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Search life-sciences literature (45,105,671 articles, preprints and more)

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Stereoselective formation of a functionalized dipeptide isostere by zinc carbenoid-mediated chain extension.
Lin W, Theberge CR, Henderson TJ, Zercher CK, Jasinski J, Butcher RJ
J Org Chem, 74(2):645-651, 01 Jan 2009
Cited by: 3 articles | PMID: 19055379 | PMCID: PMC2680025
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Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure.
Hanessian S, Therrien E, van Otterlo WA, Bayrakdarian M, Nilsson I, Fjellström O, Xue Y
Bioorg Med Chem Lett, 16(4):1032-1036, 15 Nov 2005
Cited by: 5 articles | PMID: 16290930
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Design, synthesis and biological activity of a targeted library of potential tryptase inhibitors.
García M, del Rio X, Silvestre S, Rubiralta M, Lozoya E, Segarra V, Fernández D, Miralpeix M, Aparici M, Diez A
Org Biomol Chem, 2(11):1633-1642, 12 May 2004
Cited by: 5 articles | PMID: 15162216
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Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors.
Huang W, Naughton MA, Yang H, Su T, Dam S, Wong PW, Arfsten A, Edwards S, Sinha U, Hollenbach S, Scarborough RM, Zhu BY
Bioorg Med Chem Lett, 13(4):723-728, 01 Feb 2003
Cited by: 4 articles | PMID: 12639567
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Synthesis and activity of 5'-uridinyl dipeptide analogues mimicking the amino terminal peptide chain of nucleoside antibiotic mureidomycin A.
Howard NI, Bugg TD
Bioorg Med Chem, 11(14):3083-3099, 01 Jul 2003
Cited by: 32 articles | PMID: 12818671
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Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates.
Cui JJ, Araldi GL, Reiner JE, Reddy KM, Kemp SJ, Ho JZ, Siev DV, Mamedova L, Gibson TS, Gaudette JA, Minami NK, Anderson SM, Bradbury AE, Nolan TG, Semple JE
Bioorg Med Chem Lett, 12(20):2925-2930, 01 Oct 2002
Cited by: 8 articles | PMID: 12270176
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Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates.
Reiner JE, Siev DV, Araldi GL, Cui JJ, Ho JZ, Reddy KM, Mamedova L, Vu PH, Lee KS, Minami NK, Gibson TS, Anderson SM, Bradbury AE, Nolan TG, Semple JE
Bioorg Med Chem Lett, 12(8):1203-1208, 01 Apr 2002
Cited by: 11 articles | PMID: 11934589
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Novel, potent non-covalent thrombin inhibitors incorporating p(3)-lactam scaffolds.
Ho JZ, Gibson TS, Semple JE
Bioorg Med Chem Lett, 12(5):743-748, 01 Mar 2002
Cited by: 8 articles | PMID: 11858993
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Protease inhibitors - Part 3. Synthesis of non-basic thrombin inhibitors incorporating pyridinium-sulfanilylguanidine moieties at the P1 site.
Scozzafava A, Briganti F, Supuran CT
Eur J Med Chem, 34(11):939-952, 01 Nov 1999
Cited by: 4 articles | PMID: 10889318
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In vitro and in vivo properties of bicyclic lactam inhibitors: a novel class of low molecular weight peptidomimetic thrombin inhibitors.
Leblond L, Grouix B, Boudreau C, Yang Q, Siddiqui MA, Winocour PD
Thromb Res, 100(3):195-209, 01 Nov 2000
Cited by: 3 articles | PMID: 11108907
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Potent and selective thrombin inhibitors featuring hydrophobic, basic P3-P4-aminoalkyllactam moieties.
Semple JE, Rowley DC, Owens TD, Minami NK, Uong TH, Brunck TK
Bioorg Med Chem Lett, 8(24):3525-3530, 01 Dec 1998
Cited by: 7 articles | PMID: 9934465
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Determination of enantiomers in a synthetic argininal peptide using capillary zone electrophoresis and high-performance liquid chromatography.
Dan N, Ganesan R, Flood KG, Tsai D, Reif VD
J Chromatogr A, 891(1):115-127, 01 Sep 2000
Cited by: 4 articles | PMID: 10999631
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Protease inhibitors. Part 2. Weakly basic thrombin inhibitors incorporating sulfonyl-aminoguanidine moieties as S1 anchoring groups: synthesis and structure-activity correlations.
Clare BW, Scozzafava A, Briganti F, Iorga B, Supuran CT
J Enzyme Inhib, 15(3):235-264, 01 Jan 2000
Cited by: 3 articles | PMID: 10811030
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Guanylpiperidine peptidomimetics: potent and selective bis-cation inhibitors of factor Xa.
Tamura SY, Levy OE, Uong TH, Reiner JE, Goldman EA, Ho JZ, Cohen CR, Bergum PW, Nutt RF, Brunck TK, Semple JE
Bioorg Med Chem Lett, 10(8):745-749, 01 Apr 2000
Cited by: 4 articles | PMID: 10782677
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L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor.
Sanderson PE, Cutrona KJ, Dorsey BD, Dyer DL, McDonough CM, Naylor-Olsen AM, Chen IW, Chen Z, Cook JJ, Gardell SJ, Krueger JA, Lewis SD, Lin JH, Lucas BJ, Lyle EA, Lynch JJ, Stranieri MT, Vastag K, Shafer JA, Vacca JP
Bioorg Med Chem Lett, 8(7):817-822, 01 Apr 1998
Cited by: 32 articles | PMID: 9871547
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Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor.
Oh YS, Yun M, Hwang SY, Hong S, Shin Y, Lee K, Yoon KH, Yoo YJ, Kim DS, Lee SH, Lee YH, Park HD, Lee CH, Lee SK, Kim S
Bioorg Med Chem Lett, 8(6):631-634, 01 Mar 1998
Cited by: 18 articles | PMID: 9871573
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Asymmetric synthesis of novel quaternary alpha-hydroxy-delta-lactam dipeptide surrogates.
Minami NK, Reiner JE, Semple JE
Bioorg Med Chem Lett, 9(17):2625-2628, 01 Sep 1999
Cited by: 7 articles | PMID: 10498222
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Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: structures based on the (D)-Arg-Gly-Arg tripeptide sequence.
Marlowe CK, Sinha U, Gunn AC, Scarborough RM
Bioorg Med Chem Lett, 10(1):13-16, 01 Jan 2000
Cited by: 6 articles | PMID: 10636232
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Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy.
Zhang M, Bailey DL, Bastian JA, Briggs SL, Chirgadze NY, Clawson DK, Denney ML, Gifford-Moore DS, Harper RW, Johnson LM, Klimkowski VJ, Kohn TJ, Lin HS, McCowan JR, Richett ME, Sall DJ, Smith AJ, Smith GF, Snyder DW, [...] Yan SC
Bioorg Med Chem Lett, 9(5):775-780, 01 Mar 1999
Cited by: 6 articles | PMID: 10201846
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Protease inhibitors: Part 4. Synthesis of weakly basic thrombin inhibitors incorporating pyridinium-sulfanilylaminoguanidine moieties.
Supuran CT, Briganti F, Scozzafava A, Ilies MA
J Enzyme Inhib, 15(4):335-356, 01 Jan 2000
Cited by: 2 articles | PMID: 10995066
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Design and construction of novel thrombin inhibitors featuring P3-P4 quaternary lactam dipeptide surrogates.
Semple JE
Bioorg Med Chem Lett, 8(18):2501-2506, 01 Sep 1998
Cited by: 6 articles | PMID: 9873569
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Novel benzo-fused lactam scaffolds as factor Xa inhibitors.
Tamura SY, Goldman EA, Bergum PW, Semple JE
Bioorg Med Chem Lett, 9(17):2573-2578, 01 Sep 1999
Cited by: 6 articles | PMID: 10498211
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Investigation of the S3 site of thrombin: design, synthesis and biological activity of 4-substituted 3-amino-2-pyridones incorporating P1-argininals.
Reiner JE, Lim-Wilby MS, Brunck TK, Ha-Uong T, Goldman EA, Abelman MA, Nutt RF, Semple JE, Tamura SY
Bioorg Med Chem Lett, 9(6):895-900, 01 Mar 1999
Cited by: 10 articles | PMID: 10206557
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Alkoxide-catalyzed ring-opening of a novel homosaccharin derivative: synthesis of potent, selective P3-lactam thrombin inhibitors containing P4-o-alkoxycarbonylbenzylsulfonamide residues.
Owens TD, Semple JE
Bioorg Med Chem Lett, 8(24):3683-3688, 01 Dec 1998
Cited by: 6 articles | PMID: 9934495
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New thrombin inhibitors in cardiovascular disease.
Ripka WC
Curr Opin Chem Biol, 1(2):242-253, 01 Aug 1997
Cited by: 15 articles | PMID: 9667850
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