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Lung combined large cell neuroendocrine carcinoma

MedGen UID:
232386
Concept ID:
C1333122
Neoplastic Process
Synonyms: Combined Large Cell Lung Neuroendocrine Carcinoma; combined large cell lung neuroendocrine carcinoma; Combined Large Cell Neuroendocrine Carcinoma of Lung; combined large cell neuroendocrine carcinoma of lung; Combined Large Cell Neuroendocrine Carcinoma of the Lung; combined large cell neuroendocrine carcinoma of the lung; Combined Lung Large Cell Neuroendocrine Carcinoma; Lung Combined Large Cell Neuroendocrine Carcinoma; lung combined large cell neuroendocrine carcinoma; Pulmonary Combined Large Cell Neuroendocrine Carcinoma; pulmonary combined large cell neuroendocrine carcinoma
 
Monarch Initiative: MONDO:0004142

Definition

A subtype of large cell neuroendocrine lung carcinoma characterized by the presence of large neuroendocrine cells in combination with adenocarcinoma, squamous cell carcinoma, giant cell carcinoma and/ or spindle cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung combined large cell neuroendocrine carcinoma

Professional guidelines

PubMed

Thomas KEH, Voros BA, Boudreaux JP, Thiagarajan R, Woltering EA, Ramirez RA
Oncologist 2019 Aug;24(8):1076-1088. Epub 2019 Jan 11 doi: 10.1634/theoncologist.2018-0604. PMID: 30635447Free PMC Article
Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC
Tumour Biol 2016 Jun;37(6):7047-57. Epub 2016 Mar 4 doi: 10.1007/s13277-016-5003-4. PMID: 26943800
Iyoda A, Makino T, Koezuka S, Otsuka H, Hata Y
Gen Thorac Cardiovasc Surg 2014 Jun;62(6):351-6. Epub 2014 Apr 10 doi: 10.1007/s11748-014-0379-9. PMID: 24719260Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Ashok Kumar P, Graziano SL, Danziger N, Pavlick D, Severson EA, Ramkissoon SH, Huang RSP, Decker B, Ross JS
Cancer Med 2023 Jan;12(2):1157-1166. Epub 2022 Jun 23 doi: 10.1002/cam4.4971. PMID: 35747993Free PMC Article
Li M, Yang L, Lu H
Pathol Oncol Res 2022;28:1610747. Epub 2022 Nov 23 doi: 10.3389/pore.2022.1610747. PMID: 36507119Free PMC Article
Metovic J, Bianchi F, Rossi G, Barella M, Sonzogni A, Harari S, Papotti M, Pelosi G
Semin Diagn Pathol 2021 Sep;38(5):90-97. Epub 2021 Mar 19 doi: 10.1053/j.semdp.2021.03.002. PMID: 33810912
Miyoshi T, Umemura S, Matsumura Y, Mimaki S, Tada S, Makinoshima H, Ishii G, Udagawa H, Matsumoto S, Yoh K, Niho S, Ohmatsu H, Aokage K, Hishida T, Yoshida J, Nagai K, Goto K, Tsuboi M, Tsuchihara K
Clin Cancer Res 2017 Feb 1;23(3):757-765. Epub 2016 Aug 9 doi: 10.1158/1078-0432.CCR-16-0355. PMID: 27507618
Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC
Tumour Biol 2016 Jun;37(6):7047-57. Epub 2016 Mar 4 doi: 10.1007/s13277-016-5003-4. PMID: 26943800

Diagnosis

Li M, Yang L, Lu H
Pathol Oncol Res 2022;28:1610747. Epub 2022 Nov 23 doi: 10.3389/pore.2022.1610747. PMID: 36507119Free PMC Article
Megyesfalvi Z, Barany N, Lantos A, Valko Z, Pipek O, Lang C, Schwendenwein A, Oberndorfer F, Paku S, Ferencz B, Dezso K, Fillinger J, Lohinai Z, Moldvay J, Galffy G, Szeitz B, Rezeli M, Rivard C, Hirsch FR, Brcic L, Popper H, Kern I, Kovacevic M, Skarda J, Mittak M, Marko-Varga G, Bogos K, Renyi-Vamos F, Hoda MA, Klikovits T, Hoetzenecker K, Schelch K, Laszlo V, Dome B
J Pathol 2022 Aug;257(5):674-686. Epub 2022 May 25 doi: 10.1002/path.5922. PMID: 35489038Free PMC Article
Metovic J, Bianchi F, Rossi G, Barella M, Sonzogni A, Harari S, Papotti M, Pelosi G
Semin Diagn Pathol 2021 Sep;38(5):90-97. Epub 2021 Mar 19 doi: 10.1053/j.semdp.2021.03.002. PMID: 33810912
Rossi G, Bisagni A, Cavazza A
Curr Opin Pulm Med 2014 Jul;20(4):332-9. doi: 10.1097/MCP.0000000000000061. PMID: 24811834
Gollard R, Jhatakia S, Elliott M, Kosty M
Lung Cancer 2010 Jul;69(1):13-8. Epub 2010 Feb 4 doi: 10.1016/j.lungcan.2009.12.011. PMID: 20133008

Therapy

Li M, Yang L, Lu H
Pathol Oncol Res 2022;28:1610747. Epub 2022 Nov 23 doi: 10.3389/pore.2022.1610747. PMID: 36507119Free PMC Article
Jiang H, Wu Q, Zhong Y
Bull Cancer 2021 Oct;108(10):981-987. Epub 2021 Aug 12 doi: 10.1016/j.bulcan.2021.04.010. PMID: 34392973
Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC
Tumour Biol 2016 Jun;37(6):7047-57. Epub 2016 Mar 4 doi: 10.1007/s13277-016-5003-4. PMID: 26943800
Iyoda A, Makino T, Koezuka S, Otsuka H, Hata Y
Gen Thorac Cardiovasc Surg 2014 Jun;62(6):351-6. Epub 2014 Apr 10 doi: 10.1007/s11748-014-0379-9. PMID: 24719260Free PMC Article
Gollard R, Jhatakia S, Elliott M, Kosty M
Lung Cancer 2010 Jul;69(1):13-8. Epub 2010 Feb 4 doi: 10.1016/j.lungcan.2009.12.011. PMID: 20133008

Prognosis

Ashok Kumar P, Graziano SL, Danziger N, Pavlick D, Severson EA, Ramkissoon SH, Huang RSP, Decker B, Ross JS
Cancer Med 2023 Jan;12(2):1157-1166. Epub 2022 Jun 23 doi: 10.1002/cam4.4971. PMID: 35747993Free PMC Article
Zheng M
Surg Oncol Clin N Am 2016 Jul;25(3):447-68. doi: 10.1016/j.soc.2016.02.003. PMID: 27261908
Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC
Tumour Biol 2016 Jun;37(6):7047-57. Epub 2016 Mar 4 doi: 10.1007/s13277-016-5003-4. PMID: 26943800
Rossi G, Bisagni A, Cavazza A
Curr Opin Pulm Med 2014 Jul;20(4):332-9. doi: 10.1097/MCP.0000000000000061. PMID: 24811834
Gollard R, Jhatakia S, Elliott M, Kosty M
Lung Cancer 2010 Jul;69(1):13-8. Epub 2010 Feb 4 doi: 10.1016/j.lungcan.2009.12.011. PMID: 20133008

Clinical prediction guides

Ashok Kumar P, Graziano SL, Danziger N, Pavlick D, Severson EA, Ramkissoon SH, Huang RSP, Decker B, Ross JS
Cancer Med 2023 Jan;12(2):1157-1166. Epub 2022 Jun 23 doi: 10.1002/cam4.4971. PMID: 35747993Free PMC Article
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Jiang H, Wu Q, Zhong Y
Bull Cancer 2021 Oct;108(10):981-987. Epub 2021 Aug 12 doi: 10.1016/j.bulcan.2021.04.010. PMID: 34392973
Derks JL, Leblay N, Thunnissen E, van Suylen RJ, den Bakker M, Groen HJM, Smit EF, Damhuis R, van den Broek EC, Charbrier A, Foll M, McKay JD, Fernandez-Cuesta L, Speel EM, Dingemans AC; PALGA-Group
Clin Cancer Res 2018 Jan 1;24(1):33-42. Epub 2017 Oct 24 doi: 10.1158/1078-0432.CCR-17-1921. PMID: 29066508
Miyoshi T, Umemura S, Matsumura Y, Mimaki S, Tada S, Makinoshima H, Ishii G, Udagawa H, Matsumoto S, Yoh K, Niho S, Ohmatsu H, Aokage K, Hishida T, Yoshida J, Nagai K, Goto K, Tsuboi M, Tsuchihara K
Clin Cancer Res 2017 Feb 1;23(3):757-765. Epub 2016 Aug 9 doi: 10.1158/1078-0432.CCR-16-0355. PMID: 27507618

Recent systematic reviews

Stoyianni A, Pentheroudakis G, Pavlidis N
Cancer Treat Rev 2011 Aug;37(5):358-65. Epub 2011 Apr 9 doi: 10.1016/j.ctrv.2011.03.002. PMID: 21481536

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

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