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Search life-sciences literature (45,103,589 articles, preprints and more)

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Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.
Henderson SH, Sorrell FJ, Bennett JM, Fedorov O, Hanley MT, Godoi PH, Ruela de Sousa R, Robinson S, Navratilova IH, Elkins JM, Ward SE
Eur J Med Chem, 269:116292, 07 Mar 2024
Cited by: 1 article | PMID: 38479168
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Engineering CRBN for rapid identification of next generation binders
Bailey HJ, Eisert J, Vollrath J, Leibrock E, Kondratov I, Matviyuk T, Tolmachova N, Langer JD, Wegener AA, Sorrell FJ, Dikic I
bioRxiv, 20 Jan 2024
Cited by: 0 articles | PPR: PPR790290
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Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Krieger J, Sorrell FJ, Wegener AA, Leuthner B, Machrouhi-Porcher F, Hecht M, Leibrock EM, Müller JE, Eisert J, Hartung IV, Schlesiger S
ChemMedChem, 18(8):e202200615, 28 Feb 2023
Cited by: 9 articles | PMID: 36749883
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Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.
Chen Z, Zhang J, Murillo-de-Ozores AR, Castañeda-Bueno M, D'Amico F, Heilig R, Manning CE, Sorrell FJ, D'Angiolella V, Fischer R, Mulder MPC, Gamba G, Alessi DR, Bullock AN
Biochem J, 479(5):661-675, 01 Mar 2022
Cited by: 3 articles | PMID: 35179207 | PMCID: PMC9022995
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
Serafim RAM, Sorrell FJ, Berger BT, Collins RJ, Vasconcelos SNS, Massirer KB, Knapp S, Bennett J, Fedorov O, Patel H, Zuercher WJ, Elkins JM
J Med Chem, 64(18):13259-13278, 31 Aug 2021
Cited by: 3 articles | PMID: 34463505
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Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase
Chen Z, Zhang J, Heilig R, Sorrell FJ, D’Angiolella V, Fischer R, Alessi DR, Bullock AN
bioRxiv, 29 Jun 2020
Cited by: 0 articles | PPR: PPR181578
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Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini GP, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaya V, Morgan J, [...] Butterworth S
J Med Chem, 63(13):6784-6801, 22 Jun 2020
Cited by: 10 articles | PMID: 32433887 | PMCID: PMC7445743
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STK32A is a dual-specificity AGC kinase with a preference for acidic substrates
Sorrell FJ, Miranda F, Abdul Azeez KR, Chaikuad A, Kettenbach AN, Gerber SA, Knapp S, Ahmed AA, Elkins JM
bioRxiv, 05 Mar 2020
Cited by: 0 articles | PPR: PPR116293
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Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.
Verdonck S, Pu SY, Sorrell FJ, Elkins JM, Froeyen M, Gao LJ, Prugar LI, Dorosky DE, Brannan JM, Barouch-Bentov R, Knapp S, Dye JM, Herdewijn P, Einav S, De Jonghe S
J Med Chem, 62(12):5810-5831, 12 Jun 2019
Cited by: 20 articles | PMID: 31136173 | PMCID: PMC6825517
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Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.
Sorrell FJ, Kilian LM, Elkins JM
Biochem J, 476(7):1037-1051, 04 Apr 2019
Cited by: 9 articles | PMID: 30858169 | PMCID: PMC6448136
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WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.
Agajanian MJ, Walker MP, Axtman AD, Ruela-de-Sousa RR, Serafin DS, Rabinowitz AD, Graham DM, Ryan MB, Tamir T, Nakamichi Y, Gammons MV, Bennett JM, Couñago RM, Drewry DH, Elkins JM, Gileadi C, Gileadi O, Godoi PH, Kapadia N, [...] Major MB
Cell Rep, 26(1):79-93.e8, 01 Jan 2019
Cited by: 35 articles | PMID: 30605688 | PMCID: PMC6315376
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AAK1 inhibits WNT signaling by promoting clathrin-mediated endocytosis of LRP6
Agajanian MJ, Walker MP, Axtman AD, Ruela-de-Sousa RR, Rabinowitz AD, Graham DM, Ryan M, Serafin DS, Bennett JM, Couñago RM, Drewry DH, Elkins JM, Gileadi C, Gileadi O, Godoi PH, Kapadia N, Müller S, Santiago AS, Sorrell FJ, [...] Major MB
bioRxiv, 01 Feb 2018
Cited by: 0 articles | PPR: PPR18862
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Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Pinkas DM, Sanvitale CE, Bufton JC, Sorrell FJ, Solcan N, Chalk R, Doutch J, Bullock AN
Biochem J, 474(22):3747-3761, 01 Nov 2017
Cited by: 49 articles | PMID: 28963344 | PMCID: PMC5664961
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Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
Sorrell FJ, Szklarz M, Abdul Azeez KR, Elkins JM, Knapp S
Structure, 24(3):401-411, 04 Feb 2016
Cited by: 84 articles | PMID: 26853940 | PMCID: PMC4780864
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Structural basis of Keap1 interactions with Nrf2.
Canning P, Sorrell FJ, Bullock AN
Free Radic Biol Med, 88(pt b):101-107, 07 Jun 2015
Cited by: 259 articles | PMID: 26057936 | PMCID: PMC4668279
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.
Wilbek TS, Skovgaard T, Sorrell FJ, Knapp S, Berthelsen J, Strømgaard K
Chembiochem, 16(1):59-63, 07 Nov 2014
Cited by: 10 articles | PMID: 25382253 | PMCID: PMC4431585
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Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.
Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T
Biochem J, 460(2):237-246, 01 Jun 2014
Cited by: 45 articles | PMID: 24641320 | PMCID: PMC4019986
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Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity.
Thompson MJ, Louth JC, Ferrara S, Jackson MP, Sorrell FJ, Cochrane EJ, Gever J, Baxendale S, Silber BM, Roehl HH, Chen B
Eur J Med Chem, 46(9):4125-4132, 17 Jun 2011
Cited by: 14 articles | PMID: 21726921
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Improved 2,4-diarylthiazole-based antiprion agents: switching the sense of the amide group at C5 leads to an increase in potency.
Thompson MJ, Louth JC, Greenwood GK, Sorrell FJ, Knight SG, Adams NB, Chen B
ChemMedChem, 5(9):1476-1488, 01 Sep 2010
Cited by: 6 articles | PMID: 20635376
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Development of a differential scanning fluorimetry based high throughput screening assay for the discovery of affinity binders against an anthrax protein.
Sorrell FJ, Greenwood GK, Birchall K, Chen B
J Pharm Biomed Anal, 52(5):802-808, 01 Sep 2010
Cited by: 13 articles | PMID: 20376913
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Structure-activity relationship refinement and further assessment of indole-3-glyoxylamides as a lead series against prion disease.
Thompson MJ, Louth JC, Ferrara S, Sorrell FJ, Irving BJ, Cochrane EJ, Meijer AJ, Chen B
ChemMedChem, 6(1):115-130, 01 Jan 2011
Cited by: 10 articles | PMID: 21154498
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1-21 of 21 results

Search life-sciences literature (45,103,589 articles, preprints and more)

Search results

Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.

Engineering CRBN for rapid identification of next generation binders

Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.

STK32A is a dual-specificity AGC kinase with a preference for acidic substrates

Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.

Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.

AAK1 inhibits WNT signaling by promoting clathrin-mediated endocytosis of LRP6

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.

Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.

Structural basis of Keap1 interactions with Nrf2.

Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.

Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity.

Improved 2,4-diarylthiazole-based antiprion agents: switching the sense of the amide group at C5 leads to an increase in potency.

Development of a differential scanning fluorimetry based high throughput screening assay for the discovery of affinity binders against an anthrax protein.

Structure-activity relationship refinement and further assessment of indole-3-glyoxylamides as a lead series against prion disease.

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