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Hepatic tuberculosis

MedGen UID:
11944
•Concept ID:
C0041313
•
Disease or Syndrome
Synonyms: Hepatic Tuberculoses; Hepatic Tuberculosis; Tuberculoses, Hepatic; Tuberculosis, Hepatic
SNOMED CT: Tuberculosis of liver (186273003)
 
Monarch Initiative: MONDO:0005787

Definition

Infection of the liver with species of mycobacterium, most often mycobacterium tuberculosis. It is characterized by localized small tuberculous miliary lesions or tumor-like mass (tuberculoma), and abnormalities in liver function tests. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatic tuberculosis

Professional guidelines

PubMed

Diagnosis and treatment of congenital tuberculosis: a systematic review of 92 cases.
Li C, Liu L, Tao Y
Orphanet J Rare Dis 2019 Jun 10;14(1):131. doi: 10.1186/s13023-019-1101-x. PMID: 31182120Free PMC Article
Tuberculosis and liver disease: management issues.
Sonika U, Kar P
Trop Gastroenterol 2012 Apr-Jun;33(2):102-6. doi: 10.7869/tg.2012.25. PMID: 23025055
Treatment of congenital tuberculosis.
Patel S, DeSantis ER
Am J Health Syst Pharm 2008 Nov 1;65(21):2027-31. doi: 10.2146/ajhp080054. PMID: 18945861

Recent clinical studies

Etiology

Hepatic tuberculosis masquerading as malignancy.
Kale A, Patil PS, Chhanchure U, Deodhar K, Kulkarni S, Mehta S, Tandon S
Hepatol Int 2022 Apr;16(2):463-472. Epub 2021 Oct 23 doi: 10.1007/s12072-021-10257-9. PMID: 34687434
Extrapulmonary involvement in pediatric tuberculosis.
Kritsaneepaiboon S, Andres MM, Tatco VR, Lim CCQ, Concepcion NDP
Pediatr Radiol 2017 Sep;47(10):1249-1259. Epub 2017 Aug 29 doi: 10.1007/s00247-017-3867-0. PMID: 29052770
Tuberculosis and liver disease: management issues.
Sonika U, Kar P
Trop Gastroenterol 2012 Apr-Jun;33(2):102-6. doi: 10.7869/tg.2012.25. PMID: 23025055
Abdominal tuberculosis: imaging features.
Pereira JM, Madureira AJ, Vieira A, Ramos I
Eur J Radiol 2005 Aug;55(2):173-80. doi: 10.1016/j.ejrad.2005.04.015. PMID: 15908155
Hepatobiliary tuberculosis.
Alvarez SZ, Carpio R
Dig Dis Sci 1983 Mar;28(3):193-200. doi: 10.1007/BF01295113. PMID: 6825541

Diagnosis

Diagnosis and treatment of congenital tuberculosis: a systematic review of 92 cases.
Li C, Liu L, Tao Y
Orphanet J Rare Dis 2019 Jun 10;14(1):131. doi: 10.1186/s13023-019-1101-x. PMID: 31182120Free PMC Article
Extrapulmonary involvement in pediatric tuberculosis.
Kritsaneepaiboon S, Andres MM, Tatco VR, Lim CCQ, Concepcion NDP
Pediatr Radiol 2017 Sep;47(10):1249-1259. Epub 2017 Aug 29 doi: 10.1007/s00247-017-3867-0. PMID: 29052770
Imaging Spectrum of Extrathoracic Tuberculosis.
Raut AA, Naphade PS, Ramakantan R
Radiol Clin North Am 2016 May;54(3):475-501. Epub 2016 Mar 4 doi: 10.1016/j.rcl.2015.12.013. PMID: 27153784
Hepatobiliary tuberculosis.
Bandyopadhyay S, Maity PK
J Assoc Physicians India 2013 Jun;61(6):404-7. PMID: 24640207
Hepatobiliary tuberculosis.
Alvarez SZ
J Gastroenterol Hepatol 1998 Aug;13(8):833-9. doi: 10.1111/j.1440-1746.1998.tb00743.x. PMID: 9736180

Therapy

Hepatic tuberculosis masquerading as malignancy.
Kale A, Patil PS, Chhanchure U, Deodhar K, Kulkarni S, Mehta S, Tandon S
Hepatol Int 2022 Apr;16(2):463-472. Epub 2021 Oct 23 doi: 10.1007/s12072-021-10257-9. PMID: 34687434
Hepatitis in children with tuberculosis: a case report and review of the literature.
Sanchez-Codez M, Hunt WG, Watson J, Mejias A
BMC Pulm Med 2020 Jun 16;20(1):173. doi: 10.1186/s12890-020-01215-6. PMID: 32546255Free PMC Article
Defining 'Satisfactory Response' to Therapy in Abdominal Tuberculosis: A Work in Progress.
Sharma V, Singh H, Mandavdhare HS
Infect Disord Drug Targets 2020;20(2):111-114. doi: 10.2174/1871526518666181022111323. PMID: 30345933
Pulmonary tuberculosis combined with hepatic tuberculosis: a case report and literature review.
Liao JR, Zhang D, Wu XL
Clin Respir J 2015 Oct;9(4):501-5. Epub 2014 Jun 25 doi: 10.1111/crj.12167. PMID: 24865423
Tuberculosis and liver disease: management issues.
Sonika U, Kar P
Trop Gastroenterol 2012 Apr-Jun;33(2):102-6. doi: 10.7869/tg.2012.25. PMID: 23025055

Prognosis

The impersonator.
Lode H, Wagner J, Scherübl H
Am J Med 2007 Mar;120(3):239-41. doi: 10.1016/j.amjmed.2007.01.019. PMID: 17349446
Hepatic tuberculosis in absence of disseminated abdominal tuberculosis.
Desai CS, Josh AG, Abraham P, Desai DC, Deshpande RB, Bhaduri A, Shah SR
Ann Hepatol 2006 Jan-Mar;5(1):41-3. PMID: 16531964
Hepatobiliary tuberculosis.
Alvarez SZ
J Gastroenterol Hepatol 1998 Aug;13(8):833-9. doi: 10.1111/j.1440-1746.1998.tb00743.x. PMID: 9736180
The renaissance of abdominal tuberculosis.
Jayanthi V, Probert CS, Sher KS, Wicks AC, Mayberry JF
Dig Dis 1993;11(1):36-44. doi: 10.1159/000171399. PMID: 8443955
Hepatobiliary tuberculosis.
Alvarez SZ, Carpio R
Dig Dis Sci 1983 Mar;28(3):193-200. doi: 10.1007/BF01295113. PMID: 6825541

Clinical prediction guides

Characterization of pathological features and immune microenvironment in hepatic tuberculosis and pulmonary tuberculosis.
Niu Q, Wu R, Pan K, Ge X, Chen W, Liu R
Front Cell Infect Microbiol 2024;14:1418225. Epub 2024 Sep 30 doi: 10.3389/fcimb.2024.1418225. PMID: 39403208Free PMC Article
Hepatic tuberculosis masquerading as malignancy.
Kale A, Patil PS, Chhanchure U, Deodhar K, Kulkarni S, Mehta S, Tandon S
Hepatol Int 2022 Apr;16(2):463-472. Epub 2021 Oct 23 doi: 10.1007/s12072-021-10257-9. PMID: 34687434
Diagnostic imaging of hepatic tuberculosis: case series.
Schininà V, Albarello F, Cristofaro M, Di Stefano F, Fusco N, Cuzzi G, Arend SM, Goletti D, Busi Rizzi E
Int J Tuberc Lung Dis 2018 Jul 1;22(7):779-787. doi: 10.5588/ijtld.17.0710. PMID: 29914604
Ultrasound in abdominal tuberculosis.
Malik A, Saxena NC
Abdom Imaging 2003 Jul-Aug;28(4):574-9. doi: 10.1007/s00261-002-0061-z. PMID: 14580103
Peritoneal tuberculosis.
Jorge AD
Endoscopy 1984 Jan;16(1):10-2. doi: 10.1055/s-2007-1018516. PMID: 6230225

Recent systematic reviews

Appropriate chemopreventive strategy for anti-tubercular therapy related liver injury is unsettled: Results from a systematic review and network meta-analysis.
Singh AK, Verma S, Kumar-M P, Soni H, Sharma S, Sharma S, Patil A, Sharma V
Expert Rev Clin Pharmacol 2020 Nov;13(11):1253-1262. Epub 2020 Oct 27 doi: 10.1080/17512433.2020.1835468. PMID: 33043729
Diagnosis and treatment of congenital tuberculosis: a systematic review of 92 cases.
Li C, Liu L, Tao Y
Orphanet J Rare Dis 2019 Jun 10;14(1):131. doi: 10.1186/s13023-019-1101-x. PMID: 31182120Free PMC Article
A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection.
Hickey AJ, Gounder L, Moosa MY, Drain PK
BMC Infect Dis 2015 May 6;15:209. doi: 10.1186/s12879-015-0944-6. PMID: 25943103Free PMC Article

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