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Search life-sciences literature (45,103,589 articles, preprints and more)

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Deubiquitinases in Ovarian Cancer: Role in Drug Resistance and Tumor Aggressiveness.
Beretta GL, Costantino M, Mirra L, Pettinari P, Perego P
Int J Biol Sci, 20(13):5208-5222, 23 Sep 2024
Cited by: 0 articles | PMID: 39430244 | PMCID: PMC11489175
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The ubiquitin-proteasome system in the tumor immune microenvironment: a key force in combination therapy.
Wang Y, Li S, Wang W
Front Immunol, 15:1436174, 09 Sep 2024
Cited by: 0 articles | PMID: 39315102 | PMCID: PMC11416925
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5,7,4'-Trimethoxyflavone triggers cancer cell PD-L1 ubiquitin-proteasome degradation and facilitates antitumor immunity by targeting HRD1.
Xia J, Xu M, Hu H, Zhang Q, Yu D, Cai M, Geng X, Zhang H, Zhang Y, Guo M, Lu D, Xu H, Li L, Zhang X, Wang Q, Liu S, Zhang W
MedComm (2020), 5(7):e611, 27 Jun 2024
Cited by: 0 articles | PMID: 38938284 | PMCID: PMC11208742
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Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets.
Hong Z, Liu F, Zhang Z
Exp Hematol Oncol, 13(1):91, 30 Aug 2024
Cited by: 0 articles | PMID: 39223632 | PMCID: PMC11367865
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Demethylzeylasteral induces PD-L1 ubiquitin-proteasome degradation and promotes antitumor immunity <i>via</i> targeting USP22.
Zhang Y, Huang Y, Yu D, Xu M, Hu H, Zhang Q, Cai M, Geng X, Zhang H, Xia J, Guo M, Lu D, Xu H, Li L, Zhang X, Wang Q, Liu S, Zhang W
Acta Pharm Sin B, 14(10):4312-4328, 08 Aug 2024
Cited by: 0 articles | PMID: 39525573
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Emerging therapeutic frontiers in cancer: insights into posttranslational modifications of PD-1/PD-L1 and regulatory pathways.
Wang R, He S, Long J, Wang Y, Jiang X, Chen M, Wang J
Exp Hematol Oncol, 13(1):46, 23 Apr 2024
Cited by: 2 articles | PMID: 38654302 | PMCID: PMC11040904
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The Deubiquitinase USP22-Stabilized COL17A1 Promotes Lung Adenocarcinoma Progression.
Chen G, Du D, Wang H, Li H
Clin Respir J, 18(8):e13824, 01 Aug 2024
Cited by: 0 articles | PMID: 39143031 | PMCID: PMC11324370
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Regulation of post-translational modification of PD-L1 and associated opportunities for novel small-molecule therapeutics.
Tang J, Liu H, Li J, Zhang Y, Yao S, Yang K, You Z, Qiao X, Song Y
Future Med Chem, 16(15):1583-1599, 01 Jul 2024
Cited by: 0 articles | PMID: 38949857
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Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches.
Liu F, Chen J, Li K, Li H, Zhu Y, Zhai Y, Lu B, Fan Y, Liu Z, Chen X, Jia X, Dong Z, Liu K
Mol Cancer, 23(1):148, 25 Jul 2024
Cited by: 0 articles | PMID: 39048965 | PMCID: PMC11270804
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Targeting the PD-L1 cytoplasmic domain and its regulatory pathways to enhance cancer immunotherapy.
Chai F, Li P, Liu X, Zhou Z, Ren H
J Mol Cell Biol, 15(11):mjad070, 01 Apr 2024
Cited by: 1 article | PMID: 37993416 | PMCID: PMC11193063
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PTMs of PD-1/PD-L1 and PROTACs application for improving cancer immunotherapy.
Ren X, Wang L, Liu L, Liu J
Front Immunol, 15:1392546, 04 Apr 2024
Cited by: 1 article | PMID: 38638430 | PMCID: PMC11024247
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USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression.
Kowald L, Roedig J, Karlowitz R, Wagner K, Smith S, Juretschke T, Beli P, Müller S, van Wijk SJL
Cell Death Discov, 10(1):128, 11 Mar 2024
Cited by: 0 articles | PMID: 38467608 | PMCID: PMC10928094
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EZH2 Inhibition Enhances PD-L1 Protein Stability Through USP22-Mediated Deubiquitination in Colorectal Cancer.
Huang J, Yin Q, Wang Y, Zhou X, Guo Y, Tang Y, Cheng R, Yu X, Zhang J, Huang C, Huang Z, Zhang J, Guo Z, Huo X, Sun Y, Li Y, Wang H, Yang J, Xue L
Adv Sci (Weinh), 11(23):e2308045, 22 Mar 2024
Cited by: 5 articles | PMID: 38520088 | PMCID: PMC11187912
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From immune checkpoints to therapies: understanding immune checkpoint regulation and the influence of natural products and traditional medicine on immune checkpoint and immunotherapy in lung cancer.
Zhou Y, Wang F, Li G, Xu J, Zhang J, Gullen E, Yang J, Wang J
Front Immunol, 15:1340307, 15 Feb 2024
Cited by: 0 articles | PMID: 38426097 | PMCID: PMC10902058
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Ubiquitination of Immune System and Cancer Therapy.
Du Y, Zhang H, Hu H
Adv Exp Med Biol, 1466:35-45, 01 Jan 2024
Cited by: 0 articles | PMID: 39546134
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USP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activity.
Kuang X, Salinger A, Benavides F, Muller WJ, Dent SYR, Koutelou E
PLoS One, 19(1):e0290837, 18 Jan 2024
Cited by: 0 articles | PMID: 38236941 | PMCID: PMC10796002
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Programmed Death Ligand 1 Regulatory Crosstalk with Ubiquitination and Deubiquitination: Implications in Cancer Immunotherapy.
Kim SB, Hwang S, Cha JY, Lee HJ
Int J Mol Sci, 25(5):2939, 03 Mar 2024
Cited by: 0 articles | PMID: 38474186 | PMCID: PMC10932311
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Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1.
Ren W, Xu Z, Chang Y, Ju F, Wu H, Liang Z, Zhao M, Wang N, Lin Y, Xu C, Chen S, Rao Y, Lin C, Yang J, Liu P, Zhang J, Huang C, Xia N
Nat Commun, 15(1):9, 02 Jan 2024
Cited by: 4 articles | PMID: 38167274 | PMCID: PMC10761827
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Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375/PRKDC Axis and PD-L1 phosphorylation.
Miao Z, Li J, Wang Y, Shi M, Gu X, Zhang X, Wei F, Tang X, Zheng L, Xing Y
Mol Cancer, 22(1):205, 13 Dec 2023
Cited by: 14 articles | PMID: 38093288 | PMCID: PMC10718020
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Ubiquitin-specific protease 22 promotes tumorigenesis and progression by an FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma.
Ye Q, Zhou W, Xu S, Que Q, Zhan Q, Zhang L, Zheng S, Ling S, Xu X
MedComm (2020), 4(6):e439, 01 Dec 2023
Cited by: 3 articles | PMID: 38045832 | PMCID: PMC10691294
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Deubiquitinases in cancer.
Dewson G, Eichhorn PJA, Komander D
Nat Rev Cancer, 23(12):842-862, 07 Nov 2023
Cited by: 35 articles | PMID: 37935888
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Inhibition of USP7 upregulates USP22 and activates its downstream cancer-related signaling pathways in human cancer cells.
Zhang K, Sun T, Li W, Guo Y, Li A, Hsieh M, Wang J, Wu J, Arvanitis L, Raz DJ
Cell Commun Signal, 21(1):319, 09 Nov 2023
Cited by: 0 articles | PMID: 37946202 | PMCID: PMC10634000
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Challenges Coexist with Opportunities: Spatial Heterogeneity Expression of PD-L1 in Cancer Therapy.
Wang Y, Zhou Y, Yang L, Lei L, He B, Cao J, Gao H
Adv Sci (Weinh), 11(1):e2303175, 07 Nov 2023
Cited by: 10 articles | PMID: 37934012 | PMCID: PMC10767451
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Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells.
Mu N, Wang Y, Li X, Du Z, Wu Y, Su M, Wang Y, Sun X, Su L, Liu X
Cell Death Dis, 14(9):645, 30 Sep 2023
Cited by: 3 articles | PMID: 37777549 | PMCID: PMC10542755
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Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application.
Gao H, Yin J, Ji C, Yu X, Xue J, Guan X, Zhang S, Liu X, Xing F
J Exp Clin Cancer Res, 42(1):225, 01 Sep 2023
Cited by: 16 articles | PMID: 37658402 | PMCID: PMC10472646
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