From HPO
Asthenia- MedGen UID:
- 2107
- •Concept ID:
- C0004093
- •
- Sign or Symptom
A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body.
Fatigue- MedGen UID:
- 41971
- •Concept ID:
- C0015672
- •
- Sign or Symptom
A subjective feeling of tiredness characterized by a lack of energy and motivation.
Gangrene- MedGen UID:
- 6546
- •Concept ID:
- C0017086
- •
- Disease or Syndrome
A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis).
Myalgia- MedGen UID:
- 68541
- •Concept ID:
- C0231528
- •
- Sign or Symptom
Pain in muscle.
Diffuse alveolar hemorrhage- MedGen UID:
- 1381751
- •Concept ID:
- C4476767
- •
- Disease or Syndrome
A type of of pulmonary hemorrhage that originates from the pulmonary microcirculation, including the alveolar capillaries, arterioles, and venules. It presents with hemoptysis, anemia, diffuse lung infiltration, and acute respiratory failure. The diagnosis is confirmed by the observation of the accumulation of red blood cells, fibrin, or hemosiderin-laden macrophage in the alveolar space on pathologic biopsy. Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen.
Localized pulmonary hemorrhage- MedGen UID:
- 1713925
- •Concept ID:
- C5397981
- •
- Pathologic Function
Circumscribed pulmonary hemorrhage originating from a single bleeding site in the lungs. This can be due to infections, tumorigenesis, foreign bodies, or vascular abnormalities. Patient often feel the site of bleeding, contrast CT scan or angiography may localize the bleeder.
Weight loss- MedGen UID:
- 853198
- •Concept ID:
- C1262477
- •
- Finding
Reduction of total body weight.
Mononeuritis multiplex- MedGen UID:
- 101790
- •Concept ID:
- C0151295
- •
- Disease or Syndrome
A type of peripheral neuropathy that happens when there is damage to two or more different nerve areas characterized by peripheral neuropathy of both the motor and sensory nerves of at least two different nerve trunks. Different nerves are affected either simultaneously or sequentially.
Cough- MedGen UID:
- 41325
- •Concept ID:
- C0010200
- •
- Sign or Symptom
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.
Pleuritis- MedGen UID:
- 10807
- •Concept ID:
- C0032231
- •
- Disease or Syndrome
Inflammation of the pleura.
Respiratory insufficiency- MedGen UID:
- 11197
- •Concept ID:
- C0035229
- •
- Pathologic Function
Impairment of gas exchange within the lungs secondary to a disease process, neoplasm, or trauma, possibly resulting in hypoxia, hypercarbia, or both, but not requiring intubation or mechanical ventilation. Patients are normally managed with pharmaceutical therapy, supplemental oxygen, or both.
Tracheal stenosis- MedGen UID:
- 21227
- •Concept ID:
- C0040583
- •
- Disease or Syndrome
Narrowing of the lumen of the trachea.
Pulmonary infiltrates- MedGen UID:
- 116009
- •Concept ID:
- C0235896
- •
- Finding
A finding indicating the presence of an inflammatory or neoplastic cellular infiltrate in the lung parenchyma.
Subglottic stenosis- MedGen UID:
- 68668
- •Concept ID:
- C0238441
- •
- Anatomical Abnormality
Rhinorrhea- MedGen UID:
- 226777
- •Concept ID:
- C1260880
- •
- Sign or Symptom
Increased discharge of mucus from the nose.
Elevated bronchoalveolar lavage fluid neutrophil proportion- MedGen UID:
- 1710230
- •Concept ID:
- C5397969
- •
- Finding
Usually, Neutrophils make up less than 3% of all cells found in the broncho-alveloar lavage fluid. In children, standard value of neutrophils is higher depending on their age (children under the age of 5 show a maximum value of 10%). This elevated cell proportion is a sign for acute and chronic infections (HP:0012387, HP:0006538) and can be associated to specific diseases.
Hemosiderin-laden macrophages in bronchoalveolar fluid- MedGen UID:
- 1717924
- •Concept ID:
- C5397971
- •
- Finding
Hemosiderin-laden macrophages (HLM) in bronchoalveolar lavage (BAL) fluid were originally known as adiagnostic biomarker of alveolar hemorrhage, but have also been observed in idiopathic pulmonary fibrosis (IPF) with histopathological pattern of usual interstitial pneumonia (UIP).
Conjunctivitis- MedGen UID:
- 1093
- •Concept ID:
- C0009763
- •
- Disease or Syndrome
Inflammation of the conjunctiva.
Episcleritis- MedGen UID:
- 4994
- •Concept ID:
- C0014583
- •
- Disease or Syndrome
Inflammation of the episclera, a thin layer of tissue covering the white part (sclera) of the eye.
Keratitis- MedGen UID:
- 44013
- •Concept ID:
- C0022568
- •
- Disease or Syndrome
Inflammation of the cornea.
Sinusitis- MedGen UID:
- 20772
- •Concept ID:
- C0037199
- •
- Disease or Syndrome
Inflammation of the paranasal sinuses owing to a viral, bacterial, or fungal infection, allergy, or an autoimmune reaction.
Uveitis- MedGen UID:
- 52961
- •Concept ID:
- C0042164
- •
- Disease or Syndrome
Inflammation of one or all portions of the uveal tract.
Chronic otitis media- MedGen UID:
- 75751
- •Concept ID:
- C0271441
- •
- Disease or Syndrome
Chronic otitis media refers to fluid, swelling, or infection of the middle ear that does not heal and may cause permanent damage to the ear.
Granulomatosis- MedGen UID:
- 488910
- •Concept ID:
- C0521173
- •
- Disease or Syndrome
A granulomatous inflammation leading to multiple granuloma formation, which is a specific type of inflammation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity.
Perinuclear antineutrophil antibody positivity- MedGen UID:
- 1696202
- •Concept ID:
- C5139209
- •
- Laboratory or Test Result
The presence of autoantibodies in the serum that react against proteins predominantly expressed in perinuclear region of neutrophils.
Cytoplasmic antineutrophil antibody positivity- MedGen UID:
- 1690999
- •Concept ID:
- C5139210
- •
- Finding
The presence of autoantibodies in the serum that react against proteins predominantly expressed in cytoplasmic granules of neutrophils.
Fever- MedGen UID:
- 5169
- •Concept ID:
- C0015967
- •
- Sign or Symptom
Body temperature elevated above the normal range.
Oral ulcer- MedGen UID:
- 57699
- •Concept ID:
- C0149745
- •
- Disease or Syndrome
Erosion of the mucous mebrane of the mouth with local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue.
Concave nasal ridge- MedGen UID:
- 78105
- •Concept ID:
- C0264169
- •
- Finding
Nasal ridge curving posteriorly to an imaginary line that connects the nasal root and tip.
Nasal mucosa vasculitis- MedGen UID:
- 1841783
- •Concept ID:
- C5826769
- •
- Disease or Syndrome
Inflammation of blood vessels in the mucosa of the nasal cavity.
Skin ulcer- MedGen UID:
- 52369
- •Concept ID:
- C0037299
- •
- Disease or Syndrome
A discontinuity of the skin exhibiting complete loss of the epidermis and often portions of the dermis and even subcutaneous fat.
Retinal hemorrhage- MedGen UID:
- 11210
- •Concept ID:
- C0035317
- •
- Pathologic Function
Hemorrhage occurring within the retina.
- Abnormality of head or neck
- Abnormality of metabolism/homeostasis
- Abnormality of the cardiovascular system
- Abnormality of the eye
- Abnormality of the immune system
- Abnormality of the integument
- Abnormality of the nervous system
- Abnormality of the respiratory system
- Constitutional symptom
- Growth abnormality