U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hyaline membrane disease

MedGen UID:
5656
•Concept ID:
C0020192
•
Disease or Syndrome
Synonyms: Disease, Hyaline Membrane; Diseases, Hyaline Membrane; Hyaline Membrane Disease; Hyaline Membrane Diseases
SNOMED CT: HMD - Hyaline membrane disease (46775006); Hyaline membrane disease (46775006)

Definition

A respiratory distress syndrome in newborn infants, usually premature infants with insufficient PULMONARY SURFACTANTS. The disease is characterized by the formation of a HYALINE-like membrane lining the terminal respiratory airspaces (PULMONARY ALVEOLI) and subsequent collapse of the lung (PULMONARY ATELECTASIS). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyaline membrane disease

Professional guidelines

PubMed

Extrauterine growth restriction in very preterm infant: etiology, diagnosis, and 2-year follow-up.
Figueras-Aloy J, Palet-Trujols C, Matas-Barceló I, Botet-Mussons F, Carbonell-Estrany X
Eur J Pediatr 2020 Sep;179(9):1469-1479. Epub 2020 Mar 19 doi: 10.1007/s00431-020-03628-1. PMID: 32193657
European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update.
Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Te Pas A, Plavka R, Roehr CC, Saugstad OD, Simeoni U, Speer CP, Vento M, Visser GHA, Halliday HL
Neonatology 2019;115(4):432-450. Epub 2019 Apr 11 doi: 10.1159/000499361. PMID: 30974433Free PMC Article
Ambroxol for prevention and treatment of hyaline membrane disease.
Wauer RR, Schmalisch G, Hammer H, Buttenberg S, Weigel H, Huth M
Eur Respir J Suppl 1989 Mar;3:57S-65S. PMID: 2662997

Recent clinical studies

Etiology

The burden of hyaline membrane disease, mortality and its determinant factors among preterm neonates admitted at Debre Tabor General Hospital, North Central Ethiopia: A retrospective follow up study.
Minuye Birihane B, Alebachew Bayih W, Yeshambel Alemu A, Belay DM, Demis A
PLoS One 2021;16(3):e0249365. Epub 2021 Mar 30 doi: 10.1371/journal.pone.0249365. PMID: 33784349Free PMC Article
Hyaline membrane disease and surfactant protein, SAP-35, in diabetes in pregnancy.
Nogee L, McMahan M, Whitsett JA
Am J Perinatol 1988 Oct;5(4):374-7. doi: 10.1055/s-2007-999725. PMID: 3048286
The prevention of hyaline membrane disease: new concepts and approaches to therapy.
Farrell PM, Kotas RV
Adv Pediatr 1976;23:213-69. PMID: 795280
Hyaline membrane disease.
Farrell PM, Avery ME
Am Rev Respir Dis 1975 May;111(5):657-88. doi: 10.1164/arrd.1975.111.5.657. PMID: 1093459
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
Northway WH Jr, Rosan RC, Porter DY
N Engl J Med 1967 Feb 16;276(7):357-68. doi: 10.1056/NEJM196702162760701. PMID: 5334613

Diagnosis

Intrathoracic kidney.
Ramos AJ, Slovis TL, Reed JO
Urology 1979 Jan;13(1):14-9. doi: 10.1016/0090-4295(79)90005-0. PMID: 442315
Hyaline membrane disease.
Vidyasagar D, Bhat R
Obstet Gynecol Annu 1977;6:223-45. PMID: 22056
Neonatal pneumopericardium.
Brans YW, Pitts M, Cassady G
Am J Dis Child 1976 Apr;130(4):393-6. doi: 10.1001/archpedi.1976.02120050051009. PMID: 773172
Hyaline membrane disease.
Farrell PM, Avery ME
Am Rev Respir Dis 1975 May;111(5):657-88. doi: 10.1164/arrd.1975.111.5.657. PMID: 1093459
Hyaline membrane disease.
Reynolds EO
Am J Obstet Gynecol 1970 Mar;106(5):780-97. doi: 10.1016/0002-9378(70)90406-0. PMID: 4984152

Therapy

Hyaline membrane disease (HMD): an historical and Oslerian perspective.
Malloy MH, McGovern JP
J Perinatol 2018 Dec;38(12):1602-1606. Epub 2018 Oct 5 doi: 10.1038/s41372-018-0237-1. PMID: 30291319
Pulmonary surfactant therapy.
Poulain FR, Clements JA
West J Med 1995 Jan;162(1):43-50. PMID: 7863656Free PMC Article
Hyaline membrane disease.
Farrell PM, Avery ME
Am Rev Respir Dis 1975 May;111(5):657-88. doi: 10.1164/arrd.1975.111.5.657. PMID: 1093459
Surfactant.
Woolcock AJ
Med J Aust 1973 May 5;1(18):900-3. doi: 10.5694/j.1326-5377.1973.tb110777.x. PMID: 4577314
Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
Northway WH Jr, Rosan RC, Porter DY
N Engl J Med 1967 Feb 16;276(7):357-68. doi: 10.1056/NEJM196702162760701. PMID: 5334613

Prognosis

Historical perspective on surfactant therapy: Transforming hyaline membrane disease to respiratory distress syndrome.
Hallman M, Herting E
Semin Fetal Neonatal Med 2023 Dec;28(6):101493. Epub 2023 Nov 22 doi: 10.1016/j.siny.2023.101493. PMID: 38030434
Hyaline membrane disease (HMD): an historical and Oslerian perspective.
Malloy MH, McGovern JP
J Perinatol 2018 Dec;38(12):1602-1606. Epub 2018 Oct 5 doi: 10.1038/s41372-018-0237-1. PMID: 30291319
Neonatal pneumopericardium.
Burt TB, Lester PD
Radiology 1982 Jan;142(1):81-4. doi: 10.1148/radiology.142.1.7053553. PMID: 7053553
The prevention of hyaline membrane disease: new concepts and approaches to therapy.
Farrell PM, Kotas RV
Adv Pediatr 1976;23:213-69. PMID: 795280
Hyaline membrane disease.
Farrell PM, Avery ME
Am Rev Respir Dis 1975 May;111(5):657-88. doi: 10.1164/arrd.1975.111.5.657. PMID: 1093459

Clinical prediction guides

Historical perspective on surfactant therapy: Transforming hyaline membrane disease to respiratory distress syndrome.
Hallman M, Herting E
Semin Fetal Neonatal Med 2023 Dec;28(6):101493. Epub 2023 Nov 22 doi: 10.1016/j.siny.2023.101493. PMID: 38030434
European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update.
Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Te Pas A, Plavka R, Roehr CC, Saugstad OD, Simeoni U, Speer CP, Vento M, Visser GHA, Halliday HL
Neonatology 2019;115(4):432-450. Epub 2019 Apr 11 doi: 10.1159/000499361. PMID: 30974433Free PMC Article
Neonatal mechanical ventilation.
Riyas PK, Vijayakumar KM, Kulkarni ML
Indian J Pediatr 2003 Jul;70(7):537-40. doi: 10.1007/BF02723151. PMID: 12940373
Neonatal pneumopericardium.
Brans YW, Pitts M, Cassady G
Am J Dis Child 1976 Apr;130(4):393-6. doi: 10.1001/archpedi.1976.02120050051009. PMID: 773172
Hyaline membrane disease.
Farrell PM, Avery ME
Am Rev Respir Dis 1975 May;111(5):657-88. doi: 10.1164/arrd.1975.111.5.657. PMID: 1093459

Recent systematic reviews

Use of budesonide associated with a pulmonary surfactant to prevent bronchopulmonary dysplasia in premature newborns - A systematic review.
Moraes LHA, Coelho RMD, Neves Dos Santos Beozzo GP, Yoshida RAM, de Albuquerque Diniz EM, de Carvalho WB
J Pediatr (Rio J) 2023 Mar-Apr;99(2):105-111. Epub 2022 Nov 25 doi: 10.1016/j.jped.2022.10.007. PMID: 36436670Free PMC Article
Expectant Versus Interventionist Care in the Management of Severe Preeclampsia Remote from Term: A Systematic Review.
Quintero-Ortíz MA, Grillo-Ardila CF, Amaya-Guio J
Rev Bras Ginecol Obstet 2021 Aug;43(8):627-637. Epub 2021 Sep 21 doi: 10.1055/s-0041-1733999. PMID: 34547798Free PMC Article
Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation.
Churchill D, Duley L, Thornton JG, Jones L
Cochrane Database Syst Rev 2013 Jul 26;(7):CD003106. doi: 10.1002/14651858.CD003106.pub2. PMID: 23888485
Long versus short inspiratory times in neonates receiving mechanical ventilation.
Kamlin C, Davis PG
Cochrane Database Syst Rev 2004 Oct 18;2003(4):CD004503. doi: 10.1002/14651858.CD004503.pub2. PMID: 15495117Free PMC Article
Interventionist versus expectant care for severe pre-eclampsia before term.
Churchill D, Duley L
Cochrane Database Syst Rev 2002;(3):CD003106. doi: 10.1002/14651858.CD003106. PMID: 12137674

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...