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Chronic eosinophilic pneumonia

MedGen UID:
3085
Concept ID:
C0008680
Disease or Syndrome
Synonyms: Chronic Eosinophilic Pneumonia; chronic eosinophilic pneumonia; Chronic pulmonary eosinophilia; Cryptogenic eosinophilic pneumonia; Cryptogenic pulmonary eosinophilia; cryptogenic pulmonary eosinophilia; eosinophilic pneumonia, chronic; Idiopathic pulmonary eosinophilia
SNOMED CT: Cryptogenic pulmonary eosinophilia (233692000); Cryptogenic eosinophilic pneumonia (233692000); Chronic eosinophilic pneumonia (233692000); Chronic pulmonary eosinophilia (233692000); Idiopathic pulmonary eosinophilia (233692000)
 
Monarch Initiative: MONDO:0004806

Definition

Chronic inflammatory disorder of the lungs characterized by the presence of eosinophils in the interalveolar septa and alveolar spaces and peripheral blood eosinophilia. Chest x-rays reveal peripheral infiltrates. Approximately half of the patients have history of asthma or atopic disease. Signs and symptoms include fever, dyspnea, cough, and weight loss. Following treatment with corticosteroids, the eosinophilic infiltrates in the lungs disappear, resulting in dramatic clinical improvement. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Asano K, Hebisawa A, Ishiguro T, Takayanagi N, Nakamura Y, Suzuki J, Okada N, Tanaka J, Fukutomi Y, Ueki S, Fukunaga K, Konno S, Matsuse H, Kamei K, Taniguchi M, Shimoda T, Oguma T; Japan ABPM Research Program
J Allergy Clin Immunol 2021 Apr;147(4):1261-1268.e5. Epub 2020 Sep 10 doi: 10.1016/j.jaci.2020.08.029. PMID: 32920094
Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537
Giovannini-Chami L, Blanc S, Hadchouel A, Baruchel A, Boukari R, Dubus JC, Fayon M, Le Bourgeois M, Nathan N, Albertini M, Clément A, de Blic J
Pediatr Pulmonol 2016 Feb;51(2):203-16. Epub 2015 Dec 30 doi: 10.1002/ppul.23368. PMID: 26716396

Recent clinical studies

Etiology

Asano K, Hebisawa A, Ishiguro T, Takayanagi N, Nakamura Y, Suzuki J, Okada N, Tanaka J, Fukutomi Y, Ueki S, Fukunaga K, Konno S, Matsuse H, Kamei K, Taniguchi M, Shimoda T, Oguma T; Japan ABPM Research Program
J Allergy Clin Immunol 2021 Apr;147(4):1261-1268.e5. Epub 2020 Sep 10 doi: 10.1016/j.jaci.2020.08.029. PMID: 32920094
Allen J, Wert M
J Allergy Clin Immunol Pract 2018 Sep-Oct;6(5):1455-1461. Epub 2018 May 4 doi: 10.1016/j.jaip.2018.03.011. PMID: 29735405
Campos LE, Pereira LF
J Bras Pneumol 2009 Jun;35(6):561-73. doi: 10.1590/s1806-37132009000600010. PMID: 19618037
Marchand E, Cordier JF
Orphanet J Rare Dis 2006 Apr 6;1:11. doi: 10.1186/1750-1172-1-11. PMID: 16722612Free PMC Article
DePaso WJ, Winterbauer RH
Dis Mon 1991 Feb;37(2):61-133. PMID: 1991445

Diagnosis

Cottin V
Immunol Allergy Clin North Am 2023 May;43(2):289-322. doi: 10.1016/j.iac.2023.01.002. PMID: 37055090
Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537
Allen J, Wert M
J Allergy Clin Immunol Pract 2018 Sep-Oct;6(5):1455-1461. Epub 2018 May 4 doi: 10.1016/j.jaip.2018.03.011. PMID: 29735405
Campos LE, Pereira LF
J Bras Pneumol 2009 Jun;35(6):561-73. doi: 10.1590/s1806-37132009000600010. PMID: 19618037
Katz U, Shoenfeld Y
Clin Rev Allergy Immunol 2008 Jun;34(3):367-71. doi: 10.1007/s12016-007-8053-y. PMID: 18197481

Therapy

Muñoz-Bellido FJ, Moreno E, Dávila I
J Investig Allergol Clin Immunol 2022 Apr 19;32(2):97-115. Epub 2021 Mar 3 doi: 10.18176/jiaci.0682. PMID: 33661102
Allen J, Wert M
J Allergy Clin Immunol Pract 2018 Sep-Oct;6(5):1455-1461. Epub 2018 May 4 doi: 10.1016/j.jaip.2018.03.011. PMID: 29735405
Rose DM, Hrncir DE
Allergy Asthma Proc 2013 Jan-Feb;34(1):19-25. doi: 10.2500/aap.2013.34.3628. PMID: 23406932
Katz U, Shoenfeld Y
Clin Rev Allergy Immunol 2008 Jun;34(3):367-71. doi: 10.1007/s12016-007-8053-y. PMID: 18197481
Carrington CB, Addington WW, Goff AM, Madoff IM, Marks A, Schwaber JR, Gaensler EA
N Engl J Med 1969 Apr 10;280(15):787-98. doi: 10.1056/NEJM196904102801501. PMID: 5773637

Prognosis

Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537
Allen J, Wert M
J Allergy Clin Immunol Pract 2018 Sep-Oct;6(5):1455-1461. Epub 2018 May 4 doi: 10.1016/j.jaip.2018.03.011. PMID: 29735405
Katz U, Shoenfeld Y
Clin Rev Allergy Immunol 2008 Jun;34(3):367-71. doi: 10.1007/s12016-007-8053-y. PMID: 18197481
Marchand E, Cordier JF
Orphanet J Rare Dis 2006 Apr 6;1:11. doi: 10.1186/1750-1172-1-11. PMID: 16722612Free PMC Article

Clinical prediction guides

Murillo AD, Castrillon AI, Serrano CD, Fernandez-Trujillo L
BMC Pulm Med 2024 Feb 8;24(1):74. doi: 10.1186/s12890-024-02868-3. PMID: 38331769Free PMC Article
Brenard E, Pilette C, Dahlqvist C, Colinet B, Schleich F, Roufosse F, Froidure A
Lung 2020 Apr;198(2):355-360. Epub 2020 Feb 12 doi: 10.1007/s00408-020-00336-3. PMID: 32052155
Ishiguro T, Takayanagi N, Uozumi R, Tada M, Kagiyama N, Takaku Y, Shimizu Y, Sugita Y, Morita S
Intern Med 2016;55(17):2373-7. Epub 2016 Sep 1 doi: 10.2169/internalmedicine.55.6765. PMID: 27580536
Matsuda Y, Tachibana K, Sasaki Y, Tsuyuguchi K, Kitaichi M, Inoue Y
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Mochimaru H, Kawamoto M, Fukuda Y, Kudoh S
Respirology 2005 Jan;10(1):76-85. doi: 10.1111/j.1440-1843.2005.00648.x. PMID: 15691242

Recent systematic reviews

Hochhegger B, Zanon M, Altmayer S, Mandelli NS, Stüker G, Mohammed TL, Verma N, Meirelles GSP, Marchiori E
Br J Radiol 2021 Feb 1;94(1118):20200703. Epub 2020 Dec 9 doi: 10.1259/bjr.20200703. PMID: 33296607Free PMC Article

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