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Search life-sciences literature (45,103,589 articles, preprints and more)

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1-22 of 22 results

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Ligand-based virtual-screening identified a novel CFTR ligand which improves the defective cell surface expression of misfolded ABC transporters.
Taniguchi S, Berenger F, Doi Y, Mimura A, Yamanishi Y, Okiyoneda T
Front Pharmacol, 15:1370676, 11 Apr 2024
Cited by: 0 articles | PMID: 38666024 | PMCID: PMC11043560
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The cellular pathways that maintain the quality control and transport of diverse potassium channels.
Nguyen NH, Brodsky JL
Biochim Biophys Acta Gene Regul Mech, 1866(1):194908, 10 Jan 2023
Cited by: 3 articles | PMID: 36638864 | PMCID: PMC9908860
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Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations.
Li JV, Ng CA, Cheng D, Zhou Z, Yao M, Guo Y, Yu ZY, Ramaswamy Y, Ju LA, Kuchel PW, Feneley MP, Fatkin D, Cox CD
Commun Biol, 4(1):1038, 06 Sep 2021
Cited by: 14 articles | PMID: 34489534 | PMCID: PMC8421374
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Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels.
Kanner SA, Jain A, Colecraft HM
Front Physiol, 9:397, 19 Apr 2018
Cited by: 19 articles | PMID: 29725305 | PMCID: PMC5917007
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Visualizing Mutation-Specific Differences in the Trafficking-Deficient Phenotype of Kv11.1 Proteins Linked to Long QT Syndrome Type 2.
Hall AR, Anderson CL, Smith JL, Mirshahi T, Elayi CS, January CT, Delisle BP
Front Physiol, 9:584, 23 May 2018
Cited by: 2 articles | PMID: 29875689 | PMCID: PMC5974211
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Functional Invalidation of Putative Sudden Infant Death Syndrome-Associated Variants in the KCNH2-Encoded Kv11.1 Channel.
Smith JL, Tester DJ, Hall AR, Burgess DE, Hsu CC, Elayi SC, Anderson CL, January CT, Luo JZ, Hartzel DN, Mirshahi UL, Murray MF, Mirshahi T, Ackerman MJ, Delisle BP
Circ Arrhythm Electrophysiol, 11(5):e005859, 01 May 2018
Cited by: 2 articles | PMID: 29752375
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Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells.
Yu D, Lv L, Fang L, Zhang B, Wang J, Zhan G, Zhao L, Zhao X, Li B
PLoS One, 12(8):e0181823, 01 Aug 2017
Cited by: 9 articles | PMID: 28763460 | PMCID: PMC5538702
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Potassium channels in the heart: structure, function and regulation.
Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V
J Physiol, 595(7):2209-2228, 13 Nov 2016
Cited by: 51 articles | PMID: 27861921
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Electrophysiological Characteristics of the LQT2 Syndrome Mutation KCNH2-G572S and Regulation by Accessory Protein KCNE2.
Liu L, Tian J, Lu C, Chen X, Fu Y, Xu B, Zhu C, Sun Y, Zhang Y, Zhao Y, Li Y
Front Physiol, 7:650, 27 Dec 2016
Cited by: 8 articles | PMID: 28082916 | PMCID: PMC5187237
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A rare schizophrenia risk variant of CACNA1I disrupts Ca_V3.3 channel activity.
Andrade A, Hope J, Allen A, Yorgan V, Lipscombe D, Pan JQ
Sci Rep, 6:34233, 19 Oct 2016
Cited by: 37 articles | PMID: 27756899 | PMCID: PMC5069464
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Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms.
Spence S, Deurinck M, Ju H, Traebert M, McLean L, Marlowe J, Emotte C, Tritto E, Tseng M, Shultz M, Friedrichs GS
Toxicol Sci, 153(1):39-54, 02 Jun 2016
Cited by: 14 articles | PMID: 27255383
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Molecular pathogenesis of long QT syndrome type 2.
Smith JL, Anderson CL, Burgess DE, Elayi CS, January CT, Delisle BP
J Arrhythm, 32(5):373-380, 22 Jan 2016
Cited by: 57 articles | PMID: 27761161 | PMCID: PMC5063260
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Mouse ERG K(+) channel clones reveal differences in protein trafficking and function.
Lin EC, Moungey BM, Lim E, Concannon SP, Anderson CL, Kyle JW, Makielski JC, Balijepalli SY, January CT
J Am Heart Assoc, 3(6):e001491, 11 Dec 2014
Cited by: 1 article | PMID: 25497881 | PMCID: PMC4338741
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Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening.
Calcaterra NE, Hoeppner DJ, Wei H, Jaffe AE, Maher BJ, Barrow JC
Sci Rep, 6:19976, 16 Feb 2016
Cited by: 12 articles | PMID: 26879421 | PMCID: PMC4754628
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Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects.
Zhang KP, Yang BF, Li BX
Acta Pharmacol Sin, 35(12):1473-1484, 24 Nov 2014
Cited by: 18 articles | PMID: 25418379 | PMCID: PMC4261120
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MiR-17-5p impairs trafficking of H-ERG K+ channel protein by targeting multiple er stress-related chaperones during chronic oxidative stress.
Wang Q, Hu W, Lei M, Wang Y, Yan B, Liu J, Zhang R, Jin Y
PLoS One, 8(12):e84984, 30 Dec 2013
Cited by: 6 articles | PMID: 24386440 | PMCID: PMC3875566
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Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.
Bellin M, Casini S, Davis RP, D'Aniello C, Haas J, Ward-van Oostwaard D, Tertoolen LG, Jung CB, Elliott DA, Welling A, Laugwitz KL, Moretti A, Mummery CL
EMBO J, 32(24):3161-3175, 08 Nov 2013
Cited by: 136 articles | PMID: 24213244 | PMCID: PMC3981141
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Mutant hERG channel traffic jam. Focus on "Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum".
Ayon RJ, Fernandez RA, Yuan JX
Am J Physiol Cell Physiol, 305(9):C916-8, 28 Aug 2013
Cited by: 3 articles | PMID: 23986200
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Mechanistic basis for type 2 long QT syndrome caused by KCNH2 mutations that disrupt conserved arginine residues in the voltage sensor.
McBride CM, Smith AM, Smith JL, Reloj AR, Velasco EJ, Powell J, Elayi CS, Bartos DC, Burgess DE, Delisle BP
J Membr Biol, 246(5):355-364, 02 Apr 2013
Cited by: 10 articles | PMID: 23546015 | PMCID: PMC3706098
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Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum.
Smith JL, Reloj AR, Nataraj PS, Bartos DC, Schroder EA, Moss AJ, Ohno S, Horie M, Anderson CL, January CT, Delisle BP
Am J Physiol Cell Physiol, 305(9):C919-30, 17 Jul 2013
Cited by: 24 articles | PMID: 23864605 | PMCID: PMC4042535
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Mechanisms underlying the protein-kinase mediated regulation of the HERG potassium channel synthesis.
Krishnan Y, Li Y, Zheng R, Kanda V, McDonald TV
Biochim Biophys Acta, 1823(8):1273-1284, 18 May 2012
Cited by: 8 articles | PMID: 22613764 | PMCID: PMC3398701
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Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma.
Okubo J, Takita J, Chen Y, Oki K, Nishimura R, Kato M, Sanada M, Hiwatari M, Hayashi Y, Igarashi T, Ogawa S
Oncogene, 31(44):4667-4676, 16 Jan 2012
Cited by: 32 articles | PMID: 22249260
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1-22 of 22 results

Search life-sciences literature (45,103,589 articles, preprints and more)

Search results

Ligand-based virtual-screening identified a novel CFTR ligand which improves the defective cell surface expression of misfolded ABC transporters.

The cellular pathways that maintain the quality control and transport of diverse potassium channels.

Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations.

Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels.

Visualizing Mutation-Specific Differences in the Trafficking-Deficient Phenotype of Kv11.1 Proteins Linked to Long QT Syndrome Type 2.

Functional Invalidation of Putative Sudden Infant Death Syndrome-Associated Variants in the KCNH2-Encoded Kv11.1 Channel.

Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells.

Potassium channels in the heart: structure, function and regulation.

Electrophysiological Characteristics of the LQT2 Syndrome Mutation KCNH2-G572S and Regulation by Accessory Protein KCNE2.

A rare schizophrenia risk variant of CACNA1I disrupts Ca_V3.3 channel activity.

Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms.

Molecular pathogenesis of long QT syndrome type 2.

Mouse ERG K(+) channel clones reveal differences in protein trafficking and function.

Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening.

Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects.

MiR-17-5p impairs trafficking of H-ERG K+ channel protein by targeting multiple er stress-related chaperones during chronic oxidative stress.

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.

Mutant hERG channel traffic jam. Focus on "Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum".

Mechanistic basis for type 2 long QT syndrome caused by KCNH2 mutations that disrupt conserved arginine residues in the voltage sensor.

Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum.

Mechanisms underlying the protein-kinase mediated regulation of the HERG potassium channel synthesis.

Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma.

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