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Advanced Lung Adenosquamous Carcinoma

MedGen UID:
1793835
•Concept ID:
C5557394
•
Neoplastic Process

Definition

Lung adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Lung Adenosquamous Carcinoma

Professional guidelines

PubMed

Efficacy, safety, and prognostic factors of anlotinib treatment in advanced non-small cell lung cancer patients.
Huang A, Wang W, Qin R, Chen G, Gu A, Han B
J Cancer Res Ther 2022 Sep;18(5):1299-1305. doi: 10.4103/jcrt.jcrt_835_21. PMID: 36204876
Primary lung carcinoma in children and adolescents: An analysis of the European Cooperative Study Group on Paediatric Rare Tumours (EXPeRT).
Abele M, Bajčiová V, Wright F, Behjati S, Voggel S, Schneider DT, Mallebranche C, Česen Mazič M, Guillén G, Krawczyk M, Bień E, Roganovic J, Bisogno G, Chiaravalli S, Ferrari A, Brecht IB, Orbach D, Reguerre Y, Virgone C
Eur J Cancer 2022 Nov;175:19-30. Epub 2022 Sep 7 doi: 10.1016/j.ejca.2022.08.007. PMID: 36087394
Newly Diagnosed Lung Cancer: Which Molecular Tests Are Needed for Optimal Treatment Decision Making?
Ganti AK
Oncology (Williston Park) 2018 Jun;32(6):276-80. PMID: 29940057

Recent clinical studies

Etiology

Genomic landscape of non-small-cell lung cancer with methylthioadenosine phosphorylase (MTAP) deficiency.
Ashok Kumar P, Graziano SL, Danziger N, Pavlick D, Severson EA, Ramkissoon SH, Huang RSP, Decker B, Ross JS
Cancer Med 2023 Jan;12(2):1157-1166. Epub 2022 Jun 23 doi: 10.1002/cam4.4971. PMID: 35747993Free PMC Article
A competing risk nomogram predicting cause-specific mortality in patients with lung adenosquamous carcinoma.
Wu X, Yu W, Petersen RH, Sheng H, Wang Y, Lv W, Hu J
BMC Cancer 2020 May 16;20(1):429. doi: 10.1186/s12885-020-06927-w. PMID: 32416716Free PMC Article
Therapeutic efficacy of gefitinib and erlotinib in patients with advanced lung adenosquamous carcinoma.
Song Z, Lin B, Shao L, Zhang Y
J Chin Med Assoc 2013 Sep;76(9):481-5. Epub 2013 Jun 13 doi: 10.1016/j.jcma.2013.05.007. PMID: 23769878
Adenosquamous and squamous carcinoma of the colon and upper rectum: a clinical and histopathologic study.
Frizelle FA, Hobday KS, Batts KP, Nelson H
Dis Colon Rectum 2001 Mar;44(3):341-6. doi: 10.1007/BF02234730. PMID: 11289278
Carcinoma of the lung in Okinawa, Japan: with special reference to squamous cell carcinoma and squamous metaplasia.
Nakazato I, Hirayasu T, Kamada Y, Tsuhako K, Iwamasa T
Pathol Int 1997 Oct;47(10):659-72. doi: 10.1111/j.1440-1827.1997.tb04439.x. PMID: 9361099

Diagnosis

Neoadjuvant ceritinib treatment in ALK-rearranged locally advanced adenosquamous carcinoma: A case report.
Mai S, Wang Y, Wang X, Yang W, Gao H, Xu Z, Xu L, Xu L, Ou Q, Chen H, Wang Z
Thorac Cancer 2022 Aug;13(15):2275-2278. Epub 2022 Jul 12 doi: 10.1111/1759-7714.14558. PMID: 35818908Free PMC Article
Hypercalcemia-Leukocytosis syndrome and adenosquamous lung carcinoma: An overlooked conjugation.
Oliveira Pereira J, Gama J, Ferreira D, Santos A
Oncol Res 2021;29(2):81-85. Epub 2022 Jul 13 doi: 10.32604/or.2022.023450. PMID: 37305400Free PMC Article
A competing risk nomogram predicting cause-specific mortality in patients with lung adenosquamous carcinoma.
Wu X, Yu W, Petersen RH, Sheng H, Wang Y, Lv W, Hu J
BMC Cancer 2020 May 16;20(1):429. doi: 10.1186/s12885-020-06927-w. PMID: 32416716Free PMC Article
Lung Cancer in the Young.
Galvez-Nino M, Ruiz R, Pinto JA, Roque K, Mantilla R, Raez LE, Mas L
Lung 2020 Feb;198(1):195-200. Epub 2019 Nov 26 doi: 10.1007/s00408-019-00294-5. PMID: 31773258
Pathology of lung cancer.
Travis WD
Clin Chest Med 2011 Dec;32(4):669-92. doi: 10.1016/j.ccm.2011.08.005. PMID: 22054879

Therapy

Subtyping of advanced lung cancer based on PD-L1 expression, tumor histopathology and mutation burden (EGFR and KRAS): a study from North India.
Kulshrestha R, Saxena H, Kumar R, Spalgais S, Mrigpuri P, Goel N, Menon B, Rani M, Mahor P, Bhutani I
Monaldi Arch Chest Dis 2023 Feb 1;93(4) doi: 10.4081/monaldi.2023.2449. PMID: 36723380
Efficacy, safety, and prognostic factors of anlotinib treatment in advanced non-small cell lung cancer patients.
Huang A, Wang W, Qin R, Chen G, Gu A, Han B
J Cancer Res Ther 2022 Sep;18(5):1299-1305. doi: 10.4103/jcrt.jcrt_835_21. PMID: 36204876
Neoadjuvant ceritinib treatment in ALK-rearranged locally advanced adenosquamous carcinoma: A case report.
Mai S, Wang Y, Wang X, Yang W, Gao H, Xu Z, Xu L, Xu L, Ou Q, Chen H, Wang Z
Thorac Cancer 2022 Aug;13(15):2275-2278. Epub 2022 Jul 12 doi: 10.1111/1759-7714.14558. PMID: 35818908Free PMC Article
Surgical outcomes and complications of pneumonectomy after induction therapy for non-small cell lung cancer.
Kayawake H, Okumura N, Yamanashi K, Otsuki Y, Takahashi A, Itasaka S, Yoshioka H, Nakashima T, Matsuoka T
Gen Thorac Cardiovasc Surg 2018 Nov;66(11):658-663. Epub 2018 Aug 6 doi: 10.1007/s11748-018-0980-4. PMID: 30083866
Therapeutic efficacy of gefitinib and erlotinib in patients with advanced lung adenosquamous carcinoma.
Song Z, Lin B, Shao L, Zhang Y
J Chin Med Assoc 2013 Sep;76(9):481-5. Epub 2013 Jun 13 doi: 10.1016/j.jcma.2013.05.007. PMID: 23769878

Prognosis

Genomic landscape of non-small-cell lung cancer with methylthioadenosine phosphorylase (MTAP) deficiency.
Ashok Kumar P, Graziano SL, Danziger N, Pavlick D, Severson EA, Ramkissoon SH, Huang RSP, Decker B, Ross JS
Cancer Med 2023 Jan;12(2):1157-1166. Epub 2022 Jun 23 doi: 10.1002/cam4.4971. PMID: 35747993Free PMC Article
Hypercalcemia-Leukocytosis syndrome and adenosquamous lung carcinoma: An overlooked conjugation.
Oliveira Pereira J, Gama J, Ferreira D, Santos A
Oncol Res 2021;29(2):81-85. Epub 2022 Jul 13 doi: 10.32604/or.2022.023450. PMID: 37305400Free PMC Article
A competing risk nomogram predicting cause-specific mortality in patients with lung adenosquamous carcinoma.
Wu X, Yu W, Petersen RH, Sheng H, Wang Y, Lv W, Hu J
BMC Cancer 2020 May 16;20(1):429. doi: 10.1186/s12885-020-06927-w. PMID: 32416716Free PMC Article
Lung Cancer in the Young.
Galvez-Nino M, Ruiz R, Pinto JA, Roque K, Mantilla R, Raez LE, Mas L
Lung 2020 Feb;198(1):195-200. Epub 2019 Nov 26 doi: 10.1007/s00408-019-00294-5. PMID: 31773258
Adenosquamous and squamous carcinoma of the colon and upper rectum: a clinical and histopathologic study.
Frizelle FA, Hobday KS, Batts KP, Nelson H
Dis Colon Rectum 2001 Mar;44(3):341-6. doi: 10.1007/BF02234730. PMID: 11289278

Clinical prediction guides

Lung cancer presenting with central nervous system metastasis: Clinicopathological and molecular analysis of 171 cases.
Demleitner M, Erlenbach-Wünsch K, Coras R, Erber R, Polifka I, Eyüpoğlu I, Fuchs F, Hartmann A, Agaimy A
Ann Diagn Pathol 2023 Apr;63:152082. Epub 2022 Dec 23 doi: 10.1016/j.anndiagpath.2022.152082. PMID: 36634550
Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation.
Fang Z, Han X, Chen Y, Tong X, Xue Y, Yao S, Tang S, Pan Y, Sun Y, Wang X, Jin Y, Chen H, Hu L, Hui L, Li L, Chen L, Ji H
Signal Transduct Target Ther 2023 Jan 11;8(1):16. doi: 10.1038/s41392-022-01227-0. PMID: 36627278Free PMC Article
Genomic landscape of non-small-cell lung cancer with methylthioadenosine phosphorylase (MTAP) deficiency.
Ashok Kumar P, Graziano SL, Danziger N, Pavlick D, Severson EA, Ramkissoon SH, Huang RSP, Decker B, Ross JS
Cancer Med 2023 Jan;12(2):1157-1166. Epub 2022 Jun 23 doi: 10.1002/cam4.4971. PMID: 35747993Free PMC Article
Molecular and expressional characterization of tumor heterogeneity in pulmonary carcinosarcoma.
Ohtaki Y, Kawabata-Iwakawa R, Nobusawa S, Goto Y, Shimizu K, Yajima T, Nakazawa S, Kawatani N, Yoshida Y, Sano T, Shirabe K
Mol Carcinog 2022 Oct;61(10):924-932. Epub 2022 Jul 18 doi: 10.1002/mc.23448. PMID: 35848137
A competing risk nomogram predicting cause-specific mortality in patients with lung adenosquamous carcinoma.
Wu X, Yu W, Petersen RH, Sheng H, Wang Y, Lv W, Hu J
BMC Cancer 2020 May 16;20(1):429. doi: 10.1186/s12885-020-06927-w. PMID: 32416716Free PMC Article

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