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Search life-sciences literature (45,105,671 articles, preprints and more)

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How is Excitotoxicity Being Modelled in iPSC-Derived Neurons?
Cheng JL, Cook AL, Talbot J, Perry S
Neurotox Res, 42(5):43, 15 Oct 2024
Cited by: 0 articles | PMID: 39405005 | PMCID: PMC11480214
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Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects.
de Calbiac H, Renault S, Haouy G, Jung V, Roger K, Zhou Q, Campanari ML, Chentout L, Demy DL, Marian A, Goudin N, Edbauer D, Guerrera C, Ciura S, Kabashi E
Autophagy, 20(10):2164-2185, 24 Sep 2024
Cited by: 0 articles | PMID: 39316747 | PMCID: PMC11423671
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Expression Changes of miRNAs in Humans and Animal Models of Amyotrophic Lateral Sclerosis and Their Potential Application for Clinical Diagnosis.
Wang R, Chen L, Zhang Y, Sun B, Liang M
Life (Basel), 14(9):1125, 06 Sep 2024
Cited by: 0 articles | PMID: 39337908 | PMCID: PMC11433357
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Biomolecular condensates and disease pathogenesis.
Ruan K, Bai G, Fang Y, Li D, Li T, Liu X, Lu B, Lu Q, Songyang Z, Sun S, Wang Z, Zhang X, Zhou W, Zhang H
Sci China Life Sci, 67(9):1792-1832, 17 Jul 2024
Cited by: 0 articles | PMID: 39037698
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Updates on Disease Mechanisms and Therapeutics for Amyotrophic Lateral Sclerosis.
Nguyen L
Cells, 13(11):888, 21 May 2024
Cited by: 0 articles | PMID: 38891021 | PMCID: PMC11172142
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Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model.
Kojak N, Kuno J, Fittipaldi KE, Khan A, Wenger D, Glasser M, Donnianni RA, Tang Y, Zhang J, Huling K, Ally R, Mujica AO, Turner T, Magardino G, Huang PY, Kerk SY, Droguett G, Prissette M, Rojas J, [...] Kajimura D
Nucleic Acids Res, 52(10):5732-5755, 01 Jun 2024
Cited by: 0 articles | PMID: 38597682
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Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia.
Funes S, Jung J, Gadd DH, Mosqueda M, Zhong J, Shankaracharya, Unger M, Stallworth K, Cameron D, Rotunno MS, Dawes P, Fowler-Magaw M, Keagle PJ, McDonough JA, Boopathy S, Sena-Esteves M, Nickerson JA, Lutz C, Skarnes WC, [...] Bosco DA
Nat Commun, 15(1):2497, 20 Mar 2024
Cited by: 0 articles | PMID: 38509062 | PMCID: PMC10954694
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PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons.
Milioto C, Carcolé M, Giblin A, Coneys R, Attrebi O, Ahmed M, Harris SS, Lee BI, Yang M, Ellingford RA, Nirujogi RS, Biggs D, Salomonsson S, Zanovello M, de Oliveira P, Katona E, Glaria I, Mikheenko A, Geary B, [...] Isaacs AM
Nat Neurosci, 27(4):643-655, 29 Feb 2024
Cited by: 3 articles | PMID: 38424324 | PMCID: PMC11001582
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Role of C9orf72 hexanucleotide repeat expansions in ALS/FTD pathogenesis.
Geng Y, Cai Q
Front Mol Neurosci, 17:1322720, 22 Jan 2024
Cited by: 2 articles | PMID: 38318532 | PMCID: PMC10838790
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Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice.
Kahriman A, Bouley J, Tuncali I, Dogan EO, Pereira M, Luu T, Bosco DA, Jaber S, Peters OM, Brown RH, Henninger N
Brain, 146(12):5139-5152, 01 Dec 2023
Cited by: 3 articles | PMID: 37527465 | PMCID: PMC11046056
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Microglia and Astrocytes in Amyotrophic Lateral Sclerosis: Disease-Associated States, Pathological Roles, and Therapeutic Potential.
You J, Youssef MMM, Santos JR, Lee J, Park J
Biology (Basel), 12(10):1307, 03 Oct 2023
Cited by: 5 articles | PMID: 37887017 | PMCID: PMC10603852
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A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons.
Beckers J, Tharkeshwar AK, Fumagalli L, Contardo M, Van Schoor E, Fazal R, Thal DR, Chandran S, Mancuso R, Van Den Bosch L, Van Damme P
Acta Neuropathol Commun, 11(1):151, 18 Sep 2023
Cited by: 3 articles | PMID: 37723585 | PMCID: PMC10506245
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Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptide repeat proteins in vivo.
Cabrera GT, Meijboom KE, Abdallah A, Tran H, Foster Z, Weiss A, Wightman N, Stock R, Gendron T, Gruntman A, Giampetruzzi A, Petrucelli L, Brown RH, Mueller C
Gene Ther, 31(3-4):105-118, 26 Sep 2023
Cited by: 2 articles | PMID: 37752346
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Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges.
Zhu L, Li S, Li XJ, Yin P
Transl Neurodegener, 12(1):46, 20 Sep 2023
Cited by: 4 articles | PMID: 37730668 | PMCID: PMC10510301
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Advances in the Structure of GGGGCC Repeat RNA Sequence and Its Interaction with Small Molecules and Protein Partners.
Liu X, Zhao X, He J, Wang S, Shen X, Liu Q, Wang S
Molecules, 28(15):5801, 01 Aug 2023
Cited by: 2 articles | PMID: 37570771 | PMCID: PMC10420822
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Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags.
Morón-Oset J, Fischer LK, Carcolé M, Giblin A, Zhang P, Isaacs AM, Grönke S, Partridge L
Life Sci Alliance, 6(9):e202201739, 12 Jun 2023
Cited by: 4 articles | PMID: 37308278 | PMCID: PMC10262077
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Evidence of Metabolic Dysfunction in Amyotrophic Lateral Sclerosis (ALS) Patients and Animal Models.
Maksimovic K, Youssef M, You J, Sung HK, Park J
Biomolecules, 13(5):863, 19 May 2023
Cited by: 5 articles | PMID: 37238732 | PMCID: PMC10216611
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C9ORF72 knockdown triggers FTD-like symptoms and cell pathology in mice.
Lopez-Herdoiza MB, Bauché S, Wilmet B, Le Duigou C, Roussel D, Frah M, Béal J, Devely G, Boluda S, Frick P, Bouteiller D, Dussaud S, Guillabert P, Dalle C, Dumont M, Camuzat A, Saracino D, Barbier M, Bruneteau G, [...] Latouche M
Front Cell Neurosci, 17:1155929, 17 Apr 2023
Cited by: 3 articles | PMID: 37138765 | PMCID: PMC10149765
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Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation.
Mead RJ, Shan N, Reiser HJ, Marshall F, Shaw PJ
Nat Rev Drug Discov, 22(3):185-212, 21 Dec 2022
Cited by: 95 articles | PMID: 36543887 | PMCID: PMC9768794
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Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease.
Jambeau M, Meyer KD, Hruska-Plochan M, Tabet R, Lee CZ, Ray-Soni A, Aguilar C, Savage K, Mishra N, Cavegn N, Borter P, Lin CC, Jansen-West KR, Jiang J, Freyermuth F, Li N, De Rossi P, Pérez-Berlanga M, Jiang X, [...] Lagier-Tourenne C
Proc Natl Acad Sci U S A, 119(49):e2123487119, 01 Dec 2022
Cited by: 2 articles | PMID: 36454749 | PMCID: PMC9894253
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C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.
Zheng W, Wang K, Wu Y, Yan G, Zhang C, Li Z, Wang L, Chen S
Theranostics, 12(17):7289-7306, 17 Oct 2022
Cited by: 5 articles | PMID: 36438488 | PMCID: PMC9691347
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CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.
Meijboom KE, Abdallah A, Fordham NP, Nagase H, Rodriguez T, Kraus C, Gendron TF, Krishnan G, Esanov R, Andrade NS, Rybin MJ, Ramic M, Stephens ZD, Edraki A, Blackwood MT, Kahriman A, Henninger N, Kocher JA, Benatar M, [...] Mueller C
Nat Commun, 13(1):6286, 21 Oct 2022
Cited by: 25 articles | PMID: 36271076 | PMCID: PMC9587249
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Antisense Oligonucleotides for the Study and Treatment of ALS.
Boros BD, Schoch KM, Kreple CJ, Miller TM
Neurotherapeutics, 19(4):1145-1158, 02 Jun 2022
Cited by: 32 articles | PMID: 35653060 | PMCID: PMC9587169
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Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.
Burley S, Beccano-Kelly DA, Talbot K, Llana OC, Wade-Martins R
Sci Rep, 12(1):7378, 05 May 2022
Cited by: 8 articles | PMID: 35513421 | PMCID: PMC9072315
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MicroRNA expression in animal models of amyotrophic lateral sclerosis and potential therapeutic approaches.
Martinez B, Peplow PV
Neural Regen Res, 17(4):728-740, 01 Apr 2022
Cited by: 9 articles | PMID: 34472458 | PMCID: PMC8530133
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1-25 of 173 results

1 2 3 Next ...

Search life-sciences literature (45,105,671 articles, preprints and more)

Search results

How is Excitotoxicity Being Modelled in iPSC-Derived Neurons?

Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects.

Expression Changes of miRNAs in Humans and Animal Models of Amyotrophic Lateral Sclerosis and Their Potential Application for Clinical Diagnosis.

Biomolecular condensates and disease pathogenesis.

Updates on Disease Mechanisms and Therapeutics for Amyotrophic Lateral Sclerosis.

Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model.

Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia.

PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons.

Role of C9orf72 hexanucleotide repeat expansions in ALS/FTD pathogenesis.

Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice.

Microglia and Astrocytes in Amyotrophic Lateral Sclerosis: Disease-Associated States, Pathological Roles, and Therapeutic Potential.

A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons.

Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptide repeat proteins in vivo.

Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges.

Advances in the Structure of GGGGCC Repeat RNA Sequence and Its Interaction with Small Molecules and Protein Partners.

Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags.

Evidence of Metabolic Dysfunction in Amyotrophic Lateral Sclerosis (ALS) Patients and Animal Models.

C9ORF72 knockdown triggers FTD-like symptoms and cell pathology in mice.

Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation.

Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease.

C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.

CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.

Antisense Oligonucleotides for the Study and Treatment of ALS.

Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.

MicroRNA expression in animal models of amyotrophic lateral sclerosis and potential therapeutic approaches.

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