From HPO
Crohn disease- MedGen UID:
- 3664
- •Concept ID:
- C0010346
- •
- Disease or Syndrome
A chronic granulomatous inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms. It primarily causes abdominal pain, diarrhea which may be bloody, vomiting, or weight loss, but may also cause complications outside of the gastrointestinal tract such as skin rashes, arthritis, inflammation of the eye, tiredness, and lack of concentration. Crohn's disease is thought to be an autoimmune disease, in which the body's immune system attacks the gastrointestinal tract, causing inflammation.
Hypochromic microcytic anemia- MedGen UID:
- 124413
- •Concept ID:
- C0271901
- •
- Disease or Syndrome
A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes and lower than normal size of the erythrocytes.
Bronchiectasis- MedGen UID:
- 14234
- •Concept ID:
- C0006267
- •
- Disease or Syndrome
Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways.
Pulmonary bulla- MedGen UID:
- 537120
- •Concept ID:
- C0241982
- •
- Disease or Syndrome
Pulmonary bullae are rounded focal regions of emphysema with a thin wall which measure more than 1 cm in diameter. They are often subpleural in location and are typically larger in the apices. In some cases, bullae can be very large and result in compression of adjacent lung tissue. A giant bulla is arbitrarily defined as one that occupies at least one third of the volume of a hemithorax. When large, bullae can simulate pneumothorax. The most common cause is paraseptal emphysema but bullae may also be seen in association with centrilobular emphysema.
Pleural thickening- MedGen UID:
- 538648
- •Concept ID:
- C0264545
- •
- Disease or Syndrome
An increase in the thickness of the pleura, generally related to scarring of the pleural tissue.
Recurrent lower respiratory tract infections- MedGen UID:
- 756211
- •Concept ID:
- C3163798
- •
- Disease or Syndrome
An increased susceptibility to lower respiratory tract infections as manifested by a history of recurrent lower respiratory tract infections.
Asthma- MedGen UID:
- 2109
- •Concept ID:
- C0004096
- •
- Disease or Syndrome
Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing.
Rheumatoid factor positive- MedGen UID:
- 56226
- •Concept ID:
- C0151379
- •
- Laboratory or Test Result
The presence in the serum of an autoantibody directed against the Fc portion of IgG.
Antinuclear antibody positivity- MedGen UID:
- 101792
- •Concept ID:
- C0151480
- •
- Laboratory or Test Result
The presence of autoantibodies in the serum that react against nuclei or nuclear components.
Increased circulating IgE concentration- MedGen UID:
- 116018
- •Concept ID:
- C0236175
- •
- Finding
An abnormally increased overall level of immunoglobulin E in blood.
Increased circulating IgA concentration- MedGen UID:
- 66800
- •Concept ID:
- C0239984
- •
- Finding
An abnormally increased level of immunoglobulin A in blood.
Decreased eosinophil count- MedGen UID:
- 1630945
- •Concept ID:
- C0854104
- •
- Finding
Abnormal reduction in the count of eosinophils in the blood per volume.
Increased circulating IgG concentration- MedGen UID:
- 347032
- •Concept ID:
- C1858977
- •
- Finding
An abnormally increased level of immunoglobulin G in blood.
Anti-thyroglobulin antibody positivity- MedGen UID:
- 1670955
- •Concept ID:
- C4732836
- •
- Finding
The presence of autoantibodies (immunoglobulins) in the serum that react to thyroglobulin.
Reduced circulating interleukin 10 concentration- MedGen UID:
- 1814327
- •Concept ID:
- C5676758
- •
- Finding
An abnormally decreased concentration of interleukin 10 in the blood circulation.
Reduced circulating interleukin 21 concentration- MedGen UID:
- 1814329
- •Concept ID:
- C5676760
- •
- Finding
An abnormally decreased concentration of interleukin 21 in the blood circulation.
Reduced circulating interleukin 22 concentration- MedGen UID:
- 1814332
- •Concept ID:
- C5676763
- •
- Finding
An abnormally decreased concentration of interleukin 22 in the blood circulation.
Reduced circulating interleukin 23 concentration- MedGen UID:
- 1814335
- •Concept ID:
- C5676766
- •
- Finding
An abnormally decreased concentration of interleukin 23 in the blood circulation.
Reduced circulating interleukin 27 concentration- MedGen UID:
- 1814338
- •Concept ID:
- C5676769
- •
- Finding
An abnormally decreased concentration of interleukin 27 in the blood circulation.
Reduced circulating interleukin 17A concentration- MedGen UID:
- 1814341
- •Concept ID:
- C5676772
- •
- Finding
An abnormally decreased concentration of interleukin 17A in the blood circulation.
Elevated erythrocyte sedimentation rate- MedGen UID:
- 57727
- •Concept ID:
- C0151632
- •
- Finding
An increased erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen.
Elevated circulating C-reactive protein concentration- MedGen UID:
- 892906
- •Concept ID:
- C4023452
- •
- Finding
An abnormal elevation of the C-reactive protein level in the blood circulation.
- Abnormality of blood and blood-forming tissues
- Abnormality of metabolism/homeostasis
- Abnormality of the digestive system
- Abnormality of the immune system
- Abnormality of the respiratory system