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Search life-sciences literature (45,103,589 articles, preprints and more)

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Know your molecule: pharmacological characterization of drug candidates to enhance efficacy and reduce late-stage attrition.
Kenakin T
Nat Rev Drug Discov, 23(8):626-644, 18 Jun 2024
Cited by: 0 articles | PMID: 38890494
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Improving ADMET Prediction Accuracy for Candidate Drugs: Factors to Consider in QSPR Modeling Approaches.
Chen M, Yang J, Tang C, Lu X, Wei Z, Liu Y, Yu P, Li H
Curr Top Med Chem, 24(3):222-242, 01 Jan 2024
Cited by: 1 article | PMID: 38083894
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Pro-phagocytic function and structural basis of GPR84 signaling.
Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, Chen S, Jenkins L, Marsango S, Li X, Liu G, Milligan G, Feng M, Fan H, Gong W, Zhang C
Nat Commun, 14(1):5706, 14 Sep 2023
Cited by: 4 articles | PMID: 37709767 | PMCID: PMC10502086
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Exploring the kinetic selectivity of drugs targeting the β₁ -adrenoceptor.
Sykes DA, Jiménez-Rosés M, Reilly J, Fairhurst RA, Charlton SJ, Veprintsev DB
Pharmacol Res Perspect, 10(4):e00978, 01 Aug 2022
Cited by: 1 article | PMID: 35762357 | PMCID: PMC9237807
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Mapping CAR T-Cell Design Space Using Agent-Based Models.
Prybutok AN, Yu JS, Leonard JN, Bagheri N
Front Mol Biosci, 9:849363, 12 Jul 2022
Cited by: 9 articles | PMID: 35903149 | PMCID: PMC9315201
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Interaction With the Lipid Membrane Influences Fentanyl Pharmacology.
Sutcliffe KJ, Corey RA, Alhosan N, Cavallo D, Groom S, Santiago M, Bailey C, Charlton SJ, Sessions RB, Henderson G, Kelly E
Adv Drug Alcohol Res, 2:adar.2022.10280, 01 Mar 2022
Cited by: 10 articles | PMID: 35909438 | PMCID: PMC7613138
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Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design.
Róg T, Girych M, Bunker A
Pharmaceuticals (Basel), 14(10):1062, 19 Oct 2021
Cited by: 11 articles | PMID: 34681286 | PMCID: PMC8537670
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Ligand binding at the protein-lipid interface: strategic considerations for drug design.
Payandeh J, Volgraf M
Nat Rev Drug Discov, 20(9):710-722, 13 Jul 2021
Cited by: 36 articles | PMID: 34257432
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Membrane-Facilitated Receptor Access and Binding Mechanisms of Long-Acting β2-Adrenergic Receptor Agonists.
Szlenk CT, Gc JB, Natesan S
Mol Pharmacol, 100(4):406-427, 01 Aug 2021
Cited by: 4 articles | PMID: 34334369 | PMCID: PMC8626642
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A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.
Mai QN, Shenoy P, Quach T, Retamal JS, Gondin AB, Yeatman HR, Aurelio L, Conner JW, Poole DP, Canals M, Nowell CJ, Graham B, Davis TP, Briddon SJ, Hill SJ, Porter CJH, Bunnett NW, Halls ML, Veldhuis NA
J Biol Chem, 296:100345, 28 Jan 2021
Cited by: 7 articles | PMID: 33515548 | PMCID: PMC7949131
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A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding.
White CW, Kilpatrick LE, Pfleger KDG, Hill SJ
iScience, 24(1):102011, 30 Dec 2020
Cited by: 2 articles | PMID: 33490919 | PMCID: PMC7809502
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α₂-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling.
Kalwat MA, Huang Z, Binns DD, McGlynn K, Cobb MH
Front Cell Dev Biol, 8:576396, 15 Oct 2020
Cited by: 3 articles | PMID: 33178692 | PMCID: PMC7593622
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Application of fluorescence correlation spectroscopy to study substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2.
Horsey AJ, Briggs DA, Holliday ND, Briddon SJ, Kerr ID
Biochim Biophys Acta Biomembr, 1862(6):183218, 11 Feb 2020
Cited by: 9 articles | PMID: 32057756 | PMCID: PMC7156912
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Fentanyl depression of respiration: Comparison with heroin and morphine.
Hill R, Santhakumar R, Dewey W, Kelly E, Henderson G
Br J Pharmacol, 177(2):254-266, 23 Dec 2019
Cited by: 77 articles | PMID: 31499594 | PMCID: PMC6989952
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Binding kinetics of ligands acting at GPCRs.
Sykes DA, Stoddart LA, Kilpatrick LE, Hill SJ
Mol Cell Endocrinol, 485:9-19, 08 Feb 2019
Cited by: 37 articles | PMID: 30738950 | PMCID: PMC6406023
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Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors?
Szlenk CT, Gc JB, Natesan S
Mol Pharmacol, 96(5):527-541, 08 Apr 2019
Cited by: 27 articles | PMID: 30967440 | PMCID: PMC6776015
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Signalling in response to sub-picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity.
Civciristov S, Halls ML
Br J Pharmacol, 176(14):2382-2401, 05 Apr 2019
Cited by: 6 articles | PMID: 30801691 | PMCID: PMC6592860
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Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations.
Civciristov S, Ellisdon AM, Suderman R, Pon CK, Evans BA, Kleifeld O, Charlton SJ, Hlavacek WS, Canals M, Halls ML
Sci Signal, 11(551):eaan1188, 09 Oct 2018
Cited by: 22 articles | PMID: 30301787 | PMCID: PMC7416780
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Link between a high k _on for drug binding and a fast clinical action: to be or not to be?
Vauquelin G
Medchemcomm, 9(9):1426-1438, 16 Aug 2018
Cited by: 6 articles | PMID: 30288218 | PMCID: PMC6151451
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