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Retinopathy of prematurity plus

MedGen UID:
1634291
Concept ID:
C4703701
Disease or Syndrome
Synonym: ROP plus
 
HPO: HP:0500062

Definition

Venous dilatation and arteriolar tortuosity of the posterior retinal vessels and may later increase in severity to include iris vascular engorgement, poor pupillary dilatation (rigid pupil), and vitreous haze. This definition has been further refined in the later clinical trials in which the diagnosis of plus disease could be made if sufficient vascular dilatation and tortuosity are present in at least 2 quadrants of the eye. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinopathy of prematurity plus

Professional guidelines

PubMed

Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article
Hartnett ME
Curr Opin Ophthalmol 2017 May;28(3):282-288. doi: 10.1097/ICU.0000000000000360. PMID: 28141765Free PMC Article
Cernichiaro-Espinosa LA, Olguin-Manriquez FJ, Henaine-Berra A, Garcia-Aguirre G, Quiroz-Mercado H, Martinez-Castellanos MA
Int Ophthalmol 2016 Oct;36(5):751-60. Epub 2016 Jan 14 doi: 10.1007/s10792-016-0177-8. PMID: 26767656

Recent clinical studies

Etiology

Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Ghergherehchi L, Kim SJ, Campbell JP, Ostmo S, Chan RVP, Chiang MF
Asia Pac J Ophthalmol (Phila) 2018 May-Jun;7(3):152-155. Epub 2018 May 24 doi: 10.22608/APO.201863. PMID: 29797825Free PMC Article
Reynolds JD
Am Orthopt J 2014;64:43-53. doi: 10.3368/aoj.64.1.43. PMID: 25313111
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Diagnosis

Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A, Binenbaum G, Blair M, Peter Campbell J, Capone A Jr, Chen Y, Dai S, Ells A, Fleck BW, Good WV, Elizabeth Hartnett M, Holmstrom G, Kusaka S, Kychenthal A, Lepore D, Lorenz B, Martinez-Castellanos MA, Özdek Ş, Ademola-Popoola D, Reynolds JD, Shah PK, Shapiro M, Stahl A, Toth C, Vinekar A, Visser L, Wallace DK, Wu WC, Zhao P, Zin A
Ophthalmology 2021 Oct;128(10):e51-e68. Epub 2021 Jul 8 doi: 10.1016/j.ophtha.2021.05.031. PMID: 34247850Free PMC Article
Scruggs BA, Chan RVP, Kalpathy-Cramer J, Chiang MF, Campbell JP
Transl Vis Sci Technol 2020 Feb 10;9(2):5. doi: 10.1167/tvst.9.2.5. PMID: 32704411Free PMC Article
Cernichiaro-Espinosa LA, Olguin-Manriquez FJ, Henaine-Berra A, Garcia-Aguirre G, Quiroz-Mercado H, Martinez-Castellanos MA
Int Ophthalmol 2016 Oct;36(5):751-60. Epub 2016 Jan 14 doi: 10.1007/s10792-016-0177-8. PMID: 26767656
Davitt BV, Wallace DK
Surv Ophthalmol 2009 Nov-Dec;54(6):663-70. Epub 2009 Aug 8 doi: 10.1016/j.survophthal.2009.02.021. PMID: 19665743
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Therapy

Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Hartnett ME, Toth CA
Ophthalmic Surg Lasers Imaging Retina 2019 Apr 1;50(4):228-234. doi: 10.3928/23258160-20190401-05. PMID: 30998244
Reynolds JD
Am Orthopt J 2014;64:43-53. doi: 10.3368/aoj.64.1.43. PMID: 25313111
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article
Davitt BV, Wallace DK
Surv Ophthalmol 2009 Nov-Dec;54(6):663-70. Epub 2009 Aug 8 doi: 10.1016/j.survophthal.2009.02.021. PMID: 19665743

Prognosis

Wang J, Ying GS, Yu Y, Tomlinson L, Binenbaum G
Ophthalmic Epidemiol 2023 Oct;30(5):523-531. Epub 2023 Jan 16 doi: 10.1080/09286586.2023.2168014. PMID: 36647265Free PMC Article
Kumawat D, Sachan A, Shah P, Chawla R, Chandra P
Eye (Lond) 2021 Apr;35(4):1140-1158. Epub 2021 Jan 29 doi: 10.1038/s41433-021-01392-6. PMID: 33514899Free PMC Article
Ahmad M, Patnaik J, Thevarajah T, Cathcart J, Jung J, Singh J, Braverman R, Lynch A, McCourt E
J AAPOS 2019 Apr;23(2):90.e1-90.e6. Epub 2019 Feb 14 doi: 10.1016/j.jaapos.2018.10.012. PMID: 30772472
Reynolds JD
Am Orthopt J 2014;64:43-53. doi: 10.3368/aoj.64.1.43. PMID: 25313111
Drenser KA
Dev Ophthalmol 2009;44:89-97. Epub 2009 Jun 3 doi: 10.1159/000223949. PMID: 19494656

Clinical prediction guides

Young BK, Cole ED, Shah PK, Ostmo S, Subramaniam P, Venkatapathy N, Tsai ASH, Coyner AS, Gupta A, Singh P, Chiang MF, Kalpathy-Cramer J, Chan RVP, Campbell JP
JAMA Ophthalmol 2023 Jun 1;141(6):582-588. doi: 10.1001/jamaophthalmol.2023.1466. PMID: 37166816Free PMC Article
Campbell JP, Kim SJ, Brown JM, Ostmo S, Chan RVP, Kalpathy-Cramer J, Chiang MF; of the Imaging and Informatics in Retinopathy of Prematurity Consortium
Ophthalmology 2021 Jul;128(7):1070-1076. Epub 2020 Oct 27 doi: 10.1016/j.ophtha.2020.10.025. PMID: 33121959Free PMC Article
Chang YS, Chen YT, Lai TT, Chou HC, Chen CY, Hsieh WS, Yang CM, Yeh PT, Tsao PN
PLoS One 2019;14(10):e0223972. Epub 2019 Oct 16 doi: 10.1371/journal.pone.0223972. PMID: 31618256Free PMC Article
Hartnett ME, Toth CA
Ophthalmic Surg Lasers Imaging Retina 2019 Apr 1;50(4):228-234. doi: 10.3928/23258160-20190401-05. PMID: 30998244
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Recent systematic reviews

Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article
Sankar MJ, Sankar J, Chandra P
Cochrane Database Syst Rev 2018 Jan 8;1(1):CD009734. doi: 10.1002/14651858.CD009734.pub3. PMID: 29308602Free PMC Article
Sankar MJ, Sankar J, Mehta M, Bhat V, Srinivasan R
Cochrane Database Syst Rev 2016;2:CD009734. Epub 2016 Feb 27 doi: 10.1002/14651858.CD009734.pub2. PMID: 26932750
Cernichiaro-Espinosa LA, Olguin-Manriquez FJ, Henaine-Berra A, Garcia-Aguirre G, Quiroz-Mercado H, Martinez-Castellanos MA
Int Ophthalmol 2016 Oct;36(5):751-60. Epub 2016 Jan 14 doi: 10.1007/s10792-016-0177-8. PMID: 26767656
Kemper AR, Wallace DK, Quinn GE
Pediatrics 2008 Oct;122(4):825-30. doi: 10.1542/peds.2007-3667. PMID: 18829807Free PMC Article

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