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Atypical Adenomatous Lung Hyperplasia

MedGen UID:
272326
•Concept ID:
C1332345
•
Neoplastic Process
Synonyms: Atypical Adenomatous Hyperplasia of Lung; Atypical Adenomatous Hyperplasia of the Lung; Atypical Alveolar Hyperplasia; Bronchioloalveolar Cell Adenoma

Definition

A preinvasive lesion in the lung. It is characterized by the presence of a small, localized proliferation of mildly to moderately atypical type II pneumocytes and/or Clara cells lining alveolar walls and sometimes respiratory bronchioles. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Adenomatous Lung Hyperplasia

Professional guidelines

PubMed

Evaluation of Computer-Aided Nodule Assessment and Risk Yield (CANARY) in Korean patients for prediction of invasiveness of ground-glass opacity nodule.
Lee J, Bartholmai B, Peikert T, Chun J, Kim H, Kim JS, Park SY
PLoS One 2021;16(6):e0253204. Epub 2021 Jun 14 doi: 10.1371/journal.pone.0253204. PMID: 34125856Free PMC Article
Pulmonary ground-glass nodules diagnosis: mean change rate of peak CT number as a discriminative factor of pathology during a follow-up.
Peng M, Li Z, Hu H, Liu S, Xu B, Zhu W, Han Y, Xiong L, Lin Q
Br J Radiol 2016;89(1058):20150556. Epub 2015 Nov 12 doi: 10.1259/bjr.20150556. PMID: 26562098Free PMC Article
Pulmonary atypical adenomatous hyperplasia. A histologic lesion in search of usable criteria and clinical significance.
Ritter JH
Am J Clin Pathol 1999 May;111(5):587-9. doi: 10.1093/ajcp/111.5.587. PMID: 10230347

Recent clinical studies

Etiology

Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing.
Wang Z, Li Z, Zhou K, Wang C, Jiang L, Zhang L, Yang Y, Luo W, Qiao W, Wang G, Ni Y, Dai S, Guo T, Ji G, Xu M, Liu Y, Su Z, Che G, Li W
Nat Commun 2021 Nov 11;12(1):6500. doi: 10.1038/s41467-021-26770-2. PMID: 34764257Free PMC Article
Approach to the Subsolid Nodule.
Mase VJ Jr, Detterbeck FC
Clin Chest Med 2020 Mar;41(1):99-113. doi: 10.1016/j.ccm.2019.11.004. PMID: 32008632
Interstitial lung abnormalities: prognostic stratification of subtle radiological findings.
Silva M, Milanese G, Sverzellati N
Curr Opin Pulm Med 2018 Sep;24(5):432-439. doi: 10.1097/MCP.0000000000000497. PMID: 29939864
Pulmonary preneoplasia--sequential molecular carcinogenetic events.
Lantuéjoul S, Salameire D, Salon C, Brambilla E
Histopathology 2009 Jan;54(1):43-54. doi: 10.1111/j.1365-2559.2008.03182.x. PMID: 19187179
Pulmonary preinvasive neoplasia.
Kerr KM
J Clin Pathol 2001 Apr;54(4):257-71. doi: 10.1136/jcp.54.4.257. PMID: 11304841Free PMC Article

Diagnosis

Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing.
Wang Z, Li Z, Zhou K, Wang C, Jiang L, Zhang L, Yang Y, Luo W, Qiao W, Wang G, Ni Y, Dai S, Guo T, Ji G, Xu M, Liu Y, Su Z, Che G, Li W
Nat Commun 2021 Nov 11;12(1):6500. doi: 10.1038/s41467-021-26770-2. PMID: 34764257Free PMC Article
Approach to the Subsolid Nodule.
Mase VJ Jr, Detterbeck FC
Clin Chest Med 2020 Mar;41(1):99-113. doi: 10.1016/j.ccm.2019.11.004. PMID: 32008632
Diagnostic Difficulties With Atrophy, Atypical Adenomatous Hyperplasia, and Atypical Small Acinar Proliferation: A Systematic Review of Current Literature.
Kowalewski A, Szylberg Ł, Skórczewska A, Marszałek A
Clin Genitourin Cancer 2016 Oct;14(5):361-365. Epub 2016 Feb 23 doi: 10.1016/j.clgc.2016.02.003. PMID: 26992486
Pulmonary preneoplasia.
Dacic S
Arch Pathol Lab Med 2008 Jul;132(7):1073-8. doi: 10.5858/2008-132-1073-PP. PMID: 18605763
Atypical adenomatous hyperplasia of the lung. Implications for the pathogenesis of peripheral lung adenocarcinoma.
Kitamura H, Kameda Y, Ito T, Hayashi H
Am J Clin Pathol 1999 May;111(5):610-22. doi: 10.1093/ajcp/111.5.610. PMID: 10230351

Therapy

Ultrasound location of ground-glass opacity during thoracoscopic surgery.
Messina G, Bove M, Natale G, Noro A, Martone M, Opromolla G, Di Filippo V, Leonardi B, Fasano M, Polito R, Fiorelli A, Santini M, Vicidomini G
Interact Cardiovasc Thorac Surg 2022 Nov 8;35(6) doi: 10.1093/icvts/ivac234. PMID: 36063460Free PMC Article
Lung Findings in a Patient with a History of Nicotine Vaping and Cannabis Smoking.
McCormick W, Baykara Y, Siddique A, Van Truong L, Corbett M, Hacking SM
R I Med J (2013) 2022 Jun 1;105(5):36-40. PMID: 35617040
Lung cancer preneoplasia.
Wistuba II, Gazdar AF
Annu Rev Pathol 2006;1:331-48. doi: 10.1146/annurev.pathol.1.110304.100103. PMID: 18039118
Lung cancer: chemoprevention and intermediate effect markers.
Tockman MS
IARC Sci Publ 2001;154:257-70. PMID: 11220665
Clinical investigation of atypical adenomatous hyperplasia of the lung.
Takigawa N, Segawa Y, Nakata M, Saeki H, Mandai K, Kishino D, Shimono M, Ida M, Eguchi K
Lung Cancer 1999 Aug;25(2):115-21. doi: 10.1016/s0169-5002(99)00055-0. PMID: 10470845

Prognosis

Integrating machine learning and single-cell analysis to uncover lung adenocarcinoma progression and prognostic biomarkers.
Zhang P, Feng J, Rui M, Xie J, Zhang L, Zhang Z
J Cell Mol Med 2024 Jul;28(13):e18516. doi: 10.1111/jcmm.18516. PMID: 38958577Free PMC Article
Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma.
Nie M, Yao K, Zhu X, Chen N, Xiao N, Wang Y, Peng B, Yao L, Li P, Zhang P, Hu Z
Nat Commun 2021 Nov 10;12(1):6479. doi: 10.1038/s41467-021-26685-y. PMID: 34759281Free PMC Article
Interstitial lung abnormalities: prognostic stratification of subtle radiological findings.
Silva M, Milanese G, Sverzellati N
Curr Opin Pulm Med 2018 Sep;24(5):432-439. doi: 10.1097/MCP.0000000000000497. PMID: 29939864
Pulmonary preneoplasia.
Dacic S
Arch Pathol Lab Med 2008 Jul;132(7):1073-8. doi: 10.5858/2008-132-1073-PP. PMID: 18605763
Pathology of lung cancer.
Travis WD
Clin Chest Med 2002 Mar;23(1):65-81, viii. doi: 10.1016/s0272-5231(03)00061-3. PMID: 11901921

Clinical prediction guides

Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma.
Nie M, Yao K, Zhu X, Chen N, Xiao N, Wang Y, Peng B, Yao L, Li P, Zhang P, Hu Z
Nat Commun 2021 Nov 10;12(1):6479. doi: 10.1038/s41467-021-26685-y. PMID: 34759281Free PMC Article
Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas.
Hu X, Estecio MR, Chen R, Reuben A, Wang L, Fujimoto J, Carrot-Zhang J, McGranahan N, Ying L, Fukuoka J, Chow CW, Pham HHN, Godoy MCB, Carter BW, Behrens C, Zhang J, Antonoff MB, Sepesi B, Lu Y, Pass HI, Kadara H, Scheet P, Vaporciyan AA, Heymach JV, Wistuba II, Lee JJ, Futreal PA, Su D, Issa JJ, Zhang J
Nat Commun 2021 Jan 29;12(1):687. doi: 10.1038/s41467-021-20907-z. PMID: 33514726Free PMC Article
Genetic Alterations in Preinvasive Lung Synchronous Lesions.
Ahn S, Lim J, Park SY, Kim H, Kwon HJ, Han YB, Lee CT, Cho S, Chung JH
Cancer Res Treat 2020 Oct;52(4):1120-1134. Epub 2020 Jun 5 doi: 10.4143/crt.2020.307. PMID: 32599981Free PMC Article
Interstitial lung abnormalities: prognostic stratification of subtle radiological findings.
Silva M, Milanese G, Sverzellati N
Curr Opin Pulm Med 2018 Sep;24(5):432-439. doi: 10.1097/MCP.0000000000000497. PMID: 29939864
Precursors to pulmonary neoplasia.
Colby TV, Wistuba II, Gazdar A
Adv Anat Pathol 1998 Jul;5(4):205-15. doi: 10.1097/00125480-199807000-00001. PMID: 9859753

Recent systematic reviews

Diagnostic Difficulties With Atrophy, Atypical Adenomatous Hyperplasia, and Atypical Small Acinar Proliferation: A Systematic Review of Current Literature.
Kowalewski A, Szylberg Ł, Skórczewska A, Marszałek A
Clin Genitourin Cancer 2016 Oct;14(5):361-365. Epub 2016 Feb 23 doi: 10.1016/j.clgc.2016.02.003. PMID: 26992486

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