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Search life-sciences literature (45,103,589 articles, preprints and more)

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Napabucasin Inhibits Proliferation and Migration of Glioblastoma Cells (U87) by Regulating JAK2/STAT3 Signaling Pathway.
Ünlü İ, Özdemir İ, Tuncer MC
Medicina (Kaunas), 60(10):1715, 19 Oct 2024
Cited by: 0 articles | PMID: 39459502 | PMCID: PMC11509140
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Lipid metabolism dynamics in cancer stem cells: potential targets for cancers.
Du J, Qin H
Front Pharmacol, 15:1367981, 27 Jun 2024
Cited by: 1 article | PMID: 38994204 | PMCID: PMC11236562
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Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression.
Sánchez-Ramírez D, Mendoza-Rodríguez MG, Alemán OR, Candanedo-González FA, Rodríguez-Sosa M, Montesinos-Montesinos JJ, Salcedo M, Brito-Toledo I, Vaca-Paniagua F, Terrazas LI
World J Gastrointest Oncol, 16(5):1705-1724, 01 May 2024
Cited by: 0 articles | PMID: 38764833 | PMCID: PMC11099434
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The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone.
Shao Z, Wang H, Ren H, Sun Y, Chen X
Molecules, 28(15):5678, 27 Jul 2023
Cited by: 5 articles | PMID: 37570646 | PMCID: PMC10420168
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An Isoxazoloquinone Derivative Inhibits Tumor Growth by Targeting STAT3 and Triggering Its Ubiquitin-Dependent Degradation.
Xie Y, Zhu S, Chen L, Liu H, Peng T, Ming Z, Zou Z, Hu X, Luo W, Peng K, Nie Y, Luo T, Ma D, Liu S, Luo Z
Cancers (Basel), 15(9):2424, 23 Apr 2023
Cited by: 1 article | PMID: 37173892 | PMCID: PMC10177496
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The Molecular Biology of Prostate Cancer Stem Cells: From the Past to the Future.
Zhou Y, Li T, Jia M, Dai R, Wang R
Int J Mol Sci, 24(8):7482, 19 Apr 2023
Cited by: 2 articles | PMID: 37108647 | PMCID: PMC10140972
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The cancer stemness inhibitor napabucasin suppresses small cell lung cancer growth through SOX2 expression.
Li JM, Hsu PC, Kuan FC, Shi CS, Yang CT
Am J Cancer Res, 12(10):4637-4651, 15 Oct 2022
Cited by: 4 articles | PMID: 36381330 | PMCID: PMC9641396
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Novel mechanism of napabucasin, a naturally derived furanonaphthoquinone: apoptosis and autophagy induction in lung cancer cells through direct targeting on Akt/mTOR proteins.
Petsri K, Thongsom S, Racha S, Chamni S, Jindapol S, Kaekratoke N, Zou H, Chanvorachote P
BMC Complement Med Ther, 22(1):250, 30 Sep 2022
Cited by: 4 articles | PMID: 36180880 | PMCID: PMC9524025
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Heparanase regulates EMT and cancer stem cell properties in prostate tumors.
Masola V, Franchi M, Zaza G, Atsina FM, Gambaro G, Onisto M
Front Oncol, 12:918419, 27 Jul 2022
Cited by: 2 articles | PMID: 35965510 | PMCID: PMC9363836
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Endothelial nitric oxide synthase (eNOS)-NO signaling axis functions to promote the growth of prostate cancer stem-like cells.
Gao W, Wang Y, Yu S, Wang Z, Ma T, Chan AM, Chiu PK, Ng CF, Wu D, Chan FL
Stem Cell Res Ther, 13(1):188, 07 May 2022
Cited by: 6 articles | PMID: 35526071 | PMCID: PMC9080127
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Upregulation of miR-216a-5p by Lentinan Targeted Inhibition of JAK2/STAT3 Signaling Pathway to Reduce Lung Adenocarcinoma Cell Stemness, Promote Apoptosis, and Slow Down the Lung Adenocarcinoma Mechanisms.
Chen Q, Zheng Y, Chen X, Ge P, Wang P, Wu B
Front Oncol, 11:778096, 25 Nov 2021
Cited by: 5 articles | PMID: 34900727 | PMCID: PMC8656221
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Interplay of Epidermal Growth Factor Receptor and Signal Transducer and Activator of Transcription 3 in Prostate Cancer: Beyond Androgen Receptor Transactivation.
Lin SR, Yeh HL, Liu YN
Cancers (Basel), 13(14):3452, 09 Jul 2021
Cited by: 4 articles | PMID: 34298665 | PMCID: PMC8307975
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Phase I study of napabucasin in combination with FOLFIRI + bevacizumab in Japanese patients with metastatic colorectal cancer.
Taniguchi H, Masuishi T, Kawazoe A, Muro K, Kadowaki S, Bando H, Iino S, Kageyama R, Yoshino T
Int J Clin Oncol, 26(11):2017-2024, 21 Jul 2021
Cited by: 8 articles | PMID: 34291369 | PMCID: PMC8520863
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Combinatorial Strategies to Target Molecular and Signaling Pathways to Disarm Cancer Stem Cells.
Catara G, Colanzi A, Spano D
Front Oncol, 11:689131, 26 Jul 2021
Cited by: 3 articles | PMID: 34381714 | PMCID: PMC8352560
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Napabucasin Induces Mouse Bone Loss by Impairing Bone Formation via STAT3.
Huang X, Jin A, Wang X, Gao X, Xu H, Chung M, Dai Q, Yang Y, Jiang L
Front Cell Dev Biol, 9:648866, 18 Mar 2021
Cited by: 3 articles | PMID: 33816498 | PMCID: PMC8014090
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Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours.
Gampala S, Shah F, Zhang C, Rhodes SD, Babb O, Grimard M, Wireman RS, Rad E, Calver B, Bai RY, Staedtke V, Hulsey EL, Saadatzadeh MR, Pollok KE, Tong Y, Smith AE, Clapp DW, Tee AR, Kelley MR, Fishel ML
Br J Cancer, 124(9):1566-1580, 03 Mar 2021
Cited by: 12 articles | PMID: 33658640 | PMCID: PMC8076291
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Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models.
Caston RA, Shah F, Starcher CL, Wireman R, Babb O, Grimard M, McGeown J, Armstrong L, Tong Y, Pili R, Rupert J, Zimmers TA, Elmi AN, Pollok KE, Motea EA, Kelley MR, Fishel ML
J Cell Mol Med, 25(2):784-800, 03 Dec 2020
Cited by: 9 articles | PMID: 33274592 | PMCID: PMC7812272
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Bone Marrow-Derived Myofibroblasts Promote Gastric Cancer Metastasis by Activating TGF-β1 and IL-6/STAT3 Signalling Loop.
Wang J, Li Q, Cheng X, Zhang B, Lin J, Tang Y, Li F, Yang CS, Wang TC, Tu S
Onco Targets Ther, 13:10567-10580, 16 Oct 2020
Cited by: 5 articles | PMID: 33116635 | PMCID: PMC7585554
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The synergistic anticancer effects of ReoT3D, CPT-11, and BBI608 on murine colorectal cancer cells.
Babaei A, Soleimanjahi H, Soleimani M, Arefian E
Daru, 28(2):555-565, 15 Aug 2020
Cited by: 3 articles | PMID: 32803686 | PMCID: PMC7704878
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The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication.
Pádua D, Figueira P, Ribeiro I, Almeida R, Mesquita P
Front Cell Dev Biol, 8:442, 18 Jun 2020
Cited by: 19 articles | PMID: 32626705 | PMCID: PMC7314965
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Targeting the Tumor Core: Hypoxia-Responsive Nanoparticles for the Delivery of Chemotherapy to Pancreatic Tumors.
Confeld MI, Mamnoon B, Feng L, Jensen-Smith H, Ray P, Froberg J, Kim J, Hollingsworth MA, Quadir M, Choi Y, Mallik S
Mol Pharm, 17(8):2849-2863, 22 Jul 2020
Cited by: 19 articles | PMID: 32521162 | PMCID: PMC8114572
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Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells.
Li H, Feng Z, He ML
Theranostics, 10(16):7053-7069, 30 May 2020
Cited by: 84 articles | PMID: 32641978 | PMCID: PMC7330842
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Phase 1 study of napabucasin, a cancer stemness inhibitor, in patients with advanced solid tumors.
Kawazoe A, Kuboki Y, Bando H, Fukuoka S, Kojima T, Naito Y, Iino S, Yodo Y, Doi T, Shitara K, Yoshino T
Cancer Chemother Pharmacol, 85(5):855-862, 31 Mar 2020
Cited by: 17 articles | PMID: 32236642 | PMCID: PMC7188713
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LncRNA NCK1-AS1 Promotes Cancer Cell Proliferation and Increase Cell Stemness in Urinary Bladder Cancer Patients by Downregulating miR-143.
Qiao Z, Dai H, Zhang Y, Li Q, Zhao M, Yue T
Cancer Manag Res, 12:1661-1668, 06 Mar 2020
Cited by: 11 articles | PMID: 32184669 | PMCID: PMC7064288
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NQO1 is a determinant for cellular sensitivity to anti-tumor agent Napabucasin.
Guo G, Gao Z, Tong M, Zhan D, Wang G, Wang Y, Qin J
Am J Cancer Res, 10(5):1442-1454, 01 May 2020
Cited by: 4 articles | PMID: 32509390 | PMCID: PMC7269777
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