Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

Search life-sciences literature (45,103,589 articles, preprints and more)

Search results

1-25 of 129 results

Sort by:

Relevance ^{Relevance: This is determined based on a ranking of criteria including term frequency, rarity of term, recency of article, whether there is a Title or Author field match, etc.}

Times cited

Date

1 2 3 Next ...

An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins.
Brennan A, Layfield R, Long J, Williams HEL, Oldham NJ, Scott D, Searle MS
J Biol Chem, 298(2):101514, 18 Dec 2021
Cited by: 4 articles | PMID: 34929165 | PMCID: PMC8762078
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
G-quadruplex ligands mediate downregulation of DUX4 expression.
Ciszewski L, Lu-Nguyen N, Slater A, Brennan A, Williams HEL, Dickson G, Searle MS, Popplewell L
Nucleic Acids Res, 48(8):4179-4194, 01 May 2020
Cited by: 16 articles | PMID: 32182342 | PMCID: PMC7192601
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib.
Morgan J, Saleem M, Ng R, Armstrong C, Wong SS, Caulton SG, Fickling A, Williams HEL, Munday AD, López JA, Searle MS, Emsley J
Blood Adv, 3(9):1450-1459, 01 May 2019
Cited by: 11 articles | PMID: 31053572 | PMCID: PMC6517656
Add to export list Free full text in Europe PMC
DNA replication initiation in Bacillus subtilis: structural and functional characterization of the essential DnaA-DnaD interaction.
Martin E, Williams HEL, Pitoulias M, Stevens D, Winterhalter C, Craggs TD, Murray H, Searle MS, Soultanas P
Nucleic Acids Res, 47(4):2101-2112, 01 Feb 2019
Cited by: 6 articles | PMID: 30534966 | PMCID: PMC6393240
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
DNA replication initiation in Bacillus subtilis; Structural and functional characterisation of the essential DnaA-DnaD interaction
Martin E, Williams HEL, Pitoulias M, Stevens D, Winterhalter C, Craggs TD, Murray H, Searle MS, Soultanas P
bioRxiv, 16 Oct 2018
Cited by: 0 articles | PPR: PPR59047
Add to export list Preprint
ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.
Goode A, Rea S, Sultana M, Shaw B, Searle MS, Layfield R
Mol Cell Neurosci, 76:52-58, 20 Aug 2016
Cited by: 26 articles | PMID: 27554286 | PMCID: PMC5062946
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Enantiopure titanocene complexes--direct evidence for paraptosis in cancer cells.
Cini M, Williams H, Fay MW, Searle MS, Woodward S, Bradshaw TD
Metallomics, 8(3):286-297, 01 Mar 2016
Cited by: 9 articles | PMID: 26806372
Add to export list
Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin.
Scott D, Garner TP, Long J, Strachan J, Mistry SC, Bottrill AR, Tooth DJ, Searle MS, Oldham NJ, Layfield R
Proteomics, 16(14):1961-1969, 01 Jul 2016
Cited by: 8 articles | PMID: 27037516
Add to export list
Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.
Goode A, Butler K, Long J, Cavey J, Scott D, Shaw B, Sollenberger J, Gell C, Johansen T, Oldham NJ, Searle MS, Layfield R
Autophagy, 12(7):1094-1104, 09 May 2016
Cited by: 86 articles | PMID: 27158844 | PMCID: PMC4990988
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
SilE is an intrinsically disordered periplasmic "molecular sponge" involved in bacterial silver resistance.
Asiani KR, Williams H, Bird L, Jenner M, Searle MS, Hobman JL, Scott DJ, Soultanas P
Mol Microbiol, 101(5):731-742, 07 May 2016
Cited by: 21 articles | PMID: 27085056 | PMCID: PMC5008109
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Correction: Enantiopure titanocene complexes--direct evidence for paraptosis in cancer cells.
Cini M, Williams H, Fay MW, Searle MS, Woodward S, Bradshaw TD
Metallomics, 8(2):260, 01 Feb 2016
Cited by: 0 articles | PMID: 26847676
Add to export list
Method for the Purification of Endogenous Unanchored Polyubiquitin Chains.
Scott D, Strachan J, Krishna VG, Shaw B, Tooth DJ, Searle MS, Oldham NJ, Layfield R
Methods Mol Biol, 1449:203-213, 01 Jan 2016
Cited by: 2 articles | PMID: 27613037
Add to export list
Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences.
Cousins AR, Ritson D, Sharma P, Stevens MF, Moses JE, Searle MS
Chem Commun (Camb), 50(96):15202-15205, 01 Dec 2014
Cited by: 11 articles | PMID: 25338751
Add to export list
Ubiquitin-binding domains: mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes.
Scott D, Oldham NJ, Strachan J, Searle MS, Layfield R
Proteomics, 15(5-6):844-861, 28 Dec 2014
Cited by: 26 articles | PMID: 25327553
Add to export list Review
A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions.
Smith LD, Dickinson RL, Lucas CM, Cousins A, Malygin AA, Weldon C, Perrett AJ, Bottrill AR, Searle MS, Burley GA, Eperon IC
Cell Rep, 9(1):193-205, 25 Sep 2014
Cited by: 12 articles | PMID: 25263560 | PMCID: PMC4536295
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD.
Rea SL, Majcher V, Searle MS, Layfield R
Exp Cell Res, 325(1):27-37, 30 Jan 2014
Cited by: 87 articles | PMID: 24486447
Add to export list Review
A sequence-based approach for prediction of CsrA/RsmA targets in bacteria with experimental validation in Pseudomonas aeruginosa.
Kulkarni PR, Jia T, Kuehne SA, Kerkering TM, Morris ER, Searle MS, Heeb S, Rao J, Kulkarni RV
Nucleic Acids Res, 42(11):6811-6825, 29 Apr 2014
Cited by: 40 articles | PMID: 24782516 | PMCID: PMC4066749
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3.
Portman KL, Long J, Carr S, Briand L, Winzor DJ, Searle MS, Scott DJ
Biochemistry, 53(14):2371-2379, 07 Apr 2014
Cited by: 10 articles | PMID: 24665925
Add to export list
Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function.
Goode A, Long JE, Shaw B, Ralston SH, Visconti MR, Gianfrancesco F, Esposito T, Gennari L, Merlotti D, Rendina D, Rea SL, Sultana M, Searle MS, Layfield R
Biochim Biophys Acta, 1842(7):992-1000, 16 Mar 2014
Cited by: 18 articles | PMID: 24642144 | PMCID: PMC4034160
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.
Iachettini S, Stevens MF, Frigerio M, Hummersone MG, Hutchinson I, Garner TP, Searle MS, Wilson DW, Munde M, Nanjunda R, D'Angelo C, Zizza P, Rizzo A, Cingolani C, De Cicco F, Porru M, D'Incalci M, Leonetti C, Biroccio A, Salvati E
J Exp Clin Cancer Res, 32:68, 19 Sep 2013
Cited by: 11 articles | PMID: 24330541 | PMCID: PMC3849007
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Structural rearrangement in an RsmA/CsrA ortholog of Pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN.
Morris ER, Hall G, Li C, Heeb S, Kulkarni RV, Lovelock L, Silistre H, Messina M, Cámara M, Emsley J, Williams P, Searle MS
Structure, 21(9):1659-1671, 15 Aug 2013
Cited by: 50 articles | PMID: 23954502 | PMCID: PMC3791407
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1.
Edwards JM, Long J, de Moor CH, Emsley J, Searle MS
Nucleic Acids Res, 41(14):7153-7166, 06 Jun 2013
Cited by: 22 articles | PMID: 23748565 | PMCID: PMC3737555
Add to export list
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.
Wright T, Rea SL, Goode A, Bennett AJ, Ratajczak T, Long JE, Searle MS, Goldring CE, Park BK, Copple IM, Layfield R
Bone, 52(2):699-706, 29 Oct 2012
Cited by: 15 articles | PMID: 23117207
Add to export list
Overview of protein folding mechanisms: experimental and theoretical approaches to probing energy landscapes.
Morris ER, Searle MS
Curr Protoc Protein Sci, Chapter 28:28.2.1-28.2.22, 01 Apr 2012
Cited by: 6 articles | PMID: 22470128
Add to export list Review
Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains.
Searle MS, Garner TP, Strachan J, Long J, Adlington J, Cavey JR, Shaw B, Layfield R
Biochem Soc Trans, 40(2):404-408, 01 Apr 2012
Cited by: 14 articles | PMID: 22435820
Add to export list Review

1-25 of 129 results

1 2 3 Next ...

Search life-sciences literature (45,103,589 articles, preprints and more)

Search results

An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins.

G-quadruplex ligands mediate downregulation of DUX4 expression.

Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib.

DNA replication initiation in Bacillus subtilis: structural and functional characterization of the essential DnaA-DnaD interaction.

DNA replication initiation in Bacillus subtilis; Structural and functional characterisation of the essential DnaA-DnaD interaction

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling.

Enantiopure titanocene complexes--direct evidence for paraptosis in cancer cells.

Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin.

Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.

SilE is an intrinsically disordered periplasmic "molecular sponge" involved in bacterial silver resistance.

Correction: Enantiopure titanocene complexes--direct evidence for paraptosis in cancer cells.

Method for the Purification of Endogenous Unanchored Polyubiquitin Chains.

Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences.

Ubiquitin-binding domains: mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes.

A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions.

SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD.

A sequence-based approach for prediction of CsrA/RsmA targets in bacteria with experimental validation in Pseudomonas aeruginosa.

Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3.

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function.

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.

Structural rearrangement in an RsmA/CsrA ortholog of Pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN.

Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1.

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.

Overview of protein folding mechanisms: experimental and theoretical approaches to probing energy landscapes.

Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains.

Partnerships & funding