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Sclerosis of hand bone

MedGen UID:
867321
•Concept ID:
C4021684
•
Disease or Syndrome
Synonyms: Generalised sclerosis of hand bones; Generalized sclerosis of hand bones; Hand bone sclerosis; Increased bone density in hand bone; Increased bone density in hand bones
 
HPO: HP:0004054

Definition

Osteosclerosis affecting one or more bones of the hand. [from HPO]

Conditions with this feature

Dysosteosclerosis
MedGen UID:
98150
•Concept ID:
C0432262
•
Disease or Syndrome
A rare genetic primary bone dysplasia disease characterized by progressive osteosclerosis and platyspondyly.
See: Condition Record
Dysosteosclerosis

Professional guidelines

PubMed

Midkine: an emerging target of drug development for treatment of multiple diseases.
Muramatsu T, Kadomatsu K
Br J Pharmacol 2014 Feb;171(4):811-3. doi: 10.1111/bph.12571. PMID: 24460672Free PMC Article
Management of Raynaud's phenomenon and digital ulcers in systemic sclerosis.
Botzoris V, Drosos AA
Joint Bone Spine 2011 Jul;78(4):341-6. Epub 2010 Dec 22 doi: 10.1016/j.jbspin.2010.11.005. PMID: 21183379
Treatment of systemic sclerosis.
Allanore Y, Kahan A
Joint Bone Spine 2006 Jul;73(4):363-8. Epub 2006 Jan 6 doi: 10.1016/j.jbspin.2005.12.003. PMID: 16495105

Recent clinical studies

Etiology

Avascular Necrosis of the Carpal Bones Other Than Kienböck Disease.
Afshar A, Tabrizi A
J Hand Surg Am 2020 Feb;45(2):148-152. Epub 2019 Oct 1 doi: 10.1016/j.jhsa.2019.05.022. PMID: 31585747
Overview of osteo-articular involvement in systemic sclerosis: Specific risk factors, clinico-sonographic evaluation, and comparison with healthy women from the French OFELY cohort.
Thietart S, Louati K, Gatfosse M, Sornay-Rendu E, Gaigneux E, Lemeunier L, Delmaire P, Riviere S, Mahevas T, Sellam J, Berenbaum F, Fain O, Roland C, Mekinian A
Best Pract Res Clin Rheumatol 2018 Aug;32(4):591-604. Epub 2019 Feb 20 doi: 10.1016/j.berh.2019.01.008. PMID: 31174827
Acro-osteolysis.
Botou A, Bangeas A, Alexiou I, Sakkas LI
Clin Rheumatol 2017 Jan;36(1):9-14. Epub 2016 Oct 29 doi: 10.1007/s10067-016-3459-7. PMID: 27796661
The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis.
Sin A, Tang W, Wen CY, Chung SK, Chiu KY
Osteoarthritis Cartilage 2015 Apr;23(4):516-24. Epub 2014 Nov 20 doi: 10.1016/j.joca.2014.11.002. PMID: 25463446
Preiser's disease.
Vidal MA, Linscheid RL, Amadio PC, Dobyns JH
Ann Chir Main Memb Super 1991;10(3):227-35. doi: 10.1016/s0753-9053(05)80287-x. PMID: 1718357

Diagnosis

Management of Raynaud's phenomenon and digital ulcers in systemic sclerosis.
Botzoris V, Drosos AA
Joint Bone Spine 2011 Jul;78(4):341-6. Epub 2010 Dec 22 doi: 10.1016/j.jbspin.2010.11.005. PMID: 21183379
Osteopoikilosis.
Ellanti P, Clarke B, Gray J
Ir J Med Sci 2010 Dec;179(4):615-6. Epub 2010 Oct 1 doi: 10.1007/s11845-010-0595-y. PMID: 20886307
Chondrocalcinosis of the wrist.
Saffar P
J Hand Surg Br 2004 Oct;29(5):486-93. doi: 10.1016/j.jhsb.2004.02.013. PMID: 15336755
Imaging and staging of avascular osteonecroses at the wrist and hand.
Schmitt R, Heinze A, Fellner F, Obletter N, Strühn R, Bautz W
Eur J Radiol 1997 Sep;25(2):92-103. doi: 10.1016/s0720-048x(97)00065-x. PMID: 9283837
Preiser's disease.
Vidal MA, Linscheid RL, Amadio PC, Dobyns JH
Ann Chir Main Memb Super 1991;10(3):227-35. doi: 10.1016/s0753-9053(05)80287-x. PMID: 1718357

Therapy

Radiographic signs of hook of hamate fracture: evaluation of diagnostic utility.
Spencer J, Hunt SL, Zhang C, Walter C, Everist B
Skeletal Radiol 2019 Dec;48(12):1891-1898. Epub 2019 May 27 doi: 10.1007/s00256-019-03221-0. PMID: 31134315
Management of Raynaud's phenomenon and digital ulcers in systemic sclerosis.
Botzoris V, Drosos AA
Joint Bone Spine 2011 Jul;78(4):341-6. Epub 2010 Dec 22 doi: 10.1016/j.jbspin.2010.11.005. PMID: 21183379
Immunomodulatory and anti-inflammatory effects of chondroitin sulphate.
du Souich P, García AG, Vergés J, Montell E
J Cell Mol Med 2009 Aug;13(8A):1451-63. Epub 2009 Jun 11 doi: 10.1111/j.1582-4934.2009.00826.x. PMID: 19522843Free PMC Article
Azathioprine for multiple sclerosis.
Casetta I, Iuliano G, Filippini G
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD003982. doi: 10.1002/14651858.CD003982.pub2. PMID: 17943809Free PMC Article
Treatment of systemic sclerosis.
Allanore Y, Kahan A
Joint Bone Spine 2006 Jul;73(4):363-8. Epub 2006 Jan 6 doi: 10.1016/j.jbspin.2005.12.003. PMID: 16495105

Prognosis

Cellular players in angiogenesis during the course of systemic sclerosis.
Cipriani P, Marrelli A, Liakouli V, Di Benedetto P, Giacomelli R
Autoimmun Rev 2011 Aug;10(10):641-6. Epub 2011 Apr 22 doi: 10.1016/j.autrev.2011.04.016. PMID: 21549220
Predictive factors of hand radiographic lesions in systemic sclerosis: a prospective study.
Avouac J, Mogavero G, Guerini H, Drapé JL, Mathieu A, Kahan A, Allanore Y
Ann Rheum Dis 2011 Apr;70(4):630-3. Epub 2010 Dec 3 doi: 10.1136/ard.2010.134304. PMID: 21131648
Treatment of systemic sclerosis.
Allanore Y, Kahan A
Joint Bone Spine 2006 Jul;73(4):363-8. Epub 2006 Jan 6 doi: 10.1016/j.jbspin.2005.12.003. PMID: 16495105
Analysis of proximal fragment sclerosis and surgical outcome of scaphoid non-union by magnetic resonance imaging.
Sakuma M, Nakamura R, Imaeda T
J Hand Surg Br 1995 Apr;20(2):201-5. doi: 10.1016/s0266-7681(05)80050-6. PMID: 7797970
Comparison of clinical, radionuclide, and radiographic features of osteoarthritis of the hands.
Macfarlane DG, Buckland-Wright JC, Emery P, Fogelman I, Clark B, Lynch J
Ann Rheum Dis 1991 Sep;50(9):623-6. doi: 10.1136/ard.50.9.623. PMID: 1929584Free PMC Article

Clinical prediction guides

A Quantitative Analysis of Subchondral Bone Density Around Osteochondritis Dissecans Lesions of the Capitellum.
Miyamura S, Lans J, Shimada K, Murase T, Chen NC
J Hand Surg Am 2022 Aug;47(8):790.e1-790.e11. Epub 2021 Aug 25 doi: 10.1016/j.jhsa.2021.06.020. PMID: 34452800
Analysis of proximal fragment sclerosis and surgical outcome of scaphoid non-union by magnetic resonance imaging.
Sakuma M, Nakamura R, Imaeda T
J Hand Surg Br 1995 Apr;20(2):201-5. doi: 10.1016/s0266-7681(05)80050-6. PMID: 7797970
Arthritis in scleroderma.
Misra R, Darton K, Jewkes RF, Black CM, Maini RN
Br J Rheumatol 1995 Sep;34(9):831-7. doi: 10.1093/rheumatology/34.9.831. PMID: 7582722
Comparison of clinical, radionuclide, and radiographic features of osteoarthritis of the hands.
Macfarlane DG, Buckland-Wright JC, Emery P, Fogelman I, Clark B, Lynch J
Ann Rheum Dis 1991 Sep;50(9):623-6. doi: 10.1136/ard.50.9.623. PMID: 1929584Free PMC Article
Preiser's disease.
Vidal MA, Linscheid RL, Amadio PC, Dobyns JH
Ann Chir Main Memb Super 1991;10(3):227-35. doi: 10.1016/s0753-9053(05)80287-x. PMID: 1718357

Recent systematic reviews

Radiographic changes of the distal phalangeal tuft of the hands in subjects with systemic sclerosis. Systematic review.
Izquierdo YE, Calvo Páramo E, Castañeda LM, Gómez SV, Zambrano FS
Reumatol Clin (Engl Ed) 2018 Jan-Feb;14(1):20-26. Epub 2016 Oct 13 doi: 10.1016/j.reuma.2016.08.009. PMID: 27746086
Azathioprine for multiple sclerosis.
Casetta I, Iuliano G, Filippini G
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD003982. doi: 10.1002/14651858.CD003982.pub2. PMID: 17943809Free PMC Article

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