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Tafa3 Gene Detail
Summary
  • Symbol
    Tafa3
  • Name
    TAFA chemokine like family member 3
  • Synonyms
    7530404M11Rik, Fam19a3, Sam3, Tafa-3, Tafa3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3046463
    NCBI Gene: 329731
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:104674721-104686854 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.84 cM, cytoband F2.2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    407 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3046463
 protein coding gene Chr3:104674721-104689156 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027708
 protein coding gene Chr3:106090752-106105173 (-)
A/J MGP_AJ_G0027668
 protein coding gene Chr3:102709301-102723770 (-)
AKR/J MGP_AKRJ_G0027633
 protein coding gene Chr3:105235592-105249945 (-)
BALB/cJ MGP_BALBcJ_G0027680
 protein coding gene Chr3:102494416-102508774 (-)
C3H/HeJ MGP_C3HHeJ_G0027410
 protein coding gene Chr3:105617009-105631444 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028124
 protein coding gene Chr3:110054784-110069146 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025464
 protein coding gene Chr3:98819706-98834007 (-)
CAST/EiJ MGP_CASTEiJ_G0026866
 protein coding gene Chr3:104732168-104746627 (-)
CBA/J MGP_CBAJ_G0027385
 protein coding gene Chr3:113799266-113816124 (-)
DBA/2J MGP_DBA2J_G0027527
 protein coding gene Chr3:101963269-101977619 (-)
FVB/NJ MGP_FVBNJ_G0027495
 protein coding gene Chr3:99884574-99898996 (-)
LP/J MGP_LPJ_G0027634
 protein coding gene Chr3:107469756-107484843 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0028179
 protein coding gene Chr3:104795911-104810243 (-)
PWK/PhJ MGP_PWKPhJ_G0026592
 protein coding gene Chr3:101742695-101753711 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026413
 protein coding gene Chr3:102832593-102847002 (-)
WSB/EiJ MGP_WSBEiJ_G0026946
 protein coding gene Chr3:105373110-105388509 (-)



Homology
more
  • Human Ortholog
    TAFA3, TAFA chemokine like family member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAFA3, TAFA chemokine like family member 3
  • Synonyms
    FAM19A3, TAFA-3
  • Links
    NCBI Gene ID: 284467
    neXtProt AC: NX_Q7Z5A8
    UniProt: Q7Z5A8

  • Chr Location
    1p13.2; chr1:112718905-112727235 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tafa3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show impaired responses to social novelty, defects in social communication, and increased repetitive behavior. Although only male homozygotes show increased anxiety and repetitive marble-burying behavior, both sexes show increased levels of self-grooming.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 329731 NCBI Gene Model | MGI Sequence Detail 12134 C57BL/6J ±  kb
    transcript NM_183224 RefSeq | MGI Sequence Detail 4317 C57BL/6  
    polypeptide Q7TPG6 UniProt | EBI | MGI Sequence Detail 132 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:6276245
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:80645 Carninci P, et al., High-efficiency full-length cDNA cloning. Methods Enzymol. 1999;303:19-44
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory