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Search life-sciences literature (45,103,589 articles, preprints and more)

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Evaluation of a Covalent Library of Diverse Warheads (CovLib) Binding to JNK3, USP7, or p53.
Klett T, Schwer M, Ernst LN, Engelhardt MU, Jaag SJ, Masberg B, Knappe C, Lämmerhofer M, Gehringer M, Boeckler FM
Drug Des Devel Ther, 18:2653-2679, 01 Jul 2024
Cited by: 0 articles | PMID: 38974119
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Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
Balourdas DI, Markl AM, Krämer A, Settanni G, Joerger AC
Cell Death Dis, 15(6):408, 11 Jun 2024
Cited by: 1 article | PMID: 38862470
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Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress.
Howes AC, Perisic O, Williams RL
Sci Adv, 9(39):eadi8291, 27 Sep 2023
Cited by: 8 articles | PMID: 37756394 | PMCID: PMC10530080
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Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven by Different p53 Mutants.
Chachad D, Patel LR, Recio CV, Pourebrahim R, Whitley EM, Wang W, Su X, Xu A, Lee DF, Lozano G
Cancer Res, 83(14):2297-2311, 01 Jul 2023
Cited by: 3 articles | PMID: 37205631 | PMCID: PMC10524763
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OPUS-Mut: Studying the Effect of Protein Mutation through Side-Chain Modeling.
Xu G, Wang Q, Ma J
J Chem Theory Comput, 19(5):1629-1640, 22 Feb 2023
Cited by: 1 article | PMID: 36813264 | PMCID: PMC10018731
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Targeting p53 pathways: mechanisms, structures, and advances in therapy.
Wang H, Guo M, Wei H, Chen Y
Signal Transduct Target Ther, 8(1):92, 01 Mar 2023
Cited by: 122 articles | PMID: 36859359 | PMCID: PMC9977964
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Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C.
Stahlecker J, Klett T, Schwer M, Jaag S, Dammann M, Ernst LN, Braun MB, Zimmermann MO, Kramer M, Lämmerhofer M, Stehle T, Coles M, Boeckler FM
RSC Med Chem, 13(12):1575-1586, 20 Oct 2022
Cited by: 5 articles | PMID: 36561072 | PMCID: PMC9749929
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Insights into Allosteric Mechanisms of the Lung-Enriched p53 Mutants V157F and R158L.
Lei J, Li X, Cai M, Guo T, Lin D, Deng X, Li Y
Int J Mol Sci, 23(17):10100, 03 Sep 2022
Cited by: 2 articles | PMID: 36077492 | PMCID: PMC9456101
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Protein of a thousand faces: The tumor-suppressive and oncogenic responses of p53.
Marques MA, de Andrade GC, Silva JL, de Oliveira GAP
Front Mol Biosci, 9:944955, 25 Aug 2022
Cited by: 5 articles | PMID: 36090037 | PMCID: PMC9452956
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Structural Basis of Mutation-Dependent p53 Tetramerization Deficiency.
Rigoli M, Spagnolli G, Lorengo G, Monti P, Potestio R, Biasini E, Inga A
Int J Mol Sci, 23(14):7960, 19 Jul 2022
Cited by: 1 article | PMID: 35887312 | PMCID: PMC9316806
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Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog.
Zhang Q, Balourdas DI, Baron B, Senitzki A, Haran TE, Wiman KG, Soussi T, Joerger AC
Cell Death Dis, 13(3):214, 07 Mar 2022
Cited by: 9 articles | PMID: 35256607 | PMCID: PMC8901663
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Caffeic acid phenethyl ester (CAPE) confers wild type p53 function in p53^Y220C mutant: bioinformatics and experimental evidence.
Radhakrishnan N, Dhanjal JK, Sari AN, Ishida Y, Terao K, Kaul SC, Sundar D, Wadhwa R
Discov Oncol, 12(1):64, 20 Dec 2021
Cited by: 4 articles | PMID: 35201513 | PMCID: PMC8777538
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Structural and Drug Targeting Insights on Mutant p53.
Gomes AS, Ramos H, Inga A, Sousa E, Saraiva L
Cancers (Basel), 13(13):3344, 03 Jul 2021
Cited by: 26 articles | PMID: 34283062 | PMCID: PMC8268744
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A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding.
Sun X, Dyson HJ, Wright PE
Proc Natl Acad Sci U S A, 118(1):e2021456118, 21 Dec 2020
Cited by: 25 articles | PMID: 33443163 | PMCID: PMC7817127
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Tumorigenic p53 mutants undergo common structural disruptions including conversion to α-sheet structure.
Bromley D, Daggett V
Protein Sci, 29(9):1983-1999, 17 Aug 2020
Cited by: 3 articles | PMID: 32715544 | PMCID: PMC7454552
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Deep phylogeny of cancer drivers and compensatory mutations.
Rochman ND, Wolf YI, Koonin EV
Commun Biol, 3(1):551, 02 Oct 2020
Cited by: 9 articles | PMID: 33009502 | PMCID: PMC7532533
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Prediction of secondary structure population and intrinsic disorder of proteins using multitask deep learning.
Ying X, Leier A, Marquez-Lago TT, Xie J, Jimeno Yepes AJ, Whisstock JC, Wilson C, Song J
AMIA Annu Symp Proc, 2020:1325-1334, 01 Jan 2020
Cited by: 0 articles | PMID: 33936509 | PMCID: PMC8075420
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The Rich World of p53 DNA Binding Targets: The Role of DNA Structure.
Brázda V, Fojta M
Int J Mol Sci, 20(22):E5605, 09 Nov 2019
Cited by: 28 articles | PMID: 31717504 | PMCID: PMC6888028
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Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
Bauer MR, Krämer A, Settanni G, Jones RN, Ni X, Khan Tareque R, Fersht AR, Spencer J, Joerger AC
ACS Chem Biol, 15(3):657-668, 21 Feb 2020
Cited by: 27 articles | PMID: 31990523 | PMCID: PMC7307883
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From uncertainty to pathogenicity: clinical and functional interrogation of a rare TP53 in-frame deletion.
Quinn EA, Maciaszek JL, Pinto EM, Phillips AH, Berdy D, Khandwala M, Upadhyaya SA, Zambetti GP, Kriwacki RW, Ellison DW, Nichols KE, Kesserwan C
Cold Spring Harb Mol Case Stud, 5(4):a003921, 01 Aug 2019
Cited by: 5 articles | PMID: 30886117 | PMCID: PMC6672031
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Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket.
Pradhan MR, Siau JW, Kannan S, Nguyen MN, Ouaray Z, Kwoh CK, Lane DP, Ghadessy F, Verma CS
Nucleic Acids Res, 47(4):1637-1652, 01 Feb 2019
Cited by: 20 articles | PMID: 30649466 | PMCID: PMC6393305
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Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain.
Krois AS, Dyson HJ, Wright PE
Proc Natl Acad Sci U S A, 115(48):E11302-E11310, 12 Nov 2018
Cited by: 61 articles | PMID: 30420502 | PMCID: PMC6275486
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The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.
Gomes AS, Trovão F, Andrade Pinheiro B, Freire F, Gomes S, Oliveira C, Domingues L, Romão MJ, Saraiva L, Carvalho AL
Int J Mol Sci, 19(4):E1184, 13 Apr 2018
Cited by: 10 articles | PMID: 29652801 | PMCID: PMC5979565
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Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer.
Pedrote MM, de Oliveira GAP, Felix AL, Mota MF, Marques MA, Soares IN, Iqbal A, Norberto DR, Gomes AMO, Gratton E, Cino EA, Silva JL
J Biol Chem, 293(29):11374-11387, 31 May 2018
Cited by: 14 articles | PMID: 29853637 | PMCID: PMC6065177
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From mutational inactivation to aberrant gain-of-function: Unraveling the structural basis of mutant p53 oncogenic transition.
Olotu FA, Soliman MES
J Cell Biochem, 119(3):2646-2652, 12 Dec 2017
Cited by: 18 articles | PMID: 29058783
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1-25 of 110 results

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Search life-sciences literature (45,103,589 articles, preprints and more)

Search results

Evaluation of a Covalent Library of Diverse Warheads (CovLib) Binding to JNK3, USP7, or p53.

Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.

Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress.

Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven by Different p53 Mutants.

OPUS-Mut: Studying the Effect of Protein Mutation through Side-Chain Modeling.

Targeting p53 pathways: mechanisms, structures, and advances in therapy.

Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C.

Insights into Allosteric Mechanisms of the Lung-Enriched p53 Mutants V157F and R158L.

Protein of a thousand faces: The tumor-suppressive and oncogenic responses of p53.

Structural Basis of Mutation-Dependent p53 Tetramerization Deficiency.

Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog.

Caffeic acid phenethyl ester (CAPE) confers wild type p53 function in p53^Y220C mutant: bioinformatics and experimental evidence.

Structural and Drug Targeting Insights on Mutant p53.

A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding.

Tumorigenic p53 mutants undergo common structural disruptions including conversion to α-sheet structure.

Deep phylogeny of cancer drivers and compensatory mutations.

Prediction of secondary structure population and intrinsic disorder of proteins using multitask deep learning.

The Rich World of p53 DNA Binding Targets: The Role of DNA Structure.

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.

From uncertainty to pathogenicity: clinical and functional interrogation of a rare TP53 in-frame deletion.

Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket.

Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain.

The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.

Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer.

From mutational inactivation to aberrant gain-of-function: Unraveling the structural basis of mutant p53 oncogenic transition.

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