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A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial.
Noor NM, Lee JC, Bond S, Dowling F, Brezina B, Patel KV, Ahmad T, Banim PJ, Berrill JW, Cooney R, De La Revilla Negro J, de Silva S, Din S, Durai D, Gordon JN, Irving PM, Johnson M, Kent AJ, Kok KB, [...] PROFILE Study Group
Lancet Gastroenterol Hepatol, 9(5):415-427, 22 Feb 2024
Cited by: 15 articles | PMID: 38402895 | PMCID: PMC11001594
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Grp78 is required for intestinal Kras-dependent glycolysis proliferation and adenomagenesis.
Spaan CN, de Boer RJ, Smit WL, van der Meer JH, van Roest M, Vermeulen JL, Koelink PJ, Becker MA, Go S, Silva J, Faller WJ, van den Brink GR, Muncan V, Heijmans J
Life Sci Alliance, 6(11):e202301912, 29 Aug 2023
Cited by: 0 articles | PMID: 37643866 | PMCID: PMC10465924
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Translation initiation factor eIF2Bε promotes Wnt-mediated clonogenicity and global translation in intestinal epithelial cells.
Smit WL, de Boer RJ, Meijer BJ, Spaan CN, van Roest M, Koelink PJ, Koster J, Dekker E, Abbink TEM, van der Knaap MS, van den Brink GR, Muncan V, Heijmans J
Stem Cell Res, 55:102499, 11 Aug 2021
Cited by: 0 articles | PMID: 34399164
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Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis.
van der Meer JHM, de Boer RJ, Meijer BJ, Smit WL, Vermeulen JLM, Meisner S, van Roest M, Koelink PJ, Dekker E, Hakvoort TBM, Koster J, Hawinkels LJAC, Heijmans J, Struijs EA, Boermeester MA, van den Brink GR, Muncan V
Cell Death Dis, 12(10):897, 01 Oct 2021
Cited by: 5 articles | PMID: 34599156 | PMCID: PMC8486827
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Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2.
Meijer BJ, Smit WL, Koelink PJ, Westendorp BF, de Boer RJ, van der Meer JHM, Vermeulen JLM, Paton JC, Paton AW, Qin J, Dekker E, Muncan V, van den Brink GR, Heijmans J
Sci Rep, 11(1):9892, 10 May 2021
Cited by: 9 articles | PMID: 33972635 | PMCID: PMC8111031
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Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation.
Westendorp F, Karpus ON, Koelink PJ, Vermeulen JLM, Meisner S, Koster J, Büller NVJA, Wildenberg ME, Muncan V, van den Brink GR
Oncogene, 40(9):1628-1643, 21 Jan 2021
Cited by: 5 articles | PMID: 33479497
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Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity.
Smit WL, Spaan CN, Johannes de Boer R, Ramesh P, Martins Garcia T, Meijer BJ, Vermeulen JLM, Lezzerini M, MacInnes AW, Koster J, Medema JP, van den Brink GR, Muncan V, Heijmans J
Proc Natl Acad Sci U S A, 117(41):25560-25570, 28 Sep 2020
Cited by: 37 articles | PMID: 32989144 | PMCID: PMC7568276
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ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair.
Meijer BJ, Giugliano FP, Baan B, van der Meer JHM, Meisner S, van Roest M, Koelink PJ, de Boer RJ, Jones N, Breitwieser W, van der Wel NN, Wildenberg ME, van den Brink GR, Heijmans J, Muncan V
Cell Mol Gastroenterol Hepatol, 10(1):23-42, 17 Jan 2020
Cited by: 8 articles | PMID: 31958521 | PMCID: PMC7210476
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A prospective study comparing patient-reported outcomes in Crohn's disease.
Hoekman DR, Löwenberg M, van den Brink GR, Ponsioen CY, Benninga MA, D'Haens GR
Eur J Gastroenterol Hepatol, 32(1):38-44, 01 Jan 2020
Cited by: 2 articles | PMID: 31651651 | PMCID: PMC6903328
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A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration.
Montenegro-Miranda PS, van der Meer JHM, Jones C, Meisner S, Vermeulen JLM, Koster J, Wildenberg ME, Heijmans J, Boudreau F, Ribeiro A, van den Brink GR, Muncan V
Cell Mol Gastroenterol Hepatol, 10(2):209-223, 05 Mar 2020
Cited by: 19 articles | PMID: 32145468 | PMCID: PMC7301200
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MEX3A regulates Lgr5⁺ stem cell maintenance in the developing intestinal epithelium.
Pereira B, Amaral AL, Dias A, Mendes N, Muncan V, Silva AR, Thibert C, Radu AG, David L, Máximo V, van den Brink GR, Billaud M, Almeida R
EMBO Rep, 21(4):e48938, 13 Feb 2020
Cited by: 16 articles | PMID: 32052574 | PMCID: PMC7132344
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Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling.
Spaan CN, Smit WL, van Lidth de Jeude JF, Meijer BJ, Muncan V, van den Brink GR, Heijmans J
Cell Death Dis, 10(7):490, 21 Jun 2019
Cited by: 51 articles | PMID: 31227689 | PMCID: PMC6588629
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Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling.
Koelink PJ, Bloemendaal FM, Li B, Westera L, Vogels EWM, van Roest M, Gloudemans AK, van 't Wout AB, Korf H, Vermeire S, Te Velde AA, Ponsioen CY, D'Haens GR, Verbeek JS, Geiger TL, Wildenberg ME, van den Brink GR
Gut, 69(6):1053-1063, 10 Sep 2019
Cited by: 74 articles | PMID: 31506328 | PMCID: PMC7282553
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Evaluation of optimal biopsy location for assessment of histological activity, transcriptomic and immunohistochemical analyses in patients with active Crohn's disease.
Novak G, Stevens T, Van Viegen T, Bossuyt P, Štabuc B, Jeyarajah J, Zou G, Gaemers IC, McKee TD, Fu F, Shackelton LM, Khanna R, van den Brink GR, Sandborn WJ, Feagan BG, Pai RK, Jairath V, Vande Casteele N, D'Haens G
Aliment Pharmacol Ther, 49(11):1401-1409, 15 Apr 2019
Cited by: 8 articles | PMID: 30983024
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Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth.
Karpus ON, Westendorp BF, Vermeulen JLM, Meisner S, Koster J, Muncan V, Wildenberg ME, van den Brink GR
Cell Rep, 26(13):3698-3708.e5, 01 Mar 2019
Cited by: 50 articles | PMID: 30917322
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Persistent Mesorectal Inflammatory Activity is Associated With Complications After Proctectomy in Crohn's Disease.
de Groof EJ, van der Meer JHM, Tanis PJ, de Bruyn JR, van Ruler O, D'Haens GRAM, van den Brink GR, Bemelman WA, Wildenberg ME, Buskens CJ
J Crohns Colitis, 13(3):285-293, 01 Mar 2019
Cited by: 22 articles | PMID: 30203027
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Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation.
van Lidth de Jeude JF, Spaan CN, Meijer BJ, Smit WL, Soeratram TTD, Wielenga MCB, Westendorp BF, Lee AS, Meisner S, Vermeulen JLM, Wildenberg ME, van den Brink GR, Muncan V, Heijmans J
Cancer Res, 78(21):6098-6106, 19 Sep 2018
Cited by: 9 articles | PMID: 30232220 | PMCID: PMC8272399
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Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning.
Navis M, Martins Garcia T, Renes IB, Vermeulen JL, Meisner S, Wildenberg ME, van den Brink GR, van Elburg RM, Muncan V
EMBO Rep, 20(2):e46221, 10 Dec 2018
Cited by: 27 articles | PMID: 30530633 | PMCID: PMC6362357
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Multiomics Analyses to Deliver the Most Effective Treatment to Every Patient With Inflammatory Bowel Disease.
Weersma RK, Xavier RJ, IBD Multi Omics Consortium, Vermeire S, Barrett JC
Gastroenterology, 155(5):e1-e4, 02 Aug 2018
Cited by: 14 articles | PMID: 30077628
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Colorectal tumor prevention by the progestin medroxyprogesterone acetate is critically dependent on postmenopausal status.
Meijer BJ, Wielenga MCB, Hoyer PB, Amos-Landgraf JM, Hakvoort TBM, Muncan V, Heijmans J, van den Brink GR
Oncotarget, 9(55):30561-30567, 17 Jul 2018
Cited by: 8 articles | PMID: 30093969 | PMCID: PMC6078141
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Development of Reliable, Valid and Responsive Scoring Systems for Endoscopy and Histology in Animal Models for Inflammatory Bowel Disease.
Koelink PJ, Wildenberg ME, Stitt LW, Feagan BG, Koldijk M, van 't Wout AB, Atreya R, Vieth M, Brandse JF, Duijst S, Te Velde AA, D'Haens GRAM, Levesque BG, van den Brink GR
J Crohns Colitis, 12(7):794-803, 01 Jun 2018
Cited by: 69 articles | PMID: 29608662 | PMCID: PMC6022651
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Fibrostenotic Phenotype of Myofibroblasts in Crohn's Disease is Dependent on Tissue Stiffness and Reversed by LOX Inhibition.
de Bruyn JR, van den Brink GR, Steenkamer J, Buskens CJ, Bemelman WA, Meisner S, Muncan V, Te Velde AA, D'Haens GR, Wildenberg ME
J Crohns Colitis, 12(7):849-859, 01 Jun 2018
Cited by: 22 articles | PMID: 29672662
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TNF-anti-TNF Immune Complexes Inhibit IL-12/IL-23 Secretion by Inflammatory Macrophages via an Fc-dependent Mechanism.
Bloemendaal FM, Koelink PJ, van Schie KA, Rispens T, Peters CP, Buskens CJ, van der Bilt JD, Bemelman WA, Korf H, Sabino JG, Ponsioen CY, Te Velde AA, D'Haens GRAM, Vermeire S, van den Brink GR, Wildenberg ME
J Crohns Colitis, 12(9):1122-1130, 01 Aug 2018
Cited by: 21 articles | PMID: 29860435
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Intestinal fibrosis is associated with lack of response to Infliximab therapy in Crohn's disease.
de Bruyn JR, Becker MA, Steenkamer J, Wildenberg ME, Meijer SL, Buskens CJ, Bemelman WA, Löwenberg M, Ponsioen CY, van den Brink GR, D'Haens GR
PLoS One, 13(1):e0190999, 24 Jan 2018
Cited by: 17 articles | PMID: 29364909 | PMCID: PMC5783363
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FcαRI co-stimulation converts human intestinal CD103⁺ dendritic cells into pro-inflammatory cells through glycolytic reprogramming.
Hansen IS, Krabbendam L, Bernink JH, Loayza-Puch F, Hoepel W, van Burgsteden JA, Kuijper EC, Buskens CJ, Bemelman WA, Zaat SAJ, Agami R, Vidarsson G, van den Brink GR, de Jong EC, Wildenberg ME, Baeten DLP, Everts B, den Dunnen J
Nat Commun, 9(1):863, 28 Feb 2018
Cited by: 26 articles | PMID: 29491406 | PMCID: PMC5830413
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