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Search life-sciences literature (45,103,589 articles, preprints and more)

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Target occupancy study and whole-body dosimetry with a MAGL PET ligand [¹¹C]PF-06809247 in non-human primates.
Arakawa R, Takano A, Nag S, Jia Z, Amini N, Maresca KP, Zhang L, Keliher EJ, Butler CR, Piro JR, Samad TA, Smith D, Nason D, O'Neil S, Trapa P, Fonseca KR, Litchfield J, McCarthy T, Carson RE, Halldin C
EJNMMI Res, 12(1):13, 04 Mar 2022
Cited by: 1 article | PMID: 35244788 | PMCID: PMC8897535
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Target Occupancy Study and Whole-Body Dosimetry with a MAGL PET Ligand 11C-PF-06809247 in non-human Primates
Arakawa R, Takano A, Nag S, Jia Z, Amini N, Maresca KP, Zhang L, Keliher EJ, Butler CR, Piro JR, Samad TA, Smith D, Nason D, O’Neil S, Trapa P, Fonseca KR, Litchfield J, McCarthy T, Carson RE, Halldin C
Research Square, 21 Sep 2021
Cited by: 0 articles | PPR: PPR397482
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Sustained reduction of serum neurofilament light chain over 7 years by alemtuzumab in early relapsing-remitting MS.
Kuhle J, Daizadeh N, Benkert P, Maceski A, Barro C, Michalak Z, Sormani MP, Godin J, Shankara S, Samad TA, Jacobs A, Chung L, Rӧsch N, Kaiser C, Mitchell CP, Leppert D, Havari E, Kappos L
Mult Scler, 28(4):573-582, 11 Aug 2021
Cited by: 16 articles | PMID: 34378446 | PMCID: PMC8958562
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Tumor Microenvironment in Prostate Cancer: Toward Identification of Novel Molecular Biomarkers for Diagnosis, Prognosis, and Therapy Development.
Bahmad HF, Jalloul M, Azar J, Moubarak MM, Samad TA, Mukherji D, Al-Sayegh M, Abou-Kheir W
Front Genet, 12:652747, 26 Mar 2021
Cited by: 36 articles | PMID: 33841508 | PMCID: PMC8033163
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Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer's disease.
Whelan CD, Mattsson N, Nagle MW, Vijayaraghavan S, Hyde C, Janelidze S, Stomrud E, Lee J, Fitz L, Samad TA, Ramaswamy G, Margolin RA, Malarstig A, Hansson O
Acta Neuropathol Commun, 7(1):169, 06 Nov 2019
Cited by: 124 articles | PMID: 31694701 | PMCID: PMC6836495
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Free Water in White Matter Differentiates MCI and AD From Control Subjects.
Dumont M, Roy M, Jodoin PM, Morency FC, Houde JC, Xie Z, Bauer C, Samad TA, Van Dijk KRA, Goodman JA, Descoteaux M, Alzheimer's Disease Neuroimaging Initiative
Front Aging Neurosci, 11:270, 02 Oct 2019
Cited by: 51 articles | PMID: 31632265 | PMCID: PMC6783505
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Free water in white matter differentiates MCI and AD from control subjects
Dumont M, Roy M, Jodoin P, Morency FC, Houde J, Xie Z, Bauer C, Samad TA, Van Dijk KRA, Goodman JA, Descoteaux M
bioRxiv, 31 Jan 2019
Cited by: 0 articles | PPR: PPR68992
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Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury.
Piro JR, Suidan GL, Quan J, Pi Y, O'Neill SM, Ilardi M, Pozdnyakov N, Lanz TA, Xi H, Bell RD, Samad TA
J Neuroinflammation, 15(1):142, 14 May 2018
Cited by: 27 articles | PMID: 29759062 | PMCID: PMC5952841
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Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
McAllister LA, Butler CR, Mente S, O'Neil SV, Fonseca KR, Piro JR, Cianfrogna JA, Foley TL, Gilbert AM, Harris AR, Helal CJ, Johnson DS, Montgomery JI, Nason DM, Noell S, Pandit J, Rogers BN, Samad TA, Shaffer CL, [...] Brodney MA
J Med Chem, 61(7):3008-3026, 15 Mar 2018
Cited by: 23 articles | PMID: 29498843
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Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.
Butler CR, Beck EM, Harris A, Huang Z, McAllister LA, Am Ende CW, Fennell K, Foley TL, Fonseca K, Hawrylik SJ, Johnson DS, Knafels JD, Mente S, Noell GS, Pandit J, Phillips TB, Piro JR, Rogers BN, Samad TA, [...] Brodney MA
J Med Chem, 60(23):9860-9873, 05 Dec 2017
Cited by: 19 articles | PMID: 29148769
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Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.
Terrone G, Pauletti A, Salamone A, Rizzi M, Villa BR, Porcu L, Sheehan MJ, Guilmette E, Butler CR, Piro JR, Samad TA, Vezzani A
Epilepsia, 59(1):79-91, 24 Nov 2017
Cited by: 21 articles | PMID: 29171003
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Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity.
Bales KR, O'Neill SM, Pozdnyakov N, Pan F, Caouette D, Pi Y, Wood KM, Volfson D, Cirrito JR, Han BH, Johnson AW, Zipfel GJ, Samad TA
Brain, 139(pt 2):563-577, 22 Oct 2015
Cited by: 35 articles | PMID: 26493635
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A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease.
Piro JR, Benjamin DI, Duerr JM, Pi Y, Gonzales C, Wood KM, Schwartz JW, Nomura DK, Samad TA
Cell Rep, 1(6):617-623, 21 Jun 2012
Cited by: 121 articles | PMID: 22813736 | PMCID: PMC3715876
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The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling.
Ma CH, Brenner GJ, Omura T, Samad OA, Costigan M, Inquimbert P, Niederkofler V, Salie R, Sun CC, Lin HY, Arber S, Coppola G, Woolf CJ, Samad TA
J Neurosci, 31(50):18391-18400, 01 Dec 2011
Cited by: 47 articles | PMID: 22171041 | PMCID: PMC3243947
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Genome-wide association study identifies multiple novel loci associated with disease progression in subjects with mild cognitive impairment.
Hu X, Pickering EH, Hall SK, Naik S, Liu YC, Soares H, Katz E, Paciga SA, Liu W, Aisen PS, Bales KR, Samad TA, John SL
Transl Psychiatry, 1:e54, 15 Nov 2011
Cited by: 24 articles | PMID: 22833209 | PMCID: PMC3309471
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Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain.
von Schack D, Agostino MJ, Murray BS, Li Y, Reddy PS, Chen J, Choe SE, Strassle BW, Li C, Bates B, Zhang L, Hu H, Kotnis S, Bingham B, Liu W, Whiteside GT, Samad TA, Kennedy JD, Ajit SK
PLoS One, 6(3):e17670, 14 Mar 2011
Cited by: 88 articles | PMID: 21423802 | PMCID: PMC3056716
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Depression-like phenotype following chronic CB1 receptor antagonism.
Beyer CE, Dwyer JM, Piesla MJ, Platt BJ, Shen R, Rahman Z, Chan K, Manners MT, Samad TA, Kennedy JD, Bingham B, Whiteside GT
Neurobiol Dis, 39(2):148-155, 08 Apr 2010
Cited by: 86 articles | PMID: 20381618
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Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.
Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY
J Immunol, 186(3):1369-1376, 27 Dec 2010
Cited by: 42 articles | PMID: 21187450 | PMCID: PMC3670585
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TRPV1 signaling: mechanistic understanding and therapeutic potential.
Xia R, Samad TA, Btesh J, Jiang LH, Kays I, Stjernborg L, Dekker N
Curr Top Med Chem, 11(17):2180-2191, 01 Jan 2011
Cited by: 15 articles | PMID: 21671876
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The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid.
Nickerson-Nutter CL, Goodwin D, Shen MW, Damphousse C, Duan W, Samad TA, McKew JC, Lee KL, Zaleska MM, Mollova N, Clark JD
Neuropharmacology, 60(4):633-641, 10 Dec 2010
Cited by: 2 articles | PMID: 21146550
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Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system.
Chanda PK, Gao Y, Mark L, Btesh J, Strassle BW, Lu P, Piesla MJ, Zhang MY, Bingham B, Uveges A, Kowal D, Garbe D, Kouranova EV, Ring RH, Bates B, Pangalos MN, Kennedy JD, Whiteside GT, Samad TA
Mol Pharmacol, 78(6):996-1003, 20 Sep 2010
Cited by: 147 articles | PMID: 20855465
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Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform.
Kotnis S, Bingham B, Vasilyev DV, Miller SW, Bai Y, Yeola S, Chanda PK, Bowlby MR, Kaftan EJ, Samad TA, Whiteside GT
Mol Pharmacol, 77(6):953-960, 11 Mar 2010
Cited by: 18 articles | PMID: 20223879
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Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice.
Gao Y, Vasilyev DV, Goncalves MB, Howell FV, Hobbs C, Reisenberg M, Shen R, Zhang MY, Strassle BW, Lu P, Mark L, Piesla MJ, Deng K, Kouranova EV, Ring RH, Whiteside GT, Bates B, Walsh FS, Williams G, [...] Doherty P
J Neurosci, 30(6):2017-2024, 01 Feb 2010
Cited by: 293 articles | PMID: 20147530 | PMCID: PMC6634037
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Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells.
Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY
J Am Soc Nephrol, 21(4):666-677, 18 Feb 2010
Cited by: 28 articles | PMID: 20167703 | PMCID: PMC2844302
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Simultaneous determination of 2-arachidonoylglycerol, 1-arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry.
Zhang MY, Gao Y, Btesh J, Kagan N, Kerns E, Samad TA, Chanda PK
J Mass Spectrom, 45(2):167-177, 01 Feb 2010
Cited by: 18 articles | PMID: 19950120
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