1, first-in-human trial.
Cowan AJ, Pont MJ, Sather BD, Turtle CJ, Till BG, Libby EN, Coffey DG, Tuazon SA, Wood B, Gooley T, Wu VQ, Voutsinas J, Song X, Shadman M, Gauthier J, Chapuis AG, Milano F, Maloney DG, Riddell SR, Green DJ
Lancet Oncol, 24(7):811-822, 01 Jul 2023
Cited by: 18 articles | PMID: 37414012
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A novel polymer-conjugated human IL-15 improves efficacy of CD19-targeted CAR T-cell immunotherapy.
Hirayama AV, Chou CK, Miyazaki T, Steinmetz RN, Di HA, Fraessle SP, Gauthier J, Fiorenza S, Hawkins RM, Overwijk WW, Riddell SR, Marcondes MQ, Turtle CJ
Blood Adv, 7(11):2479-2493, 01 Jun 2023
Cited by: 6 articles | PMID: 36332004 | PMCID: PMC10242497
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CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.
Le Q, Hadland B, Smith JL, Leonti A, Huang BJ, Ries R, Hylkema TA, Castro S, Tang TT, McKay CN, Perkins L, Pardo L, Sarthy J, Beckman AK, Williams R, Idemmili R, Furlan S, Ishida T, Call L, [...] Meshinchi S
J Clin Invest, 132(22):e157101, 15 Nov 2022
Cited by: 18 articles | PMID: 36136600 | PMCID: PMC9663156
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A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy.
Quijano-Rubio A, Bhuiyan AM, Yang H, Leung I, Bello E, Ali LR, Zhangxu K, Perkins J, Chun JH, Wang W, Lajoie MJ, Ravichandran R, Kuo YH, Dougan SK, Riddell SR, Spangler JB, Dougan M, Silva DA, Baker D
Nat Biotechnol, 41(4):532-540, 31 Oct 2022
Cited by: 19 articles | PMID: 36316485 | PMCID: PMC10110466
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NOTCH1 signaling during CD4+ T-cell activation alters transcription factor networks and enhances antigen responsiveness.
Wilkens AB, Fulton EC, Pont MJ, Cole GO, Leung I, Stull SM, Hart MR, Bernstein ID, Furlan SN, Riddell SR
Blood, 140(21):2261-2275, 01 Nov 2022
Cited by: 8 articles | PMID: 35605191 | PMCID: PMC9837446
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Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours.
Flugel CL, Majzner RG, Krenciute G, Dotti G, Riddell SR, Wagner DL, Abou-El-Enein M
Nat Rev Clin Oncol, 20(1):49-62, 23 Nov 2022
Cited by: 94 articles | PMID: 36418477 | PMCID: PMC10278599
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Safety switch optimization enhances antibody-mediated elimination of CAR T cells.
Shabaneh TB, Moffett HF, Stull SM, Derezes T, Tait LJ, Park S, Riddell SR, Lajoie MJ
Front Mol Med, 2:1026474, 11 Oct 2022
Cited by: 2 articles | PMID: 39086975 | PMCID: PMC11285702
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Safety switch optimization enhances antibody-mediated elimination of CAR T cells
Shabaneh TB, Moffett HF, Stull SM, Derezes T, Tait LJ, Park S, Riddell SR, Lajoie MJ
bioRxiv, 24 Aug 2022
Cited by: 0 articles | PPR: PPR535973
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Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity.
Güner G, Aßfalg M, Zhao K, Dreyer T, Lahiri S, Lo Y, Slivinschi BI, Imhof A, Jocher G, Strohm L, Behrends C, Langosch D, Bronger H, Nimsky C, Bartsch JW, Riddell SR, Steiner H, Lichtenthaler SF
EMBO Mol Med, 14(10):e16084, 07 Sep 2022
Cited by: 2 articles | PMID: 36069059 | PMCID: PMC9549706
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