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Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PL^pro and M^pro proteases, and nsp14 guanine N7-methyltransferase.
Zmudzinski M, Rut W, Olech K, Granda J, Giurg M, Burda-Grabowska M, Kaleta R, Zgarbova M, Kasprzyk R, Zhang L, Sun X, Lv Z, Nayak D, Kesik-Brodacka M, Olsen SK, Weber J, Hilgenfeld R, Jemielity J, Drag M
Sci Rep, 13(1):9161, 06 Jun 2023
Cited by: 13 articles | PMID: 37280236 | PMCID: PMC10242237
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Identification of potential Indonesian marine invertebrate bioactive compounds as TMPRSS2 and SARS-CoV-2 Omicron spike protein inhibitors through computational screening.
Rizka Nurcahyaningtyas H, Irene A, Tri Wibowo J, Yunovilsa Putra M, Yanuar A
Arab J Chem, 16(9):104984, 16 May 2023
Cited by: 0 articles | PMID: 37234226 | PMCID: PMC10186851
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In Silico Approach for the Evaluation of the Potential Antiviral Activity of Extra Virgin Olive Oil (EVOO) Bioactive Constituents Oleuropein and Oleocanthal on Spike Therapeutic Drug Target of SARS-CoV-2.
Geromichalou EG, Geromichalos GD
Molecules, 27(21):7572, 04 Nov 2022
Cited by: 3 articles | PMID: 36364398 | PMCID: PMC9655607
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Immunogenetic Predisposition to SARS-CoV-2 Infection.
Lehmann C, Loeffler-Wirth H, Balz V, Enczmann J, Landgraf R, Lakowa N, Gruenewald T, Fischer JC, Doxiadis I
Biology (Basel), 12(1):37, 25 Dec 2022
Cited by: 7 articles | PMID: 36671730 | PMCID: PMC9855425
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In silico drug repurposing for coronavirus (COVID-19): screening known HCV drugs against the SARS-CoV-2 spike protein bound to angiotensin-converting enzyme 2 (ACE2) (6M0J).
Kalamatianos KG
Mol Divers, 27(3):1087-1099, 23 Jun 2022
Cited by: 4 articles | PMID: 35739375 | PMCID: PMC9223260
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The Roles and Pathogenesis Mechanisms of a Number of Micronutrients in the Prevention and/or Treatment of Chronic Hepatitis, COVID-19 and Type-2 Diabetes Mellitus.
Sumaily KM
Nutrients, 14(13):2632, 24 Jun 2022
Cited by: 3 articles | PMID: 35807813 | PMCID: PMC9268086
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Andrographolide induces anti-SARS-CoV-2 response through host-directed mechanism: an in silico study.
Das BS, Das NC, Swain SS, Mukherjee S, Bhattacharya D
Future Virol, 01 Jun 2022
Cited by: 5 articles | PMID: 35812188 | PMCID: PMC9254363
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Study of protease-mediated processes initiating viral infection and cell-cell viral spreading of SARS-CoV-2.
Thaingtamtanha T, Baeurle SA
J Mol Model, 28(8):224, 19 Jul 2022
Cited by: 3 articles | PMID: 35854129 | PMCID: PMC9296015
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Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2.
Uma Reddy B, Routhu NK, Kumar A
Microb Pathog, 168:105512, 02 Apr 2022
Cited by: 5 articles | PMID: 35381324 | PMCID: PMC8976571
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Can polyoxometalates (POMs) prevent of coronavirus 2019-nCoV cell entry? Interaction of POMs with TMPRSS2 and spike receptor domain complexed with ACE2 (ACE2-RBD): Virtual screening approaches.
Shahabadi N, Mahdavi M, Zendehcheshm S
Inform Med Unlocked, 29:100902, 05 Mar 2022
Cited by: 3 articles | PMID: 35284620 | PMCID: PMC8896857
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Mutational scanning of spike RBD protein for enhanced ACE2 affinity emerging Southeast Asia in the late transmission phase.
Kodchakorn K, Chokepaichitkool T, Kongtawelert P
Sci Rep, 12(1):5896, 07 Apr 2022
Cited by: 2 articles | PMID: 35393512 | PMCID: PMC8989122
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In silico prediction of natural compounds as potential multi-target inhibitors of structural proteins of SARS-CoV-2.
Rani J, Bhargav A, Khan FI, Ramachandran S, Lai D, Bajpai U
J Biomol Struct Dyn, 40(22):12118-12134, 06 Sep 2021
Cited by: 7 articles | PMID: 34486935 | PMCID: PMC8425474
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Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells.
Ostrov DA, Bluhm AP, Li D, Khan JQ, Rohamare M, Rajamanickam K, K Bhanumathy K, Lew J, Falzarano D, Vizeacoumar FJ, Wilson JA, Mottinelli M, Kanumuri SRR, Sharma A, McCurdy CR, Norris MH
Pathogens, 10(11):1514, 20 Nov 2021
Cited by: 9 articles | PMID: 34832669 | PMCID: PMC8620039
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COVID-19, Cation Dysmetabolism, Sialic Acid, CD147, ACE2, Viroporins, Hepcidin and Ferroptosis: A Possible Unifying Hypothesis.
Cavezzi A, Menicagli R, Troiani E, Corrao S
F1000Res, 11:102, 27 Jan 2022
Cited by: 13 articles | PMID: 35340277 | PMCID: PMC8921693
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Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection.
Dampalla CS, Zheng J, Perera KD, Wong LR, Meyerholz DK, Nguyen HN, Kashipathy MM, Battaile KP, Lovell S, Kim Y, Perlman S, Groutas WC, Chang KO
Proc Natl Acad Sci U S A, 118(29):e2101555118, 01 Jul 2021
Cited by: 50 articles | PMID: 34210738 | PMCID: PMC8307543
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Metabologenomics approach to the discovery of novel compounds from Streptomyces sp. GMR22 as anti-SARS-CoV-2 drugs.
Melinda YN, Widada J, Wahyuningsih TD, Febriansah R, Damayanti E, Mustofa M
Heliyon, 7(11):e08308, 02 Nov 2021
Cited by: 3 articles | PMID: 34746476 | PMCID: PMC8560767
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Drug Repurposing to Identify Nilotinib as a Potential SARS-CoV-2 Main Protease Inhibitor: Insights from a Computational and In Vitro Study.
Banerjee S, Yadav S, Banerjee S, Fakayode SO, Parvathareddy J, Reichard W, Surendranathan S, Mahmud F, Whatcott R, Thammathong J, Meibohm B, Miller DD, Jonsson CB, Dubey KD
J Chem Inf Model, 61(11):5469-5483, 20 Oct 2021
Cited by: 18 articles | PMID: 34666487
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Computational Simulations Identified Marine-Derived Natural Bioactive Compounds as Replication Inhibitors of SARS-CoV-2.
Kumar V, Parate S, Yoon S, Lee G, Lee KW
Front Microbiol, 12:647295, 21 Apr 2021
Cited by: 17 articles | PMID: 33967984 | PMCID: PMC8097174
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Repurposing of FDA-approved drugs against active site and potential allosteric drug-binding sites of COVID-19 main protease.
Yuce M, Cicek E, Inan T, Dag AB, Kurkcuoglu O, Sungur FA
Proteins, 89(11):1425-1441, 05 Jul 2021
Cited by: 24 articles | PMID: 34169568 | PMCID: PMC8441840
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Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.
Gunst JD, Staerke NB, Pahus MH, Kristensen LH, Bodilsen J, Lohse N, Dalgaard LS, Brønnum D, Fröbert O, Hønge B, Johansen IS, Monrad I, Erikstrup C, Rosendal R, Vilstrup E, Mariager T, Bove DG, Offersen R, Shakar S, [...] Søgaard OS
EClinicalMedicine, 35:100849, 22 Apr 2021
Cited by: 115 articles | PMID: 33903855 | PMCID: PMC8060682
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Potential 3-chymotrypsin-like cysteine protease cleavage sites in the coronavirus polyproteins pp1a and pp1ab and their possible relevance to COVID-19 vaccine and drug development.
Yan S, Wu G
FASEB J, 35(5):e21573, 01 May 2021
Cited by: 18 articles | PMID: 33913206 | PMCID: PMC8206714
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Repurposing drugs during the COVID-19 pandemic and beyond.
Ravi S, Jadhav S, Vaidya A, Ghooi R
Pharm Pat Anal, 10(1):9-12, 15 Jan 2021
Cited by: 0 articles | PMID: 33445955 | PMCID: PMC7814678
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Targeting the viral-entry facilitators of SARS-CoV-2 as a therapeutic strategy in COVID-19.
Muralidar S, Gopal G, Visaga Ambi S
J Med Virol, 93(9):5260-5276, 03 May 2021
Cited by: 21 articles | PMID: 33851732 | PMCID: PMC8251167
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Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of SARS-Coronavirus.
Hartini Y, Saputra B, Wahono B, Auw Z, Indayani F, Adelya L, Namba G, Hariono M
Results Chem, 3:100087, 25 Dec 2020
Cited by: 5 articles | PMID: 33520632 | PMCID: PMC7832947
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Molecular mechanisms of the novel coronavirus SARS-CoV-2 and potential anti-COVID19 pharmacological targets since the outbreak of the pandemic.
Vlachakis D, Papakonstantinou E, Mitsis T, Pierouli K, Diakou I, Chrousos G, Bacopoulou F
Food Chem Toxicol, 146:111805, 08 Oct 2020
Cited by: 19 articles | PMID: 33038452 | PMCID: PMC7543766
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1-25 of 31 results

1 2

Search life-sciences literature (45,103,589 articles, preprints and more)

Search results

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PL^pro and M^pro proteases, and nsp14 guanine N7-methyltransferase.

Identification of potential Indonesian marine invertebrate bioactive compounds as TMPRSS2 and SARS-CoV-2 Omicron spike protein inhibitors through computational screening.

In Silico Approach for the Evaluation of the Potential Antiviral Activity of Extra Virgin Olive Oil (EVOO) Bioactive Constituents Oleuropein and Oleocanthal on Spike Therapeutic Drug Target of SARS-CoV-2.

Immunogenetic Predisposition to SARS-CoV-2 Infection.

In silico drug repurposing for coronavirus (COVID-19): screening known HCV drugs against the SARS-CoV-2 spike protein bound to angiotensin-converting enzyme 2 (ACE2) (6M0J).

The Roles and Pathogenesis Mechanisms of a Number of Micronutrients in the Prevention and/or Treatment of Chronic Hepatitis, COVID-19 and Type-2 Diabetes Mellitus.

Andrographolide induces anti-SARS-CoV-2 response through host-directed mechanism: an in silico study.

Study of protease-mediated processes initiating viral infection and cell-cell viral spreading of SARS-CoV-2.

Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2.

Can polyoxometalates (POMs) prevent of coronavirus 2019-nCoV cell entry? Interaction of POMs with TMPRSS2 and spike receptor domain complexed with ACE2 (ACE2-RBD): Virtual screening approaches.

Mutational scanning of spike RBD protein for enhanced ACE2 affinity emerging Southeast Asia in the late transmission phase.

In silico prediction of natural compounds as potential multi-target inhibitors of structural proteins of SARS-CoV-2.

Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells.

COVID-19, Cation Dysmetabolism, Sialic Acid, CD147, ACE2, Viroporins, Hepcidin and Ferroptosis: A Possible Unifying Hypothesis.

Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection.

Metabologenomics approach to the discovery of novel compounds from Streptomyces sp. GMR22 as anti-SARS-CoV-2 drugs.

Drug Repurposing to Identify Nilotinib as a Potential SARS-CoV-2 Main Protease Inhibitor: Insights from a Computational and In Vitro Study.

Computational Simulations Identified Marine-Derived Natural Bioactive Compounds as Replication Inhibitors of SARS-CoV-2.

Repurposing of FDA-approved drugs against active site and potential allosteric drug-binding sites of COVID-19 main protease.

Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.

Potential 3-chymotrypsin-like cysteine protease cleavage sites in the coronavirus polyproteins pp1a and pp1ab and their possible relevance to COVID-19 vaccine and drug development.

Repurposing drugs during the COVID-19 pandemic and beyond.

Targeting the viral-entry facilitators of SARS-CoV-2 as a therapeutic strategy in COVID-19.

Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of SARS-Coronavirus.

Molecular mechanisms of the novel coronavirus SARS-CoV-2 and potential anti-COVID19 pharmacological targets since the outbreak of the pandemic.

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