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Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators.
Bellott DW, Hughes JF, Skaletsky H, Brown LG, Pyntikova T, Cho TJ, Koutseva N, Zaghlul S, Graves T, Rock S, Kremitzki C, Fulton RS, Dugan S, Ding Y, Morton D, Khan Z, Lewis L, Buhay C, Wang Q, [...] Page DC
Nature, 508(7497):494-499, 01 Apr 2014
Cited by: 397 articles | PMID: 24759411 | PMCID: PMC4139287
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Independent specialization of the human and mouse X chromosomes for the male germ line.
Mueller JL, Skaletsky H, Brown LG, Zaghlul S, Rock S, Graves T, Auger K, Warren WC, Wilson RK, Page DC
Nat Genet, 45(9):1083-1087, 21 Jul 2013
Cited by: 117 articles | PMID: 23872635 | PMCID: PMC3758364
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An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells.
Sheng Q, Liu X, Fleming E, Yuan K, Piao H, Chen J, Moustafa Z, Thomas RK, Greulich H, Schinzel A, Zaghlul S, Batt D, Ettenberg S, Meyerson M, Schoeberl B, Kung AL, Hahn WC, Drapkin R, Livingston DM, Liu JF
Cancer Cell, 17(3):298-310, 01 Mar 2010
Cited by: 157 articles | PMID: 20227043 | PMCID: PMC2897158
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HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice.
Kim WY, Perera S, Zhou B, Carretero J, Yeh JJ, Heathcote SA, Jackson AL, Nikolinakos P, Ospina B, Naumov G, Brandstetter KA, Weigman VJ, Zaghlul S, Hayes DN, Padera RF, Heymach JV, Kung AL, Sharpless NE, Kaelin WG, Wong KK
J Clin Invest, 119(8):2160-2170, 01 Aug 2009
Cited by: 100 articles | PMID: 19662677 | PMCID: PMC2719950
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Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
Shimamura T, Li D, Ji H, Haringsma HJ, Liniker E, Borgman CL, Lowell AM, Minami Y, McNamara K, Perera SA, Zaghlul S, Thomas RK, Greulich H, Kobayashi S, Chirieac LR, Padera RF, Kubo S, Takahashi M, Tenen DG, [...] Shapiro GI
Cancer Res, 68(14):5827-5838, 01 Jul 2008
Cited by: 101 articles | PMID: 18632637 | PMCID: PMC3272303
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HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.
Perera SA, Li D, Shimamura T, Raso MG, Ji H, Chen L, Borgman CL, Zaghlul S, Brandstetter KA, Kubo S, Takahashi M, Chirieac LR, Padera RF, Bronson RT, Shapiro GI, Greulich H, Meyerson M, Guertler U, Chesa PG, [...] Wong KK
Proc Natl Acad Sci U S A, 106(2):474-479, 02 Jan 2009
Cited by: 112 articles | PMID: 19122144 | PMCID: PMC2626727
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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, [...] DePinho RA
Nature, 447(7147):966-971, 21 May 2007
Cited by: 286 articles | PMID: 17515920 | PMCID: PMC2714968
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Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models.
Ji H, Wang Z, Perera SA, Li D, Liang MC, Zaghlul S, McNamara K, Chen L, Albert M, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Thomas RK, Garraway LA, Jänne PA, Johnson BE, Chin L, Wong KK
Cancer Res, 67(10):4933-4939, 01 May 2007
Cited by: 109 articles | PMID: 17510423
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Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas.
Li D, Ji H, Zaghlul S, McNamara K, Liang MC, Shimamura T, Kubo S, Takahashi M, Chirieac LR, Padera RF, Scott AM, Jungbluth AA, Cavenee WK, Old LJ, Demetri GD, Wong KK
J Clin Invest, 117(2):346-352, 25 Jan 2007
Cited by: 34 articles | PMID: 17256054 | PMCID: PMC1770949
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Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy.
Li D, Shimamura T, Ji H, Chen L, Haringsma HJ, McNamara K, Liang MC, Perera SA, Zaghlul S, Borgman CL, Kubo S, Takahashi M, Sun Y, Chirieac LR, Padera RF, Lindeman NI, Jänne PA, Thomas RK, Meyerson ML, [...] Wong KK
Cancer Cell, 12(1):81-93, 01 Jul 2007
Cited by: 141 articles | PMID: 17613438
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