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Lithium Induced Birth Defect

MedGen UID:
476131
•Concept ID:
C3274498
•
Congenital Abnormality

Definition

Congenital abnormalities, mainly cardiovascular malformations, which develop in a fetus when the mother uses lithium medication during pregnancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLithium Induced Birth Defect

Professional guidelines

PubMed

Weighing the Risks: the Management of Bipolar Disorder During Pregnancy.
Thomson M, Sharma V
Curr Psychiatry Rep 2018 Mar 17;20(3):20. doi: 10.1007/s11920-018-0882-2. PMID: 29549608
Optimizing lithium treatment.
Dunner DL
J Clin Psychiatry 2000;61 Suppl 9:76-81. PMID: 10826665
Lithium treatment during pregnancy, delivery, and lactation: an update.
Schou M
J Clin Psychiatry 1990 Oct;51(10):410-3. PMID: 2211538

Recent clinical studies

Etiology

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes.
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Psychotropics in pregnancy: safety and other considerations.
Oyebode F, Rastogi A, Berrisford G, Coccia F
Pharmacol Ther 2012 Jul;135(1):71-7. Epub 2012 Mar 28 doi: 10.1016/j.pharmthera.2012.03.008. PMID: 22483705
Lithium treatment during pregnancy, delivery, and lactation: an update.
Schou M
J Clin Psychiatry 1990 Oct;51(10):410-3. PMID: 2211538
Maternal drugs and congenital heart disease.
Zierler S
Obstet Gynecol 1985 Feb;65(2):155-65. PMID: 3881709
Lithium and pregnancy.
Pitts FN
J Clin Psychiatry 1983 Oct;44(10):357. PMID: 6643395

Diagnosis

When lithium hurts: a look at Ebstein anomaly.
Osiro S, Tiwari KJ, Mathenge N, Rodriguez JR, Tubbs RS, Loukas M
Cardiol Rev 2013 Sep-Oct;21(5):257-63. doi: 10.1097/CRD.0b013e318280c966. PMID: 23269033
Drug exposure in pregnancy and heart defects.
Matok I, Pupco A, Koren G
J Cardiovasc Pharmacol 2011 Jul;58(1):20-4. doi: 10.1097/FJC.0b013e31821c471b. PMID: 21499119
Lithium efficacy and adverse effects.
Gelenberg AJ
J Clin Psychiatry 1988 Nov;49 Suppl:8-11. PMID: 3053673
Maternal drugs and congenital heart disease.
Zierler S
Obstet Gynecol 1985 Feb;65(2):155-65. PMID: 3881709
Lithium and pregnancy. A cohort study on manic-depressive women.
Källén B, Tandberg A
Acta Psychiatr Scand 1983 Aug;68(2):134-9. doi: 10.1111/j.1600-0447.1983.tb06991.x. PMID: 6624510

Therapy

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes.
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Optimizing lithium treatment.
Dunner DL
J Clin Psychiatry 2000;61 Suppl 9:76-81. PMID: 10826665
Lithium efficacy and adverse effects.
Gelenberg AJ
J Clin Psychiatry 1988 Nov;49 Suppl:8-11. PMID: 3053673
Lithium adverse reactions in psychiatric patients.
Paragas MG
Pharmacol Biochem Behav 1984;21 Suppl 1:65-9. doi: 10.1016/0091-3057(84)90165-5. PMID: 6151673
Lithium and pregnancy.
Pitts FN
J Clin Psychiatry 1983 Oct;44(10):357. PMID: 6643395

Prognosis

When should we prescribe high-dose folic acid to prevent congenital heart defects?
Huhta JC, Linask K
Curr Opin Cardiol 2015 Jan;30(1):125-31. doi: 10.1097/HCO.0000000000000124. PMID: 25389654
When lithium hurts: a look at Ebstein anomaly.
Osiro S, Tiwari KJ, Mathenge N, Rodriguez JR, Tubbs RS, Loukas M
Cardiol Rev 2013 Sep-Oct;21(5):257-63. doi: 10.1097/CRD.0b013e318280c966. PMID: 23269033
QT alterations in psychopharmacology: proven candidates and suspects.
Alvarez PA, Pahissa J
Curr Drug Saf 2010 Jan;5(1):97-104. doi: 10.2174/157488610789869265. PMID: 20210726
Teratogenesis associated with antibipolar agents.
Nguyen HT, Sharma V, McIntyre RS
Adv Ther 2009 Mar;26(3):281-94. Epub 2009 Mar 28 doi: 10.1007/s12325-009-0011-z. PMID: 19330496
Lithium and pregnancy. A cohort study on manic-depressive women.
Källén B, Tandberg A
Acta Psychiatr Scand 1983 Aug;68(2):134-9. doi: 10.1111/j.1600-0447.1983.tb06991.x. PMID: 6624510

Clinical prediction guides

When should we prescribe high-dose folic acid to prevent congenital heart defects?
Huhta JC, Linask K
Curr Opin Cardiol 2015 Jan;30(1):125-31. doi: 10.1097/HCO.0000000000000124. PMID: 25389654
QT alterations in psychopharmacology: proven candidates and suspects.
Alvarez PA, Pahissa J
Curr Drug Saf 2010 Jan;5(1):97-104. doi: 10.2174/157488610789869265. PMID: 20210726
Teratogenesis associated with antibipolar agents.
Nguyen HT, Sharma V, McIntyre RS
Adv Ther 2009 Mar;26(3):281-94. Epub 2009 Mar 28 doi: 10.1007/s12325-009-0011-z. PMID: 19330496
The use of psychiatric drugs in pregnancy and lactation.
Arnon J, Shechtman S, Ornoy A
Isr J Psychiatry Relat Sci 2000;37(3):205-22. PMID: 11084808
A reevaluation of risk of in utero exposure to lithium.
Cohen LS, Friedman JM, Jefferson JW, Johnson EM, Weiner ML
JAMA 1994 Jan 12;271(2):146-50. PMID: 8031346

Recent systematic reviews

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes.
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Psychotropics in pregnancy: safety and other considerations.
Oyebode F, Rastogi A, Berrisford G, Coccia F
Pharmacol Ther 2012 Jul;135(1):71-7. Epub 2012 Mar 28 doi: 10.1016/j.pharmthera.2012.03.008. PMID: 22483705
Mood stabilizers in pregnancy: a systematic review.
Galbally M, Roberts M, Buist A; Perinatal Psychotropic Review Group
Aust N Z J Psychiatry 2010 Nov;44(11):967-77. doi: 10.3109/00048674.2010.506637. PMID: 21034180

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