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The use of Trichomonas vaginalis purine nucleoside phosphorylase to activate fludarabine in the treatment of solid tumors.
Parker WB, Allan PW, Waud WR, Hong J, Gilbert-Ross M, Achyut BR, Joshi D, Behbahani T, Rab R, Ealick SE, Sorscher EJ
Cancer Chemother Pharmacol, 85(3):573-583, 08 Jan 2020
Cited by: 6 articles | PMID: 31915968 | PMCID: PMC7039746
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Thiarabine, 1-(4-Thio-β-D-arabinofuranosyl)cytosine. A Deoxycytidine Analog With Excellent Anticancer Activity.
Parker WB, Waud WR, Secrist JA
Curr Med Chem, 22(34):3881-3896, 01 Jan 2015
Cited by: 3 articles | PMID: 26597061
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In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase.
Sorscher EJ, Hong JS, Allan PW, Waud WR, Parker WB
Cancer Chemother Pharmacol, 70(2):321-329, 04 Jul 2012
Cited by: 19 articles | PMID: 22760227 | PMCID: PMC3423194
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Isolation and characterization of a murine P388 leukemia line resistant to thiarabine.
Waud WR, Parker WB, Gilbert KS, Secrist JA
Nucleosides Nucleotides Nucleic Acids, 31(1):14-27, 01 Jan 2012
Cited by: 1 article | PMID: 22257207
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Preclinical combination therapy of clofarabine plus radiation.
Stackhouse MA, Gilbert KS, Scoggins JW, Waud WR
Nucleosides Nucleotides Nucleic Acids, 31(9):692-705, 01 Jan 2012
Cited by: 3 articles | PMID: 23004932
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Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.
Lin C, Lu W, Zhai L, Bethea T, Berry K, Qu Z, Waud WR, Li Y
FEBS Lett, 585(19):3120-3125, 05 Sep 2011
Cited by: 25 articles | PMID: 21907199 | PMCID: PMC3183310
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Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway.
Lu W, Lin C, Roberts MJ, Waud WR, Piazza GA, Li Y
PLoS One, 6(12):e29290, 16 Dec 2011
Cited by: 128 articles | PMID: 22195040 | PMCID: PMC3241710
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Preclinical antitumor activity of thiarabine in human leukemia and lymphoma xenograft models.
Waud WR, Gilbert KS, Secrist JA
Nucleosides Nucleotides Nucleic Acids, 31(9):647-660, 01 Jan 2012
Cited by: 0 articles | PMID: 23004929
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Preclinical combination therapy of thiarabine plus various clinical anticancer agents.
Waud WR, Gilbert KS, Secrist JA
Nucleosides Nucleotides Nucleic Acids, 31(8):630-646, 01 Jan 2012
Cited by: 2 articles | PMID: 22908953
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Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides.
Hassan AE, Abou-Elkhair RA, Riordan JM, Allan PW, Parker WB, Khare R, Waud WR, Montgomery JA, Secrist JA
Eur J Med Chem, 47(1):167-174, 04 Nov 2011
Cited by: 8 articles | PMID: 22112758 | PMCID: PMC3259247
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Isolation and characterization of a murine P388 leukemia line resistant to clofarabine.
Waud WR, Gilbert KS, Parker WB, Secrist JA
Nucleosides Nucleotides Nucleic Acids, 30(11):826-838, 01 Nov 2011
Cited by: 0 articles | PMID: 22060549
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Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies.
Bertino JR, Waud WR, Parker WB, Lubin M
Cancer Biol Ther, 11(7):627-632, 01 Apr 2011
Cited by: 84 articles | PMID: 21301207 | PMCID: PMC3084968
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Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase.
Parker WB, Allan PW, Waud WR, Hong JS, Sorscher EJ
Cancer Gene Ther, 18(6):390-398, 11 Mar 2011
Cited by: 16 articles | PMID: 21394111 | PMCID: PMC3096718
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Lack of in vivo cross-resistance with 4'-thio-ara-C against drug-resistant murine P388 and L1210 leukemias.
Waud WR, Gilbert KS, Secrist JA
Cancer Chemother Pharmacol, 68(2):399-403, 11 Nov 2010
Cited by: 3 articles | PMID: 21069340 | PMCID: PMC3128691
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BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors.
Adams DJ, Waud WR, Wani MC, Manikumar G, Flowers JL, Driscoll TA, Morgan LR
Cancer Chemother Pharmacol, 67(4):855-865, 22 Jun 2010
Cited by: 3 articles | PMID: 20567829 | PMCID: PMC2982901
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Synthesis and anticancer evaluation of 4'-C-methyl-2'-fluoro arabino nucleosides.
Tiwari KN, Shortnacy-Fowler AT, Parker WB, Waud WR, Secrist JA
Nucleosides Nucleotides Nucleic Acids, 28(5):657-677, 01 May 2009
Cited by: 3 articles | PMID: 20183608
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Carbonate and carbamate derivatives of 4-demethylpenclomedine as novel anticancer agents.
Morgan LR, Struck RF, Waud WR, LeBlanc B, Rodgers AH, Jursic BS
Cancer Chemother Pharmacol, 64(4):829-835, 03 Mar 2009
Cited by: 3 articles | PMID: 19255760 | PMCID: PMC2717391
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Enhancement of the in vivo antitumor activity of clofarabine by 1-beta-D-[4-thio-arabinofuranosyl]-cytosine.
Parker WB, Shaddix SC, Gilbert KS, Shepherd RV, Waud WR
Cancer Chemother Pharmacol, 64(2):253-261, 11 Nov 2008
Cited by: 6 articles | PMID: 19002461
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In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase.
Brooks WH, McCloskey DE, Daniel KG, Ealick SE, Secrist JA, Waud WR, Pegg AE, Guida WC
J Chem Inf Model, 47(5):1897-1905, 04 Aug 2007
Cited by: 11 articles | PMID: 17676832
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Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation.
Reynolds RC, Campbell SR, Fairchild RG, Kisliuk RL, Micca PL, Queener SF, Riordan JM, Sedwick WD, Waud WR, Leung AK, Dixon RW, Suling WJ, Borhani DW
J Med Chem, 50(14):3283-3289, 15 Jun 2007
Cited by: 30 articles | PMID: 17569517
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The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems.
Goldsmith ME, Aguila A, Steadman K, Martinez A, Steinberg SM, Alley MC, Waud WR, Bates SE, Fojo T
Mol Cancer Ther, 6(2):496-505, 01 Feb 2007
Cited by: 14 articles | PMID: 17308048
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Sorafenib is efficacious and tolerated in combination with cytotoxic or cytostatic agents in preclinical models of human non-small cell lung carcinoma.
Carter CA, Chen C, Brink C, Vincent P, Maxuitenko YY, Gilbert KS, Waud WR, Zhang X
Cancer Chemother Pharmacol, 59(2):183-195, 25 May 2006
Cited by: 54 articles | PMID: 16724239
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Long intracellular retention of 4'-thio-arabinofuranosylcytosine 5'-triphosphate as a critical factor for the anti-solid tumor activity of 4'-thio-arabinofuranosylcytosine.
Someya H, Waud WR, Parker WB
Cancer Chemother Pharmacol, 57(6):772-780, 23 Sep 2005
Cited by: 9 articles | PMID: 16180016
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Thiolo-, thiono- and dithiocarbonate and thiocarbamate derivatives of demethylpenclomedine as novel anticancer agents.
Struck RF, Waud WR
Cancer Chemother Pharmacol, 57(2):180-184, 11 Aug 2005
Cited by: 1 article | PMID: 16096790
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Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy.
Bharara S, Sorscher EJ, Gillespie GY, Lindsey JR, Hong JS, Curlee KV, Allan PW, Gadi VK, Alexander SA, Secrist JA, Parker WB, Waud WR
Hum Gene Ther, 16(3):339-347, 01 Mar 2005
Cited by: 19 articles | PMID: 15812229
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