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Search life-sciences literature (45,103,589 articles, preprints and more)

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The pyruvate dehydrogenase complex at the epigenetic crossroads of acetylation and lactylation.
Stacpoole PW, Dirain CO
Mol Genet Metab, 143(1-2):108540, 16 Jul 2024
Cited by: 0 articles | PMID: 39067348
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Clinical physiology and pharmacology of GSTZ1/MAAI.
Stacpoole PW
Biochem Pharmacol, 217:115818, 22 Sep 2023
Cited by: 1 article | PMID: 37742772
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The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat.
Stacpoole PW, McCall CE
Mitochondrion, 70:59-102, 01 Mar 2023
Cited by: 11 articles | PMID: 36863425
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In-vivo magnetic resonance spectroscopy of lactate as a non-invasive biomarker of dichloroacetate activity in cancer and non-cancer central nervous system disorders.
Kamson DO, Chinnasamy V, Grossman SA, Bettegowda C, Barker PB, Stacpoole PW, Oeltzschner G
Front Oncol, 13:1077461, 17 Mar 2023
Cited by: 4 articles | PMID: 37007074 | PMCID: PMC10063958
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Sepsis, pyruvate, and mitochondria energy supply chain shortage.
McCall CE, Zhu X, Zabalawi M, Long D, Quinn MA, Yoza BK, Stacpoole PW, Vachharajani V
J Leukoc Biol, 112(6):1509-1514, 22 Jul 2022
Cited by: 13 articles | PMID: 35866365 | PMCID: PMC9796618
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Dichloroacetate improves systemic energy balance and feeding behavior during sepsis.
Oh TS, Zabalawi M, Jain S, Long D, Stacpoole PW, McCall CE, Quinn MA
JCI Insight, 7(12):e153944, 22 Jun 2022
Cited by: 8 articles | PMID: 35730570 | PMCID: PMC9309051
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Sodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor.
Joseph S, Li M, Zhang S, Horne L, Stacpoole PW, Wohlgemuth SE, Edison AS, Wood C, Keller-Wood M
Am J Physiol Regul Integr Comp Physiol, 322(1):R83-R98, 01 Dec 2021
Cited by: 1 article | PMID: 34851727 | PMCID: PMC8791792
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Dichloroacetate improves systemic energy balance and feeding behavior during sepsis
Oh TS, Zabalwi M, Jain S, Long D, Stacpoole PW, McCall CE, Quinn MA
bioRxiv, 22 Jul 2021
Cited by: 0 articles | PPR: PPR373592
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Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction.
Mainali R, Zabalawi M, Long D, Buechler N, Quillen E, Key CC, Zhu X, Parks JS, Furdui C, Stacpoole PW, Martinez J, McCall CE, Quinn MA
Elife, 10:e64611, 22 Feb 2021
Cited by: 25 articles | PMID: 33616039 | PMCID: PMC7901874
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Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1.
Squirewell EJ, Mareus R, Horne LP, Stacpoole PW, James MO
Drug Metab Dispos, 48(11):1224-1230, 01 Sep 2020
Cited by: 0 articles | PMID: 32873592 | PMCID: PMC7589945
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Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.
Squirewell EJ, Smeltz MG, Rowland-Faux L, Horne LP, Stacpoole PW, James MO
Drug Metab Dispos, 48(11):1217-1223, 01 Sep 2020
Cited by: 2 articles | PMID: 32873593 | PMCID: PMC7589944
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Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction
Mainali R, Zabalawi M, Long D, Buechler N, Quillen E, Key C, Zhu X, Parks JS, Furdui C, Stacpoole PW, Martinez J, McCall CE, Quinn MA
bioRxiv, 11 Jun 2020
Cited by: 0 articles | PPR: PPR174284
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Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses.
Joseph S, Sharma A, Horne LP, Wood CE, Langaee T, James MO, Stacpoole PW, Keller-Wood M
Drug Metab Dispos, 49(6):451-458, 01 Jun 2020
Cited by: 1 article | PMID: 33811107 | PMCID: PMC11019763
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Mitochondrial diseases in North America: An analysis of the NAMDC Registry.
Barca E, Long Y, Cooley V, Schoenaker R, Emmanuele V, DiMauro S, Cohen BH, Karaa A, Vladutiu GD, Haas R, Van Hove JLK, Scaglia F, Parikh S, Bedoyan JK, DeBrosse SD, Gavrilova RH, Saneto RP, Enns GM, Stacpoole PW, [...] Hirano M
Neurol Genet, 6(2):e402, 02 Mar 2020
Cited by: 32 articles | PMID: 32337332 | PMCID: PMC7164977
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Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.
Jahn SC, Gay LA, Weaver CJ, Renne R, Langaee TY, Stacpoole PW, James MO
Drug Metab Dispos, 48(7):563-569, 01 May 2020
Cited by: 3 articles | PMID: 32357971 | PMCID: PMC7289049
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Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes.
Zhu X, Long D, Zabalawi M, Ingram B, Yoza BK, Stacpoole PW, McCall CE
J Leukoc Biol, 107(3):467-484, 02 Jan 2020
Cited by: 18 articles | PMID: 31894617 | PMCID: PMC7044062
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Mitochondrial Glutathione Transferase Zeta 1 Is Inactivated More Rapidly by Dichloroacetate than the Cytosolic Enzyme in Adult and Juvenile Rat Liver.
Smeltz MG, Hu Z, Zhong G, Jahn SC, Rowland-Faux L, Horne LP, Stacpoole PW, James MO
Chem Res Toxicol, 32(10):2042-2052, 01 Oct 2019
Cited by: 4 articles | PMID: 31524376 | PMCID: PMC8582596
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The changing landscape of clinical trials for mitochondrial diseases: 2011 to present.
Khayat D, Kurtz TL, Stacpoole PW
Mitochondrion, 50:51-57, 25 Oct 2019
Cited by: 3 articles | PMID: 31669619 | PMCID: PMC6934893
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Dichloroacetate-induced peripheral neuropathy.
Stacpoole PW, Martyniuk CJ, James MO, Calcutt NA
Int Rev Neurobiol, 145:211-238, 11 Jun 2019
Cited by: 26 articles | PMID: 31208525
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Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.
McCall CE, Zabalawi M, Liu T, Martin A, Long DL, Buechler NL, Arts RJW, Netea M, Yoza BK, Stacpoole PW, Vachharajani V
JCI Insight, 3(15):99292, 09 Aug 2018
Cited by: 32 articles | PMID: 30089711 | PMCID: PMC6129136
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Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.
Zhong G, James MO, Smeltz MG, Jahn SC, Langaee T, Simpson P, Stacpoole PW
Drug Metab Dispos, 46(8):1118-1128, 31 May 2018
Cited by: 6 articles | PMID: 29853471 | PMCID: PMC6038028
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Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration.
Jahn SC, Smeltz MG, Hu Z, Rowland-Faux L, Zhong G, Lorenzo RJ, Cisneros KV, Stacpoole PW, James MO
Biochem Pharmacol, 152:236-243, 05 Apr 2018
Cited by: 7 articles | PMID: 29626439 | PMCID: PMC5960630
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Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay.
Langaee T, Wagner R, Horne LP, Lawson LA, Becker C, Shahin M, Starostik P, Stacpoole PW
Genet Test Mol Biomarkers, 22(4):266-269, 19 Mar 2018
Cited by: 7 articles | PMID: 29641284
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Development of a novel observer reported outcome tool as the primary efficacy outcome measure for a rare disease randomized controlled trial.
Stacpoole PW, Shuster J, Thompson JLPS, Prather RA, Lawson LA, Zou B, Buchsbaum R, Nixon SJ
Mitochondrion, 42:59-63, 10 Nov 2017
Cited by: 4 articles | PMID: 29129554 | PMCID: PMC6587967
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Response to Newman et al.
Parikh S, Goldstein A, Karaa A, Koenig MK, Anselm I, Brunel-Guitton C, Christodoulou J, Cohen BH, Dimmock D, Enns GM, Falk MJ, Feigenbaum A, Frye RE, Ganesh J, Griesemer D, Haas R, Horvath R, Korson M, Kruer MC, [...] Chinnery PF
Genet Med, 19(12), 26 Oct 2017
Cited by: 0 articles | PMID: 29215644 | PMCID: PMC7787267
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1-25 of 213 results

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Search life-sciences literature (45,103,589 articles, preprints and more)

Search results

The pyruvate dehydrogenase complex at the epigenetic crossroads of acetylation and lactylation.

Clinical physiology and pharmacology of GSTZ1/MAAI.

The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat.

In-vivo magnetic resonance spectroscopy of lactate as a non-invasive biomarker of dichloroacetate activity in cancer and non-cancer central nervous system disorders.

Sepsis, pyruvate, and mitochondria energy supply chain shortage.

Dichloroacetate improves systemic energy balance and feeding behavior during sepsis.

Sodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor.

Dichloroacetate improves systemic energy balance and feeding behavior during sepsis

Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction.

Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1.

Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.

Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses.

Mitochondrial diseases in North America: An analysis of the NAMDC Registry.

Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.

Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes.

Mitochondrial Glutathione Transferase Zeta 1 Is Inactivated More Rapidly by Dichloroacetate than the Cytosolic Enzyme in Adult and Juvenile Rat Liver.

The changing landscape of clinical trials for mitochondrial diseases: 2011 to present.

Dichloroacetate-induced peripheral neuropathy.

Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.

Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.

Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration.

Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay.

Development of a novel observer reported outcome tool as the primary efficacy outcome measure for a rare disease randomized controlled trial.

Response to Newman et al.

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