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Late-onset neonatal sepsis

MedGen UID:
853136
•Concept ID:
C1096721
•
Disease or Syndrome
Synonyms: Late-Onset Sepses, Neonatal; Late-Onset Sepsis, Neonatal; Neonatal Late Onset Sepsis; Neonatal Late-Onset Sepses; Neonatal Late-Onset Sepsis; Sepses, Neonatal Late-Onset; Sepsis, Neonatal Late-Onset
SNOMED CT: Late-onset neonatal sepsis (765107002)

Definition

An infectious disorder of newborn infants that is characterized by a systemic inflammatory response beyond 72 hours of life and is most commonly caused by bacteria. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLate-onset neonatal sepsis

Professional guidelines

PubMed

Updates in Late-Onset Sepsis: Risk Assessment, Therapy, and Outcomes.
Coggins SA, Glaser K
Neoreviews 2022 Nov 1;23(11):738-755. doi: 10.1542/neo.23-10-e738. PMID: 36316254Free PMC Article
Efficacy of empiric antibiotic treatment of late-onset neonatal sepsis caused by Enterobacteriaceae: A systematic review.
Akselsen AB, Sheth CC, Veses V
Lett Appl Microbiol 2022 Sep;75(3):500-510. Epub 2022 Jan 7 doi: 10.1111/lam.13640. PMID: 34951709
Considerations in the pharmacologic treatment and prevention of neonatal sepsis.
Stockmann C, Spigarelli MG, Campbell SC, Constance JE, Courter JD, Thorell EA, Olson J, Sherwin CM
Paediatr Drugs 2014 Feb;16(1):67-81. doi: 10.1007/s40272-013-0057-x. PMID: 24218112

Recent clinical studies

Etiology

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Late-onset neonatal sepsis in Suzhou, China.
Pan T, Zhu Q, Li P, Hua J, Feng X
BMC Pediatr 2020 May 29;20(1):261. doi: 10.1186/s12887-020-02103-y. PMID: 32471377Free PMC Article
Late-onset neonatal sepsis: recent developments.
Dong Y, Speer CP
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F257-63. Epub 2014 Nov 25 doi: 10.1136/archdischild-2014-306213. PMID: 25425653Free PMC Article
Clinical microbiology of early-onset and late-onset neonatal sepsis, particularly among preterm babies.
Kristóf K, Kocsis E, Nagy K
Acta Microbiol Immunol Hung 2009 Mar;56(1):21-51. doi: 10.1556/AMicr.56.2009.1.2. PMID: 19388555

Diagnosis

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Late-onset neonatal sepsis in Suzhou, China.
Pan T, Zhu Q, Li P, Hua J, Feng X
BMC Pediatr 2020 May 29;20(1):261. doi: 10.1186/s12887-020-02103-y. PMID: 32471377Free PMC Article
Malignant Infantile Osteopetrosis.
Gillani S, Abbas Z
J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):350-352. PMID: 28718264
Late-onset neonatal sepsis: recent developments.
Dong Y, Speer CP
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F257-63. Epub 2014 Nov 25 doi: 10.1136/archdischild-2014-306213. PMID: 25425653Free PMC Article

Therapy

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Late-onset neonatal sepsis in Suzhou, China.
Pan T, Zhu Q, Li P, Hua J, Feng X
BMC Pediatr 2020 May 29;20(1):261. doi: 10.1186/s12887-020-02103-y. PMID: 32471377Free PMC Article
Late-onset neonatal sepsis: recent developments.
Dong Y, Speer CP
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F257-63. Epub 2014 Nov 25 doi: 10.1136/archdischild-2014-306213. PMID: 25425653Free PMC Article
Considerations in the pharmacologic treatment and prevention of neonatal sepsis.
Stockmann C, Spigarelli MG, Campbell SC, Constance JE, Courter JD, Thorell EA, Olson J, Sherwin CM
Paediatr Drugs 2014 Feb;16(1):67-81. doi: 10.1007/s40272-013-0057-x. PMID: 24218112

Prognosis

TLR2 and TLR4 expressions in late-onset neonatal sepsis: Is it a potential novel biomarker?
Rohsiswatmo R, Azharry M, Sari TT, Bahasoan Y, Wulandari D
J Neonatal Perinatal Med 2021;14(3):361-367. doi: 10.3233/NPM-200411. PMID: 33164948
Late-onset neonatal sepsis in Suzhou, China.
Pan T, Zhu Q, Li P, Hua J, Feng X
BMC Pediatr 2020 May 29;20(1):261. doi: 10.1186/s12887-020-02103-y. PMID: 32471377Free PMC Article
Malignant Infantile Osteopetrosis.
Gillani S, Abbas Z
J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):350-352. PMID: 28718264
Late-onset neonatal sepsis: recent developments.
Dong Y, Speer CP
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F257-63. Epub 2014 Nov 25 doi: 10.1136/archdischild-2014-306213. PMID: 25425653Free PMC Article
Clinical microbiology of early-onset and late-onset neonatal sepsis, particularly among preterm babies.
Kristóf K, Kocsis E, Nagy K
Acta Microbiol Immunol Hung 2009 Mar;56(1):21-51. doi: 10.1556/AMicr.56.2009.1.2. PMID: 19388555

Clinical prediction guides

The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants.
Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
TLR2 and TLR4 expressions in late-onset neonatal sepsis: Is it a potential novel biomarker?
Rohsiswatmo R, Azharry M, Sari TT, Bahasoan Y, Wulandari D
J Neonatal Perinatal Med 2021;14(3):361-367. doi: 10.3233/NPM-200411. PMID: 33164948
Late-onset neonatal sepsis in Suzhou, China.
Pan T, Zhu Q, Li P, Hua J, Feng X
BMC Pediatr 2020 May 29;20(1):261. doi: 10.1186/s12887-020-02103-y. PMID: 32471377Free PMC Article
Malignant Infantile Osteopetrosis.
Gillani S, Abbas Z
J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):350-352. PMID: 28718264

Recent systematic reviews

Diagnostic capacity of miRNAs in neonatal sepsis: a systematic review and meta-analysis.
Zhao Y, Zhu R, Hu X
J Matern Fetal Neonatal Med 2024 Dec;37(1):2345850. Epub 2024 May 7 doi: 10.1080/14767058.2024.2345850. PMID: 38714508
Efficacy of empiric antibiotic treatment of late-onset neonatal sepsis caused by Enterobacteriaceae: A systematic review.
Akselsen AB, Sheth CC, Veses V
Lett Appl Microbiol 2022 Sep;75(3):500-510. Epub 2022 Jan 7 doi: 10.1111/lam.13640. PMID: 34951709
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis.
Fleischmann C, Reichert F, Cassini A, Horner R, Harder T, Markwart R, Tröndle M, Savova Y, Kissoon N, Schlattmann P, Reinhart K, Allegranzi B, Eckmanns T
Arch Dis Child 2021 Jul 19;106(8):745-752. doi: 10.1136/archdischild-2020-320217. PMID: 33483376Free PMC Article
Candida parapsilosis is a significant neonatal pathogen: a systematic review and meta-analysis.
Pammi M, Holland L, Butler G, Gacser A, Bliss JM
Pediatr Infect Dis J 2013 May;32(5):e206-16. doi: 10.1097/INF.0b013e3182863a1c. PMID: 23340551Free PMC Article

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