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Eccrine spiradenoma

MedGen UID:
90768
•Concept ID:
C0334347
•
Neoplastic Process
Synonyms: Benign eccrine spiradenoma; Benign spiradenoma
SNOMED CT: Eccrine spiradenoma (403938001); Spiradenoma eccrine (403938001); Eccrine spiradenoma of skin (403938001); Spiradenoma (403938001); Eccrine spiradenoma (4977000); Spiradenoma (4977000)
 
Monarch Initiative: MONDO:0003448

Definition

A benign epithelial neoplasm with eccrine or apocrine differentiation, arising from the sweat glands. It usually presents as a solitary, well circumscribed, firm nodule in the face and upper trunk. It is characterized by the presence of basaloid cells forming nodules in the dermis. Cases of carcinoma arising from long standing spiradenomas have been reported. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEccrine spiradenoma

Professional guidelines

PubMed

Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.
Wagner K, Jassal K, Lee JC, Ban EJ, Cameron R, Serpell J
ANZ J Surg 2021 Oct;91(10):1996-2001. Epub 2021 Feb 1 doi: 10.1111/ans.16626. PMID: 33522696

Recent clinical studies

Etiology

Magnifying glass on spiradenoma and cylindroma histogenesis and tumorigenesis using systematic transcriptome analysis.
Bell AH, Prieto VG, Ferrarotto R, Goepfert RP, Myers JN, Weber R, Bell D
Ann Diagn Pathol 2019 Aug;41:14-23. Epub 2019 May 5 doi: 10.1016/j.anndiagpath.2019.04.015. PMID: 31128548
Eccrine spiradenoma of the nipple: Case report, differential diagnosis and literature review.
Metovic J, Gallino C, Zanon E, Bussone R, Russo R, Vissio E, Annaratone L, Conti L, Papotti M, Cassoni P, Castellano I
Histol Histopathol 2019 Aug;34(8):909-915. Epub 2019 Feb 26 doi: 10.14670/HH-18-094. PMID: 30806477
Ultrasonographic Features of Eccrine Spiradenoma.
Hwang CM, Kang BS, Hong HJ, Lee JY, Suh JH, Han EM, Song IH, Shim HS, Lee SH
J Ultrasound Med 2018 May;37(5):1267-1272. Epub 2017 Nov 9 doi: 10.1002/jum.14460. PMID: 29120034
Eccrine spiradenoma mimicking a painful traumatic neuroma: case report.
Donaldson K, Scott G, Cantor FK, Patronas NJ, Quezado M, Heiss JD
J Neurosurg 2018 Sep;129(3):825-828. Epub 2017 Oct 27 doi: 10.3171/2017.5.JNS162999. PMID: 29076781Free PMC Article
Malignant eccrine spiradenoma of the scalp.
Seyhan T, Borman H, Bal N
J Craniofac Surg 2008 Nov;19(6):1608-12. doi: 10.1097/SCS.0b013e31818b4143. PMID: 19098562

Diagnosis

Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.
Wagner K, Jassal K, Lee JC, Ban EJ, Cameron R, Serpell J
ANZ J Surg 2021 Oct;91(10):1996-2001. Epub 2021 Feb 1 doi: 10.1111/ans.16626. PMID: 33522696
Eccrine spiradenoma: A rare adnexal tumor.
Kanwaljeet S, Chatterjee T
Indian J Cancer 2017 Oct-Dec;54(4):695-696. doi: 10.4103/ijc.IJC_301_17. PMID: 30082561
Malignant eccrine spiradenoma: a meta-analysis of reported cases.
Andreoli MT, Itani KM
Am J Surg 2011 May;201(5):695-9. Epub 2010 Sep 20 doi: 10.1016/j.amjsurg.2010.04.015. PMID: 20851376
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases.
Tanese K, Sato T, Ishiko A
Clin Exp Dermatol 2010 Jan;35(1):51-5. Epub 2009 Feb 16 doi: 10.1111/j.1365-2230.2008.03072.x. PMID: 19222500
Malignant eccrine spiradenoma of the scalp.
Seyhan T, Borman H, Bal N
J Craniofac Surg 2008 Nov;19(6):1608-12. doi: 10.1097/SCS.0b013e31818b4143. PMID: 19098562

Therapy

Allergic contact dermatitis to methylisothiazolinone in hair care products: report of a case.
Gilmore R, Shan G, Katta R
Dermatol Online J 2017 Aug 15;23(8) PMID: 29469746
Malignant eccrine spiradenoma.
Mirza I, Kloss R, Sieber SC
Arch Pathol Lab Med 2002 May;126(5):591-4. doi: 10.5858/2002-126-0591-MES. PMID: 11958666

Prognosis

Eccrine spiradenoma mimicking a painful traumatic neuroma: case report.
Donaldson K, Scott G, Cantor FK, Patronas NJ, Quezado M, Heiss JD
J Neurosurg 2018 Sep;129(3):825-828. Epub 2017 Oct 27 doi: 10.3171/2017.5.JNS162999. PMID: 29076781Free PMC Article
Malignant eccrine spiradenoma: a meta-analysis of reported cases.
Andreoli MT, Itani KM
Am J Surg 2011 May;201(5):695-9. Epub 2010 Sep 20 doi: 10.1016/j.amjsurg.2010.04.015. PMID: 20851376
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases.
Tanese K, Sato T, Ishiko A
Clin Exp Dermatol 2010 Jan;35(1):51-5. Epub 2009 Feb 16 doi: 10.1111/j.1365-2230.2008.03072.x. PMID: 19222500
Malignant eccrine spiradenoma of the scalp.
Seyhan T, Borman H, Bal N
J Craniofac Surg 2008 Nov;19(6):1608-12. doi: 10.1097/SCS.0b013e31818b4143. PMID: 19098562
Low-grade malignant eccrine spiradenoma with systemic metastases.
Leonard N, Smith D, McNamara P
Am J Dermatopathol 2003 Jun;25(3):253-5. doi: 10.1097/00000372-200306000-00011. PMID: 12775989

Clinical prediction guides

Magnifying glass on spiradenoma and cylindroma histogenesis and tumorigenesis using systematic transcriptome analysis.
Bell AH, Prieto VG, Ferrarotto R, Goepfert RP, Myers JN, Weber R, Bell D
Ann Diagn Pathol 2019 Aug;41:14-23. Epub 2019 May 5 doi: 10.1016/j.anndiagpath.2019.04.015. PMID: 31128548
Skin spiradenocarcinoma - case presentation.
Rebegea LF, Firescu D, Dumitru M, Pătraşcu A
Rom J Morphol Embryol 2016;57(1):327-30. PMID: 27151731
Malignant eccrine spiradenoma: a new case report.
Ben Brahim E, Sfia M, Tangour M, Makhlouf R, Cribier B, Chatti S
J Cutan Pathol 2010 Apr;37(4):478-81. Epub 2009 Jul 10 doi: 10.1111/j.1600-0560.2009.01320.x. PMID: 19614990
De novo malignant eccrine spiradenoma with an interesting and unusual location.
Yildirim S, Aköz T, Akan M, Ege GA
Dermatol Surg 2001 Apr;27(4):417-20. doi: 10.1046/j.1524-4725.2001.00027.x. PMID: 11298720
Malignant eccrine spiradenoma of the hand.
Zamboni AC, Zamboni WA, Ross DS
J Surg Oncol 1990 Feb;43(2):131-3. doi: 10.1002/jso.2930430214. PMID: 2154644

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