AUTH:"Welters MJP" - Search results

Monocyte infiltration is an independent positive prognostic biomarker in vulvar squamous cell carcinoma.

Abdulrahman Z, Kortekaas KE, Welters MJP, van Poelgeest MIE, van der Burg SH

Cancer Immunol Immunother, 73(9):166, 02 Jul 2024

Cited by: 0 articles | PMID: 38954042 | PMCID: PMC11219697

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APOLLO: neo-adjuvant pembrolizumab for primary vulvar squamous cell carcinoma-a multicenter, single-arm, phase II, clinical proof-of-concept study.

van Poelgeest MIE, Kortekaas KE, van Doorn HC, Oonk M, Nijman HW, Boere I, Eerkens AL, Reyners AKL, Ewing-Graham PC, Bart J, Bosse T, Welters MJP, Kroep JR, van der Burg SH

Int J Gynecol Cancer, ijgc-2024-005523, 02 Jul 2024

Cited by: 0 articles | PMID: 38909994

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Autoantibody-positivity before and seroconversion during treatment with anti-PD-1 is associated with immune-related adverse events in patients with melanoma.

Borgers JSW, van Wesemael TJ, Gelderman KA, Rispens T, Verdegaal EME, Moes DJAR, Korse CM, Kapiteijn E, Welters MJP, van der Burg SH, van Houdt WJ, van Thienen JV, Haanen JBAG, van der Woude D

J Immunother Cancer, 12(6):e009215, 30 Jun 2024

Cited by: 0 articles | PMID: 38945553 | PMCID: PMC11216046

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CD4⁺ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors.

Lei X, de Groot DC, Welters MJP, de Wit T, Schrama E, van Eenennaam H, Santegoets SJ, Oosenbrug T, van der Veen A, Vos JL, Zuur CL, de Miranda NFCC, Jacobs H, van der Burg SH, Borst J, Xiao Y

Cell Mol Immunol, 21(4):374-392, 21 Feb 2024

Cited by: 4 articles | PMID: 38383773 | PMCID: PMC10978876

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Neutralizing Antibodies Impair the Oncolytic Efficacy of Reovirus but Permit Effective Combination with T cell-Based Immunotherapies.

Groeneveldt C, Kinderman P, Griffioen L, Rensing O, Labrie C, van den Wollenberg DJM, Hoeben RC, Coffey M, Loghmani H, Verdegaal EME, Welters MJP, van der Burg SH, van Hall T, van Montfoort N

Cancer Immunol Res, 12(3):334-349, 01 Mar 2024

Cited by: 1 article | PMID: 38194598 | PMCID: PMC10911706

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Timed adoptive T cell transfer during chemotherapy in patients with recurrent platinum-sensitive epithelial ovarian cancer.

Verdegaal EME, Santegoets SJ, Welters MJP, de Bruin L, Visser M, van der Minne CE, de Kok PM, Loof NM, Boekestijn S, Roozen I, Westra IM, Meij P, Van der Burg SH, Kroep JR

J Immunother Cancer, 11(11):e007697, 01 Nov 2023

Cited by: 2 articles | PMID: 37949617 | PMCID: PMC10649798

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The combined HPV16-E2/E6/E7 T cell response in oropharyngeal cancer predicts superior survival.

Santegoets SJ, Stolk A, Welters MJP, van der Burg SH

Cell Rep Med, 4(11):101262, 03 Nov 2023

Cited by: 1 article | PMID: 37924817 | PMCID: PMC10694628

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Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment.

Haake M, Haack B, Schäfer T, Harter PN, Mattavelli G, Eiring P, Vashist N, Wedekink F, Genssler S, Fischer B, Dahlhoff J, Mokhtari F, Kuzkina A, Welters MJP, Benz TM, Sorger L, Thiemann V, Almanzar G, Selle M, [...] Wischhusen J

Nat Commun, 14(1):4253, 20 Jul 2023

Cited by: 13 articles | PMID: 37474523 | PMCID: PMC10359308

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Therapeutic Vaccination against Human Papillomavirus Type 16 for the Treatment of High-Grade Anal Intraepithelial Neoplasia in HIV+ Men.

Gosens KCM, van der Burg SH, Welters MJP, Boekestijn S, Loof NM, Quint WGV, van Noesel CJM, van der Wal AC, Richel O, Krebber WJTA, Melief CJM, de Vries HJC, Prins JM

Clin Cancer Res, 29(20):4109-4117, 01 Oct 2023

Cited by: 1 article | PMID: 37540563

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The common HLA class I-restricted tumor-infiltrating T cell response in HPV16-induced cancer.

Santegoets SJ, Welters MJP, Schrikkema DS, Freriks MR, Kok H, Weissbrich B, van den Branden A, Linnemann C, Schumacher TN, Adhikary S, Bendle G, van der Burg SH

Cancer Immunol Immunother, 72(6):1553-1565, 16 Dec 2022

Cited by: 5 articles | PMID: 36526910 | PMCID: PMC10198845

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Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions.

Speetjens FM, Welters MJP, Slingerland M, van Poelgeest MIE, de Vos van Steenwijk PJ, Roozen I, Boekestijn S, Loof NM, Zom GG, Valentijn ARPM, Krebber WJ, Meeuwenoord NJ, Janssen CAH, Melief CJM, van der Marel GA, Filippov DV, van der Burg SH, Gelderblom H, Ossendorp F

J Immunother Cancer, 10(10):e005016, 01 Oct 2022

Cited by: 10 articles | PMID: 36261215 | PMCID: PMC9582304

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T and NK Cells in IL2RG-Deficient Patient 50 Years After Hematopoietic Stem Cell Transplantation.

Melsen JE, van Ostaijen-Ten Dam MM, van den Akker EB, Welters MJP, Heezen KC, Pico-Knijnenburg I, Kolijn PM, Bredius RGM, van Doorn R, Langerak AW, Schilham MW, Lankester AC

J Clin Immunol, 42(6):1205-1222, 09 May 2022

Cited by: 3 articles | PMID: 35527320 | PMCID: PMC9537207

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Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival.

Abdulrahman Z, Santegoets SJ, Sturm G, Charoentong P, Ijsselsteijn ME, Somarakis A, Höllt T, Finotello F, Trajanoski Z, van Egmond SL, Mustafa DAM, Welters MJP, de Miranda NFCC, van der Burg SH

J Immunother Cancer, 10(2):e004346, 01 Feb 2022

Cited by: 16 articles | PMID: 35217577 | PMCID: PMC8883276

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CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors.

Duurland CL, Santegoets SJ, Abdulrahman Z, Loof NM, Sturm G, Wesselink TH, Arens R, Boekestijn S, Ehsan I, van Poelgeest MIE, Finotello F, Hackl H, Trajanoski Z, Ten Dijke P, Braud VM, Welters MJP, van der Burg SH

J Immunother Cancer, 10(1):e003995, 01 Jan 2022

Cited by: 18 articles | PMID: 35039463 | PMCID: PMC8765066

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Predictive Biomarkers for Outcomes of Immune Checkpoint Inhibitors (ICIs) in Melanoma: A Systematic Review.

Baltussen JC, Welters MJP, Verdegaal EME, Kapiteijn E, Schrader AMR, Slingerland M, Liefers GJ, van der Burg SH, Portielje JEA, de Glas NA

Cancers (Basel), 13(24):6366, 18 Dec 2021

Cited by: 11 articles | PMID: 34944986 | PMCID: PMC8699321

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PROTECT: Prospective Phase-II-Trial Evaluating Adaptive Proton Therapy for Cervical Cancer to Reduce the Impact on Morbidity and the Immune System.

Corbeau A, Nout RA, Mens JWM, Horeweg N, Godart J, Kerkhof EM, Kuipers SC, van Poelgeest MIE, Kroep JR, Boere IA, van Doorn HC, Hoogeman MS, van der Heide UA, Putter H, Welters MJP, van der Burg SH, Creutzberg CL, de Boer SM

Cancers (Basel), 13(20):5179, 15 Oct 2021

Cited by: 6 articles | PMID: 34680328 | PMCID: PMC8533850

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Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers.

Otterhaug T, Janetzki S, Welters MJP, Håkerud M, Nedberg AG, Edwards VT, Boekestijn S, Loof NM, Selbo PK, Olivecrona H, van der Burg SH, Høgset A

Front Immunol, 11:576756, 08 Jan 2021

Cited by: 11 articles | PMID: 33488576 | PMCID: PMC7819858

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Interferon-γ and IL-5 associated cell-mediated immune responses to HPV16 E2 and E6 distinguish between persistent oral HPV16 infections and noninfected mucosa.

Paaso A, Koskimaa HM, Welters MJP, Kero K, Rautava J, Syrjänen K, van der Burg SH, Syrjänen S

Clin Exp Dent Res, 7(5):903-913, 09 Jan 2021

Cited by: 5 articles | PMID: 33421352 | PMCID: PMC8543460

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The Tumor Microenvironment and Immunotherapy of Oropharyngeal Squamous Cell Carcinoma.

Welters MJP, Santegoets SJ, van der Burg SH

Front Oncol, 10:545385, 21 Dec 2020

Cited by: 18 articles | PMID: 33425717 | PMCID: PMC7793705

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Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer.

Hurkmans DP, Verdegaal EME, Hogan SA, de Wijn R, Hovestad L, van den Heuvel DMA, Ruijtenbeek R, Welters MJP, van Brakel M, Basak EA, Pinedo HM, Lamers CHJ, van de Werken HJG, Groten JP, Debets R, Levesque MP, Dummer R, Kapiteijn E, Mathijssen RHJ, [...] van der Burg SH

J Immunother Cancer, 8(2):e001607, 01 Dec 2020

Cited by: 6 articles | PMID: 33427690 | PMCID: PMC7757459

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CD39 Identifies the CD4⁺ Tumor-Specific T-cell Population in Human Cancer.

Kortekaas KE, Santegoets SJ, Sturm G, Ehsan I, van Egmond SL, Finotello F, Trajanoski Z, Welters MJP, van Poelgeest MIE, van der Burg SH

Cancer Immunol Res, 8(10):1311-1321, 05 Aug 2020

Cited by: 66 articles | PMID: 32759363

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Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial.

de Groot S, Lugtenberg RT, Cohen D, Welters MJP, Ehsan I, Vreeswijk MPG, Smit VTHBM, de Graaf H, Heijns JB, Portielje JEA, van de Wouw AJ, Imholz ALT, Kessels LW, Vrijaldenhoven S, Baars A, Kranenbarg EM, Carpentier MD, Putter H, van der Hoeven JJM, [...] Dutch Breast Cancer Research Group (BOOG)

Nat Commun, 11(1):3083, 23 Jun 2020

Cited by: 120 articles | PMID: 32576828 | PMCID: PMC7311547

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Strong vaccine responses during chemotherapy are associated with prolonged cancer survival.

Melief CJM, Welters MJP, Vergote I, Kroep JR, Kenter GG, Ottevanger PB, Tjalma WAA, Denys H, van Poelgeest MIE, Nijman HW, Reyners AKL, Velu T, Goffin F, Lalisang RI, Loof NM, Boekestijn S, Krebber WJ, Hooftman L, Visscher S, [...] van der Burg SH

Sci Transl Med, 12(535):eaaz8235, 01 Mar 2020

Cited by: 65 articles | PMID: 32188726

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Long-term HPV-specific immune response after one versus two and three doses of bivalent HPV vaccination in Dutch girls.

Pasmans H, Schurink-Van't Klooster TM, Bogaard MJM, van Rooijen DM, de Melker HE, Welters MJP, van der Burg SH, van der Klis FRM, Buisman AM

Vaccine, 37(49):7280-7288, 28 Sep 2019

Cited by: 12 articles | PMID: 31575492

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NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines.

van Montfoort N, Borst L, Korrer MJ, Sluijter M, Marijt KA, Santegoets SJ, van Ham VJ, Ehsan I, Charoentong P, André P, Wagtmann N, Welters MJP, Kim YJ, Piersma SJ, van der Burg SH, van Hall T

Cell, 175(7):1744-1755.e15, 29 Nov 2018

Cited by: 164 articles | PMID: 30503208 | PMCID: PMC6354585

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Monocyte infiltration is an independent positive prognostic biomarker in vulvar squamous cell carcinoma.

APOLLO: neo-adjuvant pembrolizumab for primary vulvar squamous cell carcinoma-a multicenter, single-arm, phase II, clinical proof-of-concept study.

Autoantibody-positivity before and seroconversion during treatment with anti-PD-1 is associated with immune-related adverse events in patients with melanoma.

CD4⁺ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors.

Neutralizing Antibodies Impair the Oncolytic Efficacy of Reovirus but Permit Effective Combination with T cell-Based Immunotherapies.

Timed adoptive T cell transfer during chemotherapy in patients with recurrent platinum-sensitive epithelial ovarian cancer.

The combined HPV16-E2/E6/E7 T cell response in oropharyngeal cancer predicts superior survival.

Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment.

Therapeutic Vaccination against Human Papillomavirus Type 16 for the Treatment of High-Grade Anal Intraepithelial Neoplasia in HIV+ Men.

The common HLA class I-restricted tumor-infiltrating T cell response in HPV16-induced cancer.

Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions.

T and NK Cells in IL2RG-Deficient Patient 50 Years After Hematopoietic Stem Cell Transplantation.

Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival.

CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors.

Predictive Biomarkers for Outcomes of Immune Checkpoint Inhibitors (ICIs) in Melanoma: A Systematic Review.

PROTECT: Prospective Phase-II-Trial Evaluating Adaptive Proton Therapy for Cervical Cancer to Reduce the Impact on Morbidity and the Immune System.

Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers.

Interferon-γ and IL-5 associated cell-mediated immune responses to HPV16 E2 and E6 distinguish between persistent oral HPV16 infections and noninfected mucosa.

The Tumor Microenvironment and Immunotherapy of Oropharyngeal Squamous Cell Carcinoma.

Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer.

CD39 Identifies the CD4⁺ Tumor-Specific T-cell Population in Human Cancer.

Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial.

Strong vaccine responses during chemotherapy are associated with prolonged cancer survival.

Long-term HPV-specific immune response after one versus two and three doses of bivalent HPV vaccination in Dutch girls.

NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines.

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