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Locally Advanced Lung Adenocarcinoma

MedGen UID:
1763375
•Concept ID:
C5421212
•
Neoplastic Process

Definition

Lung adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Lung Adenocarcinoma

Professional guidelines

PubMed

Recent evidence, advances, and current practices in surgical treatment of lung cancer.
Suda K, Sato K, Mizuuchi H, Kobayashi Y, Shimoji M, Tomizawa K, Takemoto T, Iwasaki T, Sakaguchi M, Mitsudomi T
Respir Investig 2014 Nov;52(6):322-9. Epub 2014 Jul 11 doi: 10.1016/j.resinv.2014.06.003. PMID: 25453375
The diagnosis and treatment of brain metastases in EGFR mutant lung cancer.
Minchom A, Yu KC, Bhosle J, O'Brien M
CNS Oncol 2014 May;3(3):209-17. doi: 10.2217/cns.14.19. PMID: 25055129Free PMC Article
Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship.
Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA
Mayo Clin Proc 2008 May;83(5):584-94. doi: 10.4065/83.5.584. PMID: 18452692Free PMC Article

Recent clinical studies

Etiology

Non-tuberculous mycobacteria lung disease due to Mycobacterium chimaera in a 67-year-old man treated with immune checkpoint inhibitors for lung adenocarcinoma: infection due to dysregulated immunity?
Azzarà C, Lombardi A, Gramegna A, Ori M, Gori A, Blasi F, Bandera A
BMC Infect Dis 2023 Sep 4;23(1):573. doi: 10.1186/s12879-023-08537-w. PMID: 37667178Free PMC Article
A case report of sustained clinical remission in patients with locally advanced lung adenocarcinoma after sequential immunotherapy following concurrent chemoradiotherapy.
Chen W, Zhang H, Huang W, Lan T
Ann Palliat Med 2020 Nov;9(6):4346-4352. doi: 10.21037/apm-20-1773. PMID: 33302686
EGFR Mutation Impact on Definitive Concurrent Chemoradiation Therapy for Inoperable Stage III Adenocarcinoma.
Tanaka K, Hida T, Oya Y, Oguri T, Yoshida T, Shimizu J, Horio Y, Hata A, Kaji R, Fujita S, Sekido Y, Kodaira T, Kokubo M, Katakami N, Yatabe Y
J Thorac Oncol 2015 Dec;10(12):1720-5. doi: 10.1097/JTO.0000000000000675. PMID: 26743855
The impact of clinical outcomes according to EGFR mutation status in patients with locally advanced lung adenocarcinoma who recieved concurrent chemoradiotherapy.
Akamatsu H, Kaira K, Murakami H, Serizawa M, Koh Y, Ono A, Shukuya T, Tsuya A, Nakamura Y, Kenmotsu H, Naito T, Takahashi T, Endo M, Harada H, Nakajima T, Yamamoto N
Am J Clin Oncol 2014 Apr;37(2):144-7. doi: 10.1097/COC.0b013e31826e04f9. PMID: 23211219
Whole-tumor perfusion CT in patients with advanced lung adenocarcinoma treated with conventional and antiangiogenetic chemotherapy: initial experience.
Fraioli F, Anzidei M, Zaccagna F, Mennini ML, Serra G, Gori B, Longo F, Catalano C, Passariello R
Radiology 2011 May;259(2):574-82. Epub 2011 Feb 25 doi: 10.1148/radiol.11100600. PMID: 21357523

Diagnosis

Neoadjuvant alectinib in locally advanced lung adenocarcinoma with anaplastic lymphoma kinase rearrangement: case series and literature review.
Wang Z, Wu R, Li C, Cheng K, Di Y, Lv T, Liu H, Song Y
Anticancer Drugs 2023 Nov 1;34(10):1069-1075. Epub 2023 Jan 24 doi: 10.1097/CAD.0000000000001507. PMID: 36688904
A case report of sustained clinical remission in patients with locally advanced lung adenocarcinoma after sequential immunotherapy following concurrent chemoradiotherapy.
Chen W, Zhang H, Huang W, Lan T
Ann Palliat Med 2020 Nov;9(6):4346-4352. doi: 10.21037/apm-20-1773. PMID: 33302686
Targeted Therapy Followed by Cytotoxic Chemotherapy in Preoperative Patients With Locally Advanced Lung Adenocarcinoma.
Aoki M, Ueda K, Umehara T, Kamimura GO, Tokunaga T, Harada-Takeda A, Maeda K, Nagata T, Yokomakura N, Kariatsumari K, Nonaka Y, Imamura N, Morizono S, Sato M
Anticancer Res 2020 May;40(5):2911-2916. doi: 10.21873/anticanres.14268. PMID: 32366442
A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts.
Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jäger D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U
J Nucl Med 2018 Sep;59(9):1423-1429. Epub 2018 Apr 6 doi: 10.2967/jnumed.118.210435. PMID: 29626120Free PMC Article
IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling.
Gao Y, Yang J, Cai Y, Fu S, Zhang N, Fu X, Li L
Int J Cancer 2018 Aug 15;143(4):931-943. Epub 2018 Mar 25 doi: 10.1002/ijc.31357. PMID: 29516506

Therapy

Non-tuberculous mycobacteria lung disease due to Mycobacterium chimaera in a 67-year-old man treated with immune checkpoint inhibitors for lung adenocarcinoma: infection due to dysregulated immunity?
Azzarà C, Lombardi A, Gramegna A, Ori M, Gori A, Blasi F, Bandera A
BMC Infect Dis 2023 Sep 4;23(1):573. doi: 10.1186/s12879-023-08537-w. PMID: 37667178Free PMC Article
Neoadjuvant alectinib in locally advanced lung adenocarcinoma with anaplastic lymphoma kinase rearrangement: case series and literature review.
Wang Z, Wu R, Li C, Cheng K, Di Y, Lv T, Liu H, Song Y
Anticancer Drugs 2023 Nov 1;34(10):1069-1075. Epub 2023 Jan 24 doi: 10.1097/CAD.0000000000001507. PMID: 36688904
Complete response induced by anti-PD-1-based immunotherapy with toripalimab in a patient with locally advanced lung adenocarcinoma who failed rapidly after concurrent chemoradiotherapy: A case report.
Xue W, Zhang T, Wang X, Duan J, Bi N
J Clin Pharm Ther 2020 Dec;45(6):1511-1514. Epub 2020 Sep 7 doi: 10.1111/jcpt.13248. PMID: 32893899
Surgical resection of locally advanced epidermal growth factor receptor (EGFR) mutated lung adenocarcinoma after gefitinib and review of the literature.
Marech I, Vacca A, Gnoni A, Silvestris N, Lorusso V
Tumori 2013 Sep-Oct;99(5):e241-4. doi: 10.1177/030089161309900522. PMID: 24362878
Whole-tumor perfusion CT in patients with advanced lung adenocarcinoma treated with conventional and antiangiogenetic chemotherapy: initial experience.
Fraioli F, Anzidei M, Zaccagna F, Mennini ML, Serra G, Gori B, Longo F, Catalano C, Passariello R
Radiology 2011 May;259(2):574-82. Epub 2011 Feb 25 doi: 10.1148/radiol.11100600. PMID: 21357523

Prognosis

Complete Response of Locally Advanced Lung Adenocarcinoma Following Basil Combined With Cisplatin Plus Pemetrexed Chemotherapy: A Case Report.
He C, Li L, Feng B, Xie L, Zhang L, Liu B
Integr Cancer Ther 2024 Jan-Dec;23:15347354241295269. doi: 10.1177/15347354241295269. PMID: 39511726Free PMC Article
Non-tuberculous mycobacteria lung disease due to Mycobacterium chimaera in a 67-year-old man treated with immune checkpoint inhibitors for lung adenocarcinoma: infection due to dysregulated immunity?
Azzarà C, Lombardi A, Gramegna A, Ori M, Gori A, Blasi F, Bandera A
BMC Infect Dis 2023 Sep 4;23(1):573. doi: 10.1186/s12879-023-08537-w. PMID: 37667178Free PMC Article
IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
Gao Y, Lu J, Zeng C, Yang J, Huang B, Zhang N, Li L, Fu X
Clin Exp Med 2020 Aug;20(3):449-459. Epub 2020 Apr 18 doi: 10.1007/s10238-020-00626-3. PMID: 32306136
A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts.
Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jäger D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U
J Nucl Med 2018 Sep;59(9):1423-1429. Epub 2018 Apr 6 doi: 10.2967/jnumed.118.210435. PMID: 29626120Free PMC Article
IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling.
Gao Y, Yang J, Cai Y, Fu S, Zhang N, Fu X, Li L
Int J Cancer 2018 Aug 15;143(4):931-943. Epub 2018 Mar 25 doi: 10.1002/ijc.31357. PMID: 29516506

Clinical prediction guides

A case of neoadjuvant targeted therapy with pralsetinib for locally advanced lung adenocarcinoma with RET fusion mutation.
Chunmao W, Haijie C, Zitong W, Zhi Y
J Cardiothorac Surg 2024 Oct 1;19(1):554. doi: 10.1186/s13019-024-03092-0. PMID: 39354540Free PMC Article
IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling.
Gao Y, Yang J, Cai Y, Fu S, Zhang N, Fu X, Li L
Int J Cancer 2018 Aug 15;143(4):931-943. Epub 2018 Mar 25 doi: 10.1002/ijc.31357. PMID: 29516506
Malignant meningitis secondary to lung adenocarcinoma: an unusual relapse.
Ano S, Satoh H, Nakazawa K, Ohtsuka M, Anami Y, Noguchi M, Hizawa N
Intern Med 2007;46(20):1749-51. Epub 2007 Oct 15 doi: 10.2169/internalmedicine.46.0277. PMID: 17938533
Intrapleural administration of interleukin-2 and LAK cells in locally advanced non-small-cell lung cancer. A case report.
Matteucci P, Tresoldi M, Chiesa G, Tognella S, Citterio G, Fortis C, Besana C, Rugarli C
Tumori 1994 Jun 30;80(3):246-50. doi: 10.1177/030089169408000317. PMID: 8053086

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