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Cryo-EM structure of a novel α-synuclein filament subtype from multiple system atrophy.
Yan NL, Candido F, Tse E, Melo AA, Prusiner SB, Mordes DA, Southworth DR, Paras NA, Merz GE
FEBS Lett, 07 Nov 2024
Cited by: 0 articles | PMID: 39511911
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Amyloid accelerator polyphosphate fits as the mystery density in α-synuclein fibrils.
Huettemann P, Mahadevan P, Lempart J, Tse E, Dehury B, Edwards BFP, Southworth DR, Sahoo BR, Jakob U
PLoS Biol, 22(10):e3002650, 31 Oct 2024
Cited by: 0 articles | PMID: 39480879 | PMCID: PMC11527176
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Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP.
Nadel CM, Pokhrel S, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE
Nat Commun, 15(1):7972, 12 Sep 2024
Cited by: 0 articles | PMID: 39266525 | PMCID: PMC11393453
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Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly.
Braxton JR, Shao H, Tse E, Gestwicki JE, Southworth DR
Nat Struct Mol Biol, 01 Jul 2024
Cited by: 1 article | PMID: 38951622
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Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.
Ghosh U, Tse E, Yang H, Shi M, Caro CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C
Acta Neuropathol Commun, 12(1):94, 12 Jun 2024
Cited by: 0 articles | PMID: 38867338 | PMCID: PMC11167798
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Structure of a novel α-synuclein filament fold from multiple system atrophy
Yan NL, Candido F, Tse E, Melo AA, Prusiner SB, Mordes DA, Southworth DR, Paras NA, Merz GE
bioRxiv, 04 Jul 2024
Cited by: 0 articles | PPR: PPR877153
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Design principles to tailor Hsp104 therapeutics
Lin J, Carman PJ, Gambogi CW, Kendsersky NM, Chuang E, Gates SN, Yokom AL, Rizo AN, Southworth DR, Shorter J
bioRxiv, 28 Apr 2024
Cited by: 0 articles | PPR: PPR844933
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Amyloid Accelerator Polyphosphate Implicated as the Mystery Density in α-Synuclein Fibrils
Huettemann P, Mahadevan P, Lempart J, Tse E, Dehury B, Edwards BFP, Southworth DR, Sahoo BR, Jakob U
bioRxiv, 02 May 2024
Cited by: 0 articles | PPR: PPR846569
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Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold
Ghosh U, Tse E, Yang H, Shi M, Caro CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C
bioRxiv, 03 Apr 2024
Cited by: 0 articles | PPR: PPR833780
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The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR
Nat Struct Mol Biol, 30(12):2009-2019, 09 Nov 2023
Cited by: 7 articles | PMID: 37945741 | PMCID: PMC10716044
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Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry.
Felker D, Lee K, Pospiech TH, Morishima Y, Zhang H, Lau M, Southworth DR, Osawa Y
J Biol Chem, 300(1):105464, 16 Nov 2023
Cited by: 1 article | PMID: 37979917 | PMCID: PMC10716779
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Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP
Nadel CM, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE
bioRxiv, 16 Aug 2023
Cited by: 0 articles | PPR: PPR705877
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Structural insights of the p97/VCP AAA+ ATPase: How adapter interactions coordinate diverse cellular functionality.
Braxton JR, Southworth DR
J Biol Chem, 299(11):105182, 22 Aug 2023
Cited by: 8 articles | PMID: 37611827 | PMCID: PMC10641518
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The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT).
Nadel CM, Thwin AC, Callahan M, Lee K, Connelly E, Craik CS, Southworth DR, Gestwicki JE
J Mol Biol, 435(11):168026, 16 Jun 2023
Cited by: 4 articles | PMID: 37330289 | PMCID: PMC10491737
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The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions
Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR
bioRxiv, 15 May 2023
Cited by: 0 articles | PPR: PPR660668
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Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly
Braxton JR, Shao H, Tse E, Gestwicki JE, Southworth DR
bioRxiv, 15 May 2023
Cited by: 0 articles | PPR: PPR660675
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CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Parra Bravo C, Bose R, Travaglini KJ, Lam VL, Goodness D, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan H, Carroll EC, Lawrence RE, Gestwicki JE, [...] Kampmann M
bioRxiv, 17 Jun 2023
Cited by: 0 articles | PPR: PPR677535
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Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments.
Merz GE, Chalkley MJ, Tan SK, Tse E, Lee J, Prusiner SB, Paras NA, DeGrado WF, Southworth DR
Nat Commun, 14(1):3048, 26 May 2023
Cited by: 18 articles | PMID: 37236970 | PMCID: PMC10220082
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Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States.
Montgomery KM, Carroll EC, Thwin AC, Quddus AY, Hodges P, Southworth DR, Gestwicki JE
J Am Chem Soc, 08 Feb 2023
Cited by: 9 articles | PMID: 36753572 | PMCID: PMC9951223
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Stacked binding of a small molecule PET tracer to Alzheimer’s tau paired helical filaments
Merz GE, Chalkley MJ, Tan S, Tse E, Lee J, Prusiner SB, Paras NA, DeGrado WF, Southworth DR
bioRxiv, 03 Oct 2022
Cited by: 0 articles | PPR: PPR553425
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The Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States
Montgomery KM, Carroll EC, Thwin A, Hodges P, Southworth DR, Gestwicki JE
bioRxiv, 28 Jul 2022
Cited by: 0 articles | PPR: PPR524732
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Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3.
Cupo RR, Rizo AN, Braun GA, Tse E, Chuang E, Gupta K, Southworth DR, Shorter J
Cell Rep, 40(13):111408, 01 Sep 2022
Cited by: 8 articles | PMID: 36170828 | PMCID: PMC9584538
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Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3
Cupo RR, Rizo AN, Braun GA, Tse E, Chuang E, Southworth DR, Shorter J
bioRxiv, 17 Feb 2022
Cited by: 0 articles | PPR: PPR455859
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The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.
Lee K, Thwin AC, Nadel CM, Tse E, Gates SN, Gestwicki JE, Southworth DR
Mol Cell, 81(17):3496-3508.e5, 10 Aug 2021
Cited by: 29 articles | PMID: 34380015 | PMCID: PMC8418782
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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes
Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, [...] Verba KA
bioRxiv, 12 May 2021
Cited by: 0 articles | PPR: PPR338658
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