U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Constitutional symptom

MedGen UID:
3593
•Concept ID:
C0009812
•
Sign or Symptom
Synonyms: Constitutional Finding; Constitutional Symptom
 
HPO: HP:0025142

Definition

A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConstitutional symptom

Professional guidelines

PubMed

Novel agents for the treatment of polycythemia vera: an insight into preclinical research and early phase clinical trials.
Padrnos L, Mesa R
Expert Opin Investig Drugs 2020 Aug;29(8):809-817. Epub 2020 Jul 16 doi: 10.1080/13543784.2020.1782886. PMID: 32552220Free PMC Article
Impact of influenza treatment with oseltamivir on health, sleep and daily activities of otherwise healthy adults and adolescents.
Bettis R, Iacuzio D, Jung T, Fuchs R, Aultman R, Gyldmark M
Clin Drug Investig 2006;26(6):329-40. doi: 10.2165/00044011-200626060-00004. PMID: 17163267

Recent clinical studies

Etiology

Diagnosis and Therapy of Infectious Encephalitis in Children: A Ten-Years Retrospective Study.
Pata D, Buonsenso D, Frasca G, Lazzareschi I, Salerno G, Turriziani Colonna A, Mariotti P, Valentini P
Pediatr Infect Dis J 2021 Jun 1;40(6):513-517. doi: 10.1097/INF.0000000000003070. PMID: 33902074
Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants.
Mulazzani E, Wagner D, Havla J, Schlüter M, Meinl I, Gerdes LA, Kümpfel T
J Neuroinflammation 2020 Jun 20;17(1):196. doi: 10.1186/s12974-020-01867-5. PMID: 32563262Free PMC Article
Novel agents for the treatment of polycythemia vera: an insight into preclinical research and early phase clinical trials.
Padrnos L, Mesa R
Expert Opin Investig Drugs 2020 Aug;29(8):809-817. Epub 2020 Jul 16 doi: 10.1080/13543784.2020.1782886. PMID: 32552220Free PMC Article
Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT.
McLornan DP, Malpassuti V, Lippinkhof-Kozijn A, Potter V, Beelen D, Bunjes D, Sengeloev H, Radujkovic A, Passweg J, Chalandon Y, Kröger N, Wulf GG, Johansson JE, Ciceri F, Bornhäuser M, Holler E, Guffroy B, Martin S, Neubauer A, Gramatski M, Robin M, Iacobelli S, Hayden P, Hernández Boluda JC, Czerw T, Yakoub-Agha I
Br J Haematol 2020 Aug;190(3):437-441. Epub 2020 Feb 28 doi: 10.1111/bjh.16537. PMID: 32108327
Acute respiratory infection and influenza-like illness viral etiologies in Brazilian adults.
Bellei N, Carraro E, Perosa A, Watanabe A, Arruda E, Granato C
J Med Virol 2008 Oct;80(10):1824-7. doi: 10.1002/jmv.21295. PMID: 18712837Free PMC Article

Diagnosis

Differences between aquagenic and non-aquagenic pruritus in myeloproliferative neoplasms: An observational study of 500 patients.
Le Gall-Ianotto C, Ficheux AS, Lippert E, Herbreteau L, Rio L, Pan-Petesch B, Misery L, Ianotto JC
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1175-1183. Epub 2023 Mar 9 doi: 10.1111/jdv.18990. PMID: 36808754
Development and validation of a simple risk score for diagnosing COVID-19 in the emergency room.
Sung J, Choudry N, Bachour R
Epidemiol Infect 2020 Nov 13;148:e273. doi: 10.1017/S0950268820002769. PMID: 33183384Free PMC Article
Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective.
Seynaeve D, Augusseau-Rivière B, Couturier P, Morel-Baccard C, Landelle C, Bosson JL, Gavazzi G, Mallaret MR
J Am Med Dir Assoc 2020 Jan;21(1):104-109.e1. Epub 2019 May 14 doi: 10.1016/j.jamda.2019.03.015. PMID: 31101588Free PMC Article
Workplace Indirect Cost Impacts of Nasal and Sinus Symptoms and Related Conditions.
Kuiper JR, Hirsch AG, Bandeen-Roche K, Sundaresan AS, Tan BK, Kern RC, Schleimer RP, Schwartz BS
J Occup Environ Med 2019 Aug;61(8):e333-e339. doi: 10.1097/JOM.0000000000001636. PMID: 31205204Free PMC Article
Acute respiratory infection and influenza-like illness viral etiologies in Brazilian adults.
Bellei N, Carraro E, Perosa A, Watanabe A, Arruda E, Granato C
J Med Virol 2008 Oct;80(10):1824-7. doi: 10.1002/jmv.21295. PMID: 18712837Free PMC Article

Therapy

Differences between aquagenic and non-aquagenic pruritus in myeloproliferative neoplasms: An observational study of 500 patients.
Le Gall-Ianotto C, Ficheux AS, Lippert E, Herbreteau L, Rio L, Pan-Petesch B, Misery L, Ianotto JC
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1175-1183. Epub 2023 Mar 9 doi: 10.1111/jdv.18990. PMID: 36808754
Novel agents for the treatment of polycythemia vera: an insight into preclinical research and early phase clinical trials.
Padrnos L, Mesa R
Expert Opin Investig Drugs 2020 Aug;29(8):809-817. Epub 2020 Jul 16 doi: 10.1080/13543784.2020.1782886. PMID: 32552220Free PMC Article
Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial.
Haffizulla J, Hartman A, Hoppers M, Resnick H, Samudrala S, Ginocchio C, Bardin M, Rossignol JF; US Nitazoxanide Influenza Clinical Study Group
Lancet Infect Dis 2014 Jul;14(7):609-18. Epub 2014 May 19 doi: 10.1016/S1473-3099(14)70717-0. PMID: 24852376Free PMC Article
Serum proinflammatory cytokine response in patients with advanced liver tumors following selective internal radiation therapy (SIRT) with (90)Yttrium microspheres.
Wickremesekera JK, Chen W, Cannan RJ, Stubbs RS
Int J Radiat Oncol Biol Phys 2001 Mar 15;49(4):1015-21. doi: 10.1016/s0360-3016(00)01420-6. PMID: 11240242
Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study Group.
Treanor JJ, Hayden FG, Vrooman PS, Barbarash R, Bettis R, Riff D, Singh S, Kinnersley N, Ward P, Mills RG
JAMA 2000 Feb 23;283(8):1016-24. doi: 10.1001/jama.283.8.1016. PMID: 10697061

Prognosis

Diagnosis and Therapy of Infectious Encephalitis in Children: A Ten-Years Retrospective Study.
Pata D, Buonsenso D, Frasca G, Lazzareschi I, Salerno G, Turriziani Colonna A, Mariotti P, Valentini P
Pediatr Infect Dis J 2021 Jun 1;40(6):513-517. doi: 10.1097/INF.0000000000003070. PMID: 33902074
Development and validation of a simple risk score for diagnosing COVID-19 in the emergency room.
Sung J, Choudry N, Bachour R
Epidemiol Infect 2020 Nov 13;148:e273. doi: 10.1017/S0950268820002769. PMID: 33183384Free PMC Article
Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants.
Mulazzani E, Wagner D, Havla J, Schlüter M, Meinl I, Gerdes LA, Kümpfel T
J Neuroinflammation 2020 Jun 20;17(1):196. doi: 10.1186/s12974-020-01867-5. PMID: 32563262Free PMC Article
Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT.
McLornan DP, Malpassuti V, Lippinkhof-Kozijn A, Potter V, Beelen D, Bunjes D, Sengeloev H, Radujkovic A, Passweg J, Chalandon Y, Kröger N, Wulf GG, Johansson JE, Ciceri F, Bornhäuser M, Holler E, Guffroy B, Martin S, Neubauer A, Gramatski M, Robin M, Iacobelli S, Hayden P, Hernández Boluda JC, Czerw T, Yakoub-Agha I
Br J Haematol 2020 Aug;190(3):437-441. Epub 2020 Feb 28 doi: 10.1111/bjh.16537. PMID: 32108327
Acute respiratory infection and influenza-like illness viral etiologies in Brazilian adults.
Bellei N, Carraro E, Perosa A, Watanabe A, Arruda E, Granato C
J Med Virol 2008 Oct;80(10):1824-7. doi: 10.1002/jmv.21295. PMID: 18712837Free PMC Article

Clinical prediction guides

Differences between aquagenic and non-aquagenic pruritus in myeloproliferative neoplasms: An observational study of 500 patients.
Le Gall-Ianotto C, Ficheux AS, Lippert E, Herbreteau L, Rio L, Pan-Petesch B, Misery L, Ianotto JC
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1175-1183. Epub 2023 Mar 9 doi: 10.1111/jdv.18990. PMID: 36808754
Development and validation of a simple risk score for diagnosing COVID-19 in the emergency room.
Sung J, Choudry N, Bachour R
Epidemiol Infect 2020 Nov 13;148:e273. doi: 10.1017/S0950268820002769. PMID: 33183384Free PMC Article
Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective.
Seynaeve D, Augusseau-Rivière B, Couturier P, Morel-Baccard C, Landelle C, Bosson JL, Gavazzi G, Mallaret MR
J Am Med Dir Assoc 2020 Jan;21(1):104-109.e1. Epub 2019 May 14 doi: 10.1016/j.jamda.2019.03.015. PMID: 31101588Free PMC Article
Workplace Indirect Cost Impacts of Nasal and Sinus Symptoms and Related Conditions.
Kuiper JR, Hirsch AG, Bandeen-Roche K, Sundaresan AS, Tan BK, Kern RC, Schleimer RP, Schwartz BS
J Occup Environ Med 2019 Aug;61(8):e333-e339. doi: 10.1097/JOM.0000000000001636. PMID: 31205204Free PMC Article
Acute respiratory infection and influenza-like illness viral etiologies in Brazilian adults.
Bellei N, Carraro E, Perosa A, Watanabe A, Arruda E, Granato C
J Med Virol 2008 Oct;80(10):1824-7. doi: 10.1002/jmv.21295. PMID: 18712837Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...