AUTH:"Sacramento CQ" - Search results

Anti-PF4 positivity and platelet activation after Ad26.COV2·S vaccination in Brazil.

Bokel J, Martins-Gonçalves R, Grinsztejn E, Mendes-de-Almeida DP, Hoagland B, Cardoso SW, Geraldo KM, Coutinho SN, Georg I, Oliveira MH, Dos Santos Souza F, Sacramento CQ, Rozini SV, Vizzoni AG, Veloso V, Bozza PT, Grinsztejn B

Vaccine, 42(25):126175, 05 Aug 2024

Cited by: 0 articles | PMID: 39107160

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Extracellular vesicles from primary human macrophages stimulated with VIP or PACAP mediate anti-SARS-CoV-2 activities in monocytes through NF-κB signaling pathway.

Arteaga-Blanco LA, Temerozo JR, Tiné LPS, Dantas-Pereira L, Sacramento CQ, Fintelman-Rodrigues N, Toja BM, Gomes Dias SS, de Freitas CS, Espírito-Santo CC, Silva YP, Frozza RL, Bozza PT, Menna-Barreto RFS, Souza TML, Bou-Habib DC

Microbes Infect, 105400, 26 Jul 2024

Cited by: 0 articles | PMID: 39069117

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Unveiling the Antiviral Capabilities of Targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2.

Purificação AD, Silva-Mendonça S, Cruz LV, Sacramento CQ, Temerozo JR, Fintelman-Rodrigues N, de Freitas CS, Godoi BF, Vaidergorn MM, Leite JA, Salazar Alvarez LC, Freitas MV, Silvac MFB, Martin BA, Lopez RFV, Neves BJ, Costa FTM, Souza TML, da Silva Emery F, [...] Nonato MC

ACS Omega, 9(10):11418-11430, 28 Feb 2024

Cited by: 1 article | PMID: 38496952 | PMCID: PMC10938441

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Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2

Purificação AD, Mendonça SS, Cruz LV, Sacramento CQ, Temerozo JR, Fintelman-Rodrigues N, Souza de Freitas C, Godoi BF, Vaidergorn MM, Leite JA, Salazar Alvarez LC, Freitas MV, Silva MFB, Martin BA, Lopez RFV, Neves BJ, Costa FTM, Souza TML, Emery FdS, [...] Nonato MC

bioRxiv, 05 Oct 2023

Cited by: 0 articles | PPR: PPR736682

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Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.

Soares VC, Dias SSG, Santos JC, Azevedo-Quintanilha IG, Moreira IBG, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, da Silva MAN, Barreto-Vieira DF, Souza TM, Bozza PT

Life Sci Alliance, 6(11):e202302049, 05 Sep 2023

Cited by: 5 articles | PMID: 37669865 | PMCID: PMC10481517

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Severe influenza infection is associated with inflammatory programmed cell death in infected macrophages.

Ferreira AC, Sacramento CQ, Pereira-Dutra FS, Fintelman-Rodrigues N, Silva PP, Mattos M, de Freitas CS, Marttorelli A, de Melo GR, Campos MM, Azevedo-Quintanilha IG, Carlos AS, Emídio JV, Garcia CC, Bozza PT, Bozza FA, Souza TML

Front Cell Infect Microbiol, 13:1067285, 16 Feb 2023

Cited by: 6 articles | PMID: 36875528 | PMCID: PMC9980436

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Dengue induces iNOS expression and nitric oxide synthesis in platelets through IL-1R.

Pinheiro MBM, Rozini SV, Quirino-Teixeira AC, Barbosa-Lima G, Lopes JF, Sacramento CQ, Bozza FA, Bozza PT, Hottz ED

Front Immunol, 13:1029213, 07 Dec 2022

Cited by: 5 articles | PMID: 36569864 | PMCID: PMC9767985

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Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation.

Souza TML, Pinho VD, Setim CF, Sacramento CQ, Marcon R, Fintelman-Rodrigues N, Chaves OA, Heller M, Temerozo JR, Ferreira AC, Mattos M, Momo PB, Dias SSG, Gesto JSM, Pereira-Dutra F, Viola JPB, Queiroz-Junior CM, Guimarães LC, Chaves IM, [...] Rabi JA

Nat Commun, 14(1):199, 13 Jan 2023

Cited by: 4 articles | PMID: 36639383 | PMCID: PMC9837764

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Agathisflavone, a natural biflavonoid that inhibits SARS-CoV-2 replication by targeting its proteases.

Chaves OA, Lima CR, Fintelman-Rodrigues N, Sacramento CQ, de Freitas CS, Vazquez L, Temerozo JR, Rocha MEN, Dias SSG, Carels N, Bozza PT, Castro-Faria-Neto HC, Souza TML

Int J Biol Macromol, 222(pt a):1015-1026, 29 Sep 2022

Cited by: 11 articles | PMID: 36183752 | PMCID: PMC9525951

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Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19.

Hottz ED, Martins-Gonçalves R, Palhinha L, Azevedo-Quintanilha IG, de Campos MM, Sacramento CQ, Temerozo JR, Soares VC, Dias SSG, Teixeira L, Castro Í, Righy C, Souza TML, Kurtz P, Andrade BB, Nakaya HI, Monteiro RQ, Bozza FA, Bozza PT

Blood Adv, 6(17):5085-5099, 01 Sep 2022

Cited by: 28 articles | PMID: 35420680 | PMCID: PMC9015715

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Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication and its major protease in a non-competitive way.

Chaves OA, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, Pereira-Dutra F, Mizurini DM, Monteiro RQ, Vazquez L, Bozza PT, Castro-Faria-Neto HC, Souza TML

J Mol Cell Biol, 14(6):mjac039, 01 Sep 2022

Cited by: 7 articles | PMID: 35759391 | PMCID: PMC9492308

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Fluorine Atoms on C₆H₅-Corrole Affect the Interaction with M^pro and PL^pro Proteases of SARS-CoV-2: Molecular Docking and 2D-QSAR Approaches.

Chaves OA, Rodrigues-Santos CE, Echevarria Á, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, Castro-Faria-Neto HC, Souza TMLE

Int J Mol Sci, 23(18):10936, 19 Sep 2022

Cited by: 1 article | PMID: 36142848 | PMCID: PMC9505658

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Computational and Experimental Approaches Identify Beta-Blockers as Potential SARS-CoV-2 Spike Inhibitors.

Puhl AC, Mottin M, Sacramento CQ, Tavella TA, Dias GG, Fintelman-Rodrigues N, Temerozo JR, Dias SSG, Ramos PRPDS, Merten EM, Pearce KH, Costa FTM, Premkumar L, Souza TML, Andrade CH, Ekins S

ACS Omega, 7(32):27950-27958, 08 Aug 2022

Cited by: 5 articles | PMID: 35983371 | PMCID: PMC9380819

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Commercially Available Flavonols Are Better SARS-CoV-2 Inhibitors than Isoflavone and Flavones.

Chaves OA, Fintelman-Rodrigues N, Wang X, Sacramento CQ, Temerozo JR, Ferreira AC, Mattos M, Pereira-Dutra F, Bozza PT, Castro-Faria-Neto HC, Russo JJ, Ju J, Souza TML

Viruses, 14(7):1458, 30 Jun 2022

Cited by: 16 articles | PMID: 35891437 | PMCID: PMC9324382

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Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology.

Temerozo JR, Fintelman-Rodrigues N, Dos Santos MC, Hottz ED, Sacramento CQ, de Paula Dias da Silva A, Mandacaru SC, Dos Santos Moraes EC, Trugilho MRO, Gesto JSM, Ferreira MA, Saraiva FB, Palhinha L, Martins-Gonçalves R, Azevedo-Quintanilha IG, Abrantes JL, Righy C, Kurtz P, Jiang H, [...] Souza TML

Microbiome, 10(1):65, 22 Apr 2022

Cited by: 24 articles | PMID: 35459226 | PMCID: PMC9024070

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VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells.

Temerozo JR, Sacramento CQ, Fintelman-Rodrigues N, Pão CRR, de Freitas CS, Dias SSG, Ferreira AC, Mattos M, Soares VC, Teixeira L, Azevedo-Quintanilha IG, Hottz ED, Kurtz P, Bozza FA, Bozza PT, Souza TML, Bou-Habib DC

J Leukoc Biol, 111(5):1107-1121, 24 Mar 2022

Cited by: 12 articles | PMID: 35322471 | PMCID: PMC9088587

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Macrophages undergo necroptosis during severe influenza A infection and contribute to virus-associated cytokine storm

Ferreira AC, Sacramento CQ, Pereira-Dutra FS, Fintelman-Rodrigues N, Silva PP, Mattos M, de Freitas CS, Marttorelli A, de Melo GR, Macedo MC, Azevedo-Quintanilha IG, Carlos AS, Emídio JV, Garcia CC, Bozza PT, Bozza FA, Souza TML

bioRxiv, 20 Apr 2022

Cited by: 0 articles | PPR: PPR493805

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Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts.

Teixeira L, Temerozo JR, Pereira-Dutra FS, Ferreira AC, Mattos M, Gonçalves BS, Sacramento CQ, Palhinha L, Cunha-Fernandes T, Dias SSG, Soares VC, Barreto EA, Cesar-Silva D, Fintelman-Rodrigues N, Pão CRR, de Freitas CS, Reis PA, Hottz ED, Bozza FA, [...] Bozza PT

Front Immunol, 13:820131, 18 Feb 2022

Cited by: 24 articles | PMID: 35251001 | PMCID: PMC8895251

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Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture.

Wang X, Sacramento CQ, Jockusch S, Chaves OA, Tao C, Fintelman-Rodrigues N, Chien M, Temerozo JR, Li X, Kumar S, Xie W, Patel DJ, Meyer C, Garzia A, Tuschl T, Bozza PT, Russo JJ, Souza TML, Ju J

Commun Biol, 5(1):154, 22 Feb 2022

Cited by: 35 articles | PMID: 35194144 | PMCID: PMC8863796

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Bioassay-Guided Fractionation of Siparuna glycycarpa n-Butanol Extract with Inhibitory Activity against Influenza A(H1N1)pdm09 Virus by Centrifugal Partition Chromatography (CPC).

Leal CM, Leitão SG, de Mello LLO, Rangel IC, da Silva CVA, Miranda MD, Tucci AR, de Assis CB, Sacramento CQ, Fintelman-Rodrigues N, Koolen HHF, Vaz BG, Simas RC, Leitão GG

Molecules, 27(2):399, 08 Jan 2022

Cited by: 1 article | PMID: 35056716 | PMCID: PMC8781433

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Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells.

Sacramento CQ, Fintelman-Rodrigues N, Dias SSG, Temerozo JR, Da Silva APD, da Silva CS, Blanco C, Ferreira AC, Mattos M, Soares VC, Pereira-Dutra F, Miranda MD, Barreto-Vieira DF, da Silva MAN, Santos SS, Torres M, Chaves OA, Rajoli RKR, Paccanaro A, [...] Souza TML

Viruses, 14(2):374, 11 Feb 2022

Cited by: 10 articles | PMID: 35215969 | PMCID: PMC8874959

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Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 M^pro, Impairing Variants Replication In Vitro and In Vivo.

Chaves OA, Sacramento CQ, Ferreira AC, Mattos M, Fintelman-Rodrigues N, Temerozo JR, Vazquez L, Pinto DP, da Silveira GPE, da Fonseca LB, Pereira HM, Carlos AS, d'Avila JC, Viola JPB, Monteiro RQ, Bozza PT, Castro-Faria-Neto HC, Souza TML

Pharmaceuticals (Basel), 15(1):21, 24 Dec 2021

Cited by: 16 articles | PMID: 35056078 | PMCID: PMC8777605

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Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating.

Salerno JA, Torquato T, Temerozo JR, Goto-Silva L, Karmirian K, Mendes MA, Sacramento CQ, Fintelman-Rodrigues N, Souza LRQ, Ornelas IM, Veríssimo CP, Aragão LGHS, Vitória G, Pedrosa CSG, da Silva Gomes Dias S, Cardoso Soares V, Puig-Pijuan T, Salazar V, Dariolli R, [...] Rehen SK

PeerJ, 9:e12595, 20 Dec 2021

Cited by: 5 articles | PMID: 35036128 | PMCID: PMC8697769

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Atazanavir is a competitive inhibitor of SARS-CoV-2 M^pro, impairing variants replication in vitro and in vivo

Chaves OA, Sacramento CQ, C. Ferreira A, Mattos M, Fintelman-Rodrigues N, Temerozo JR, Pinto DP, da Silveira GPE, da Fonseca LB, Pereira HM, Carlos AS, Pinto d’Ávila JdC, Viola JP, Monteiro RQ, Vazquez L, Bozza PT, Castro-Faria-Neto HC, Souza TML

bioRxiv, 24 Nov 2021

Cited by: 0 articles | PPR: PPR425063

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Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication by targeting its major protease in a non-competitive way

Augusto Chaves O, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, Pereira-Dutra F, Mizurini DM, Monteiro RQ, Vazquez L, Bozza PT, Castro-Faria-Neto HC, Souza TML

bioRxiv, 24 Sep 2021

Cited by: 0 articles | PPR: PPR398883

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Anti-PF4 positivity and platelet activation after Ad26.COV2·S vaccination in Brazil.

Extracellular vesicles from primary human macrophages stimulated with VIP or PACAP mediate anti-SARS-CoV-2 activities in monocytes through NF-κB signaling pathway.

Unveiling the Antiviral Capabilities of Targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2.

Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2

Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.

Severe influenza infection is associated with inflammatory programmed cell death in infected macrophages.

Dengue induces iNOS expression and nitric oxide synthesis in platelets through IL-1R.

Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation.

Agathisflavone, a natural biflavonoid that inhibits SARS-CoV-2 replication by targeting its proteases.

Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19.

Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication and its major protease in a non-competitive way.

Fluorine Atoms on C₆H₅-Corrole Affect the Interaction with M^pro and PL^pro Proteases of SARS-CoV-2: Molecular Docking and 2D-QSAR Approaches.

Computational and Experimental Approaches Identify Beta-Blockers as Potential SARS-CoV-2 Spike Inhibitors.

Commercially Available Flavonols Are Better SARS-CoV-2 Inhibitors than Isoflavone and Flavones.

Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology.

VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells.

Macrophages undergo necroptosis during severe influenza A infection and contribute to virus-associated cytokine storm

Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts.

Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture.

Bioassay-Guided Fractionation of Siparuna glycycarpa n-Butanol Extract with Inhibitory Activity against Influenza A(H1N1)pdm09 Virus by Centrifugal Partition Chromatography (CPC).

Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells.

Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 M^pro, Impairing Variants Replication In Vitro and In Vivo.

Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating.

Atazanavir is a competitive inhibitor of SARS-CoV-2 M^pro, impairing variants replication in vitro and in vivo

Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication by targeting its major protease in a non-competitive way

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