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Benign peripheral nerve granular cell tumor

MedGen UID:
272363
•Concept ID:
C1332530
•
Neoplastic Process
Synonyms: Benign Granular Cell Neoplasm of Peripheral Nerve; benign granular cell neoplasm of peripheral nerve; Benign Granular Cell Neoplasm of the Peripheral Nerve; benign granular cell neoplasm of the peripheral nerve; benign granular cell tumor of nerve; Benign Granular Cell Tumor of Peripheral Nerve; benign granular cell tumor of peripheral nerve; Benign Granular Cell Tumor of the Peripheral Nerve; benign granular cell tumor of the peripheral nerve; benign granular cell tumour of nerve; benign granular cell tumour of peripheral nerve; benign granular cell tumour of the peripheral nerve; Benign Peripheral Nerve Granular Cell Neoplasm; benign peripheral nerve granular cell neoplasm; Benign Peripheral Nerve Granular Cell Tumor; benign peripheral nerve granular cell tumor; nerve benign granular cell tumor; nerve benign granular cell tumour
 
Monarch Initiative: MONDO:0056805

Definition

A granular cell tumor that arises from a peripheral nerve and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign peripheral nerve granular cell tumor

Recent clinical studies

Etiology

Benign peripheral nerve tumors: Analysis of 89 FNA cases emphasizing diagnostic accuracy and their morphologic spectrum.
Wakely PE Jr
Cancer Cytopathol 2023 May;131(5):300-312. Epub 2023 Jan 17 doi: 10.1002/cncy.22680. PMID: 36650522
Primary Brachial Plexus Tumors: Clinical Experiences of 143 Cases.
Jia X, Yang J, Chen L, Yu C, Kondo T
Clin Neurol Neurosurg 2016 Sep;148:91-5. Epub 2016 Jul 4 doi: 10.1016/j.clineuro.2016.07.009. PMID: 27428490
Fine-needle aspiration of soft tissue perineurioma: A comparative analysis of cytomorphology and immunohistochemistry with benign and malignant mimics.
Yang EJ, Hornick JL, Qian X
Cancer Cytopathol 2016 Sep;124(9):651-8. Epub 2016 May 9 doi: 10.1002/cncy.21725. PMID: 27159449
Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: a case report and review of literature.
Policarpio-Nicolas ML, Abbott TE, Dalkin AC, Bennett-Wick J, Frierson HF Jr
Diagn Cytopathol 2008 Feb;36(2):115-9. doi: 10.1002/dc.20772. PMID: 18181193
Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation.
Blacksin MF, White LM, Hameed M, Kandel R, Patterson FR, Benevenia J
Skeletal Radiol 2005 Oct;34(10):625-31. Epub 2005 Jul 8 doi: 10.1007/s00256-005-0925-8. PMID: 16003548

Diagnosis

PRAME immunohistochemistry in soft tissue tumors and mimics: a study of 350 cases highlighting its imperfect specificity but potentially useful diagnostic applications.
Cammareri C, Beltzung F, Michal M, Vanhersecke L, Coindre JM, Velasco V, Le Loarer F, Vergier B, Perret R
Virchows Arch 2023 Aug;483(2):145-156. Epub 2023 Jul 21 doi: 10.1007/s00428-023-03606-6. PMID: 37477762
Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Ischiorectal fossa: benign and malignant neoplasms of this "ignored" radiological anatomical space.
Faria SC, Elsherif SB, Sagebiel T, Cox V, Rao B, Lall C, Bhosale PR
Abdom Radiol (NY) 2019 May;44(5):1644-1674. doi: 10.1007/s00261-019-01930-7. PMID: 30955068
Peripheral nerve sheath tumors of the breast.
Charu V, Cimino-Mathews A
Semin Diagn Pathol 2017 Sep;34(5):420-426. Epub 2017 May 27 doi: 10.1053/j.semdp.2017.05.011. PMID: 28647116
Unexpected granular cell tumor in abdominal wall: case report and literature review.
Panunzi A, D'Orazi V, Toni F, Coppola GA, D'Alessandro V, Pontone S, Pironi D, Ortensi A
Tumori 2012 Jan-Feb;98(1):e18-21. doi: 10.1177/030089161209800132. PMID: 22495725

Therapy

Granular cell traumatic neuroma: a lesion occurring in mastectomy scars.
Rosso R, Scelsi M, Carnevali L
Arch Pathol Lab Med 2000 May;124(5):709-11. doi: 10.5858/2000-124-0709-GCTN. PMID: 10782152

Prognosis

Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Granular cell tumor in a child: A rare case report.
Yilmaz ZS, Ersoz S
Indian J Pathol Microbiol 2020 Jul-Sep;63(3):478-480. doi: 10.4103/IJPM.IJPM_495_19. PMID: 32769346
Peripheral nerve sheath tumors of the breast.
Charu V, Cimino-Mathews A
Semin Diagn Pathol 2017 Sep;34(5):420-426. Epub 2017 May 27 doi: 10.1053/j.semdp.2017.05.011. PMID: 28647116
Primary Brachial Plexus Tumors: Clinical Experiences of 143 Cases.
Jia X, Yang J, Chen L, Yu C, Kondo T
Clin Neurol Neurosurg 2016 Sep;148:91-5. Epub 2016 Jul 4 doi: 10.1016/j.clineuro.2016.07.009. PMID: 27428490
Mediastinal tumors of peripheral nervous system origin.
Marchevsky AM
Semin Diagn Pathol 1999 Feb;16(1):65-78. PMID: 10355655

Clinical prediction guides

Immunoexpression of BDNF, TrkB, and p75NTR receptors in peripheral neural lesions of the head and neck.
Ribeiro JT, Thieme S, Zettermann P, Leite AA, Zanella VG, Pilar EFS, Fonseca FP, Mesquita RA, Vargas PA, Dos Santos JN, Martins MD
J Oral Pathol Med 2021 May;50(5):492-501. Epub 2020 Dec 30 doi: 10.1111/jop.13145. PMID: 33222311
Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Peripheral nerve sheath tumors of the breast.
Charu V, Cimino-Mathews A
Semin Diagn Pathol 2017 Sep;34(5):420-426. Epub 2017 May 27 doi: 10.1053/j.semdp.2017.05.011. PMID: 28647116
Benign gastrointestinal mesenchymal BUMPS: a brief review of some spindle cell polyps with published names.
Rittershaus AC, Appelman HD
Arch Pathol Lab Med 2011 Oct;135(10):1311-9. doi: 10.5858/arpa.2011-0038-RA. PMID: 21970486
Malignant granular cell tumor of the radial nerve: an autopsy observation with electron microscopic and tissue culture studies.
Usui M, Ishii S, Yamawaki S, Sasaki T, Minami A
Cancer 1977 Apr;39(4):1547-55. doi: 10.1002/1097-0142(197704)39:4<1547::aid-cncr2820390428>3.0.co;2-o. PMID: 856443

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