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Tafa1 Gene Detail
Summary
  • Symbol
    Tafa1
  • Name
    TAFA chemokine like family member 1
  • Synonyms
    C630007B19Rik, Fam19a1, Tafa-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443695
    NCBI Gene: 320265
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:96090135-96634159 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 44.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    14242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443695
 protein coding gene Chr6:96090135-96634169 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031069
 protein coding gene Chr6:97924630-98474153 (+)
A/J MGP_AJ_G0031038
 protein coding gene Chr6:94211360-94751296 (+)
AKR/J MGP_AKRJ_G0030969
 protein coding gene Chr6:96802645-97357961 (+)
BALB/cJ MGP_BALBcJ_G0031049
 protein coding gene Chr6:94155334-94703968 (+)
C3H/HeJ MGP_C3HHeJ_G0030658
 protein coding gene Chr6:87059693-87630299 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031508
 protein coding gene Chr6:100363783-100961220 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028673
 protein coding gene Chr6:92107589-92630022 (+)
CAST/EiJ MGP_CASTEiJ_G0030156
 protein coding gene Chr6:97004313-97556756 (+)
CBA/J MGP_CBAJ_G0030735
 protein coding gene Chr6:104181051-104777082 (+)
DBA/2J MGP_DBA2J_G0030888
 protein coding gene Chr6:93358520-93888891 (+)
FVB/NJ MGP_FVBNJ_G0030842
 protein coding gene Chr6:92545332-93079709 (+)
LP/J MGP_LPJ_G0030968
 protein coding gene Chr6:97929545-98496383 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030876
 protein coding gene Chr6:108160245-108744250 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031535
 protein coding gene Chr6:96669483-97233202 (+)
PWK/PhJ MGP_PWKPhJ_G0029872
 protein coding gene Chr6:92364607-92897988 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029700
 protein coding gene Chr6:95601082-96145285 (+)
WSB/EiJ MGP_WSBEiJ_G0030240
 protein coding gene Chr6:97139198-97699570 (+)



Homology
more
  • Human Ortholog
    TAFA1, TAFA chemokine like family member 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAFA1, TAFA chemokine like family member 1
  • Synonyms
    FAM19A1, TAFA-1
  • Links
    NCBI Gene ID: 407738
    neXtProt AC: NX_Q7Z5A9
    UniProt: Q7Z5A9

  • Chr Location
    3p14.1; chr3:67991544-68545621 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit sex-dependent alterations in food intake patterns, locomotor activity, anxiety-like behavior, dopamine turnover, and sensitivity to pain induced by heat or electric shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    872
  • Tissues
    75
  • cDNA Data
    4
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059187 Ensembl Gene Model | MGI Sequence Detail 544025 C57BL/6J ±  kb
    transcript ENSMUST00000122120 Ensembl | MGI Sequence Detail 3252 Not Applicable  
    polypeptide ENSMUSP00000113152 Ensembl | MGI Sequence Detail 133 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 4
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:6276241
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory