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Search life-sciences literature (45,104,206 articles, preprints and more)

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Tau accumulation is cleared by the induced expression of VCP via autophagy.
Giong HK, Hyeon SJ, Lee JG, Cho HJ, Park U, Stein TD, Lee J, Yu K, Ryu H, Lee JS
Acta Neuropathol, 148(1):46, 24 Sep 2024
Cited by: 0 articles | PMID: 39316141 | PMCID: PMC11422276
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Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.
Nandi P, DeVore K, Wang F, Li S, Walker JD, Truong TT, LaPorte MG, Wipf P, Schlager H, McCleerey J, Paquette W, Columbres RCA, Gan T, Poh YP, Fromme P, Flint AJ, Wolf M, Huryn DM, Chou TF, Chiu PL
Commun Chem, 7(1):177, 09 Aug 2024
Cited by: 0 articles | PMID: 39122922 | PMCID: PMC11316111
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Fatty links between multisystem proteinopathy and small VCP-interacting protein.
Ramzan F, Kumar A, Abrar F, Gray RAV, Campbell ZE, Liao LMQ, Dang A, Akanni O, Guyn C, Martin DDO
Cell Death Discov, 10(1):358, 08 Aug 2024
Cited by: 0 articles | PMID: 39117616 | PMCID: PMC11310202
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Novel strategies in Parkinson's disease treatment: a review.
Mitchell CL, Kurouski D
Front Mol Neurosci, 17:1431079, 09 Aug 2024
Cited by: 1 article | PMID: 39183754 | PMCID: PMC11341544
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VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy.
Wang Z, Xiong S, Wu Z, Wang X, Gong Y, Zhu WG, Xu X
Autophagy, 20(9):2041-2054, 26 May 2024
Cited by: 0 articles | PMID: 38762759
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VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models.
Phan JM, Creekmore BC, Nguyen AT, Bershadskaya DD, Darwich NF, Mann CN, Lee EB
J Clin Invest, 134(14):e169039, 23 May 2024
Cited by: 4 articles | PMID: 38787785 | PMCID: PMC11257039
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Valosin-Containing Protein (VCP): A Review of Its Diverse Molecular Functions and Clinical Phenotypes.
Pontifex CS, Zaman M, Fanganiello RD, Shutt TE, Pfeffer G
Int J Mol Sci, 25(11):5633, 22 May 2024
Cited by: 1 article | PMID: 38891822 | PMCID: PMC11172259
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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol.
Wrobel L, Hoffmann JL, Li X, Rubinsztein DC
Sci Adv, 10(18):eadl6082, 03 May 2024
Cited by: 1 article | PMID: 38701207 | PMCID: PMC11068011
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TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2.
Ahmed N, Preisinger C, Wilhelm T, Huber M
Cells, 13(9):747, 25 Apr 2024
Cited by: 0 articles | PMID: 38727283 | PMCID: PMC11082977
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VCP Inhibition Augments NLRP3 Inflammasome Activation.
Sharma A, Dhavale DD, Kotzbauer PT, Weihl CC
Inflammation, 47(5):1868-1883, 02 Apr 2024
Cited by: 0 articles | PMID: 38563877
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Large-Scale Whole-Genome Analysis of HTLV-1-Associated Myelopathy Identified Hereditary Spastic Paraplegias.
Takao N, Yagishita N, Araya N, Aratani S, Yamauchi J, Takahashi K, Kunitomo Y, Sato T, Nakamori M, Kawai Y, Omae Y, Tokunaga K, Matsuda F, Mitsuhashi S, Yamano Y
Neurol Genet, 10(1):e200108, 29 Jan 2024
Cited by: 0 articles | PMID: 38716326 | PMCID: PMC11073877
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Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.
Tsioras K, Smith KC, Edassery SL, Garjani M, Li Y, Williams C, McKenna ED, Guo W, Wilen AP, Hark TJ, Marklund SL, Ostrow LW, Gilthorpe JD, Ichida JK, Kalb RG, Savas JN, Kiskinis E
Cell Rep, 42(10):113160, 29 Sep 2023
Cited by: 4 articles | PMID: 37776851 | PMCID: PMC10785776
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An autosomal-dominant childhood-onset disorder associated with pathogenic variants in VCP.
Mah-Som AY, Daw J, Huynh D, Wu M, Creekmore BC, Burns W, Skinner SA, Holla ØL, Smeland MF, Planes M, Uguen K, Redon S, Bierhals T, Scholz T, Denecke J, Mensah MA, Sczakiel HL, Tichy H, Verheyen S, [...] Shinawi MS
Am J Hum Genet, 110(11):1959-1975, 25 Oct 2023
Cited by: 3 articles | PMID: 37883978 | PMCID: PMC10645565
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The endolysosomal pathway and ALS/FTD.
Todd TW, Shao W, Zhang YJ, Petrucelli L
Trends Neurosci, 46(12):1025-1041, 10 Oct 2023
Cited by: 5 articles | PMID: 37827960
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Skeletal muscle cell protein dysregulation highlights the pathogenesis mechanism of myopathy-associated p97/VCP R155H mutations.
Luzzi A, Wang F, Li S, Iacovino M, Chou TF
Front Neurol, 14:1211635, 03 Aug 2023
Cited by: 0 articles | PMID: 37602234 | PMCID: PMC10435852
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Autophagy and neurodegeneration: Unraveling the role of C9ORF72 in the regulation of autophagy and its relationship to ALS-FTD pathology.
Diab R, Pilotto F, Saxena S
Front Cell Neurosci, 17:1086895, 16 Mar 2023
Cited by: 10 articles | PMID: 37006471 | PMCID: PMC10060823
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Dysregulated proteostasis network in neuronal diseases.
Tseng CS, Chao YW, Liu YH, Huang YS, Chao HW
Front Cell Dev Biol, 11:1075215, 24 Feb 2023
Cited by: 5 articles | PMID: 36910151 | PMCID: PMC9998692
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Paget's disease: a review of the epidemiology, etiology, genetics, and treatment.
Banaganapalli B, Fallatah I, Alsubhi F, Shetty PJ, Awan Z, Elango R, Shaik NA
Front Genet, 14:1131182, 26 Apr 2023
Cited by: 4 articles | PMID: 37180975 | PMCID: PMC10169728
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Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis.
Yu Q, Li C, Niu Q, Wang J, Che Z, Lei K, Ren H, Ma B, Ren Y, Luo P, Fan Z, Zhang H, Liu Z, Tipoe GL, Xiao J
Acta Pharm Sin B, 13(6):2628-2644, 10 Mar 2023
Cited by: 2 articles | PMID: 37425048 | PMCID: PMC10326296
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Porcine Reproductive and Respiratory Syndrome Virus nsp5 Induces Incomplete Autophagy by Impairing the Interaction of STX17 and SNAP29.
Zhou Y, Li Y, Tao R, Li J, Fang L, Xiao S
Microbiol Spectr, e0438622, 23 Feb 2023
Cited by: 4 articles | PMID: 36815765 | PMCID: PMC10101144
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Southern rice black-streaked dwarf virus induces incomplete autophagy for persistence in gut epithelial cells of its vector insect.
Zhang L, Liu W, Wu N, Wang H, Zhang Z, Liu Y, Wang X
PLoS Pathog, 19(1):e1011134, 27 Jan 2023
Cited by: 4 articles | PMID: 36706154 | PMCID: PMC9907856
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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system.
Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS
Nat Commun, 14(1):560, 02 Feb 2023
Cited by: 21 articles | PMID: 36732333 | PMCID: PMC9894937
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PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.
Bai Y, Yu G, Zhou HM, Amarasinghe O, Zhou Y, Zhu P, Li Q, Zhang L, Nguele Meke F, Miao Y, Chapman E, Tao WA, Zhang ZY
Autophagy, 19(5):1562-1581, 07 Nov 2022
Cited by: 5 articles | PMID: 36300783 | PMCID: PMC10240998
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EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly.
Tang X, Wei W, Snowball JM, Nakayasu ES, Bell SM, Ansong C, Lin X, Whitsett JA
iScience, 26(1):105667, 24 Nov 2022
Cited by: 1 article | PMID: 36624844 | PMCID: PMC9823123
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Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration.
Mahali S, Martinez R, King M, Verbeck A, Harari O, Benitez BA, Horie K, Sato C, Temple S, Karch CM
Transl Psychiatry, 12(1):508, 10 Dec 2022
Cited by: 7 articles | PMID: 36494352 | PMCID: PMC9734180
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