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Epithelial-myoepithelial carcinoma

MedGen UID:
90776
Concept ID:
C0334392
Neoplastic Process
Synonyms: EMYOCA; Epithelial-Myoepithelial Carcinoma; epithelial-myoepithelial carcinoma
SNOMED CT: Epithelial-myoepithelial carcinoma (9618003)
 
Monarch Initiative: MONDO:0003389

Definition

A malignant neoplasm which occurs mostly in the major salivary glands (most frequently in the parotid gland), but also in the minor salivary glands of the oral mucosa and the tracheobronchial tree. It is characterized by the presence of ductal structures which are lined by an inner layer of cuboidal epithelial-type cells and an outer layer of myoepithelial cells with clear or eosinophilic cytoplasm. [from NCI]

Professional guidelines

PubMed

Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
Wockner RS, Seethala RR, Emeto TI, McCaul JA, Subramaniam SS
Int J Oral Maxillofac Surg 2023 Jan;52(1):1-12. Epub 2022 Jun 3 doi: 10.1016/j.ijom.2022.05.005. PMID: 35667947Free PMC Article
Kim BG, Lee K, Um SW, Han J, Cho JH, Kim J, Kim H, Jeong BH
Lung Cancer 2020 Aug;146:58-65. Epub 2020 May 22 doi: 10.1016/j.lungcan.2020.05.016. PMID: 32512274

Recent clinical studies

Etiology

Ramas A, Kasumovic M, Uscupsic S, Mujic M, Tokic L
Med Arch 2024;78(1):68-70. doi: 10.5455/medarh.2024.78.68-70. PMID: 38481587Free PMC Article
Suto T, Kato H, Kawaguchi M, Kobayashi K, Miyazaki T, Ando T, Noda Y, Hyodo F, Matsuo M, Ishihara H, Ogawa T
Jpn J Radiol 2022 Jun;40(6):578-585. Epub 2022 Jan 4 doi: 10.1007/s11604-021-01243-0. PMID: 34982376Free PMC Article
Nakaguro M, Tanigawa M, Hirai H, Yamamoto Y, Urano M, Takahashi RH, Sukeda A, Okumura Y, Honda S, Tasaki K, Shimizu A, Tsukahara K, Tada Y, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 Jul 1;45(7):885-894. doi: 10.1097/PAS.0000000000001673. PMID: 33481388Free PMC Article
Vázquez A, Patel TD, D'Aguillo CM, Abdou RY, Farver W, Baredes S, Eloy JA, Park RC
Otolaryngol Head Neck Surg 2015 Oct;153(4):569-74. Epub 2015 Jul 20 doi: 10.1177/0194599815594788. PMID: 26195572
Dimitrijevic MV, Tomanovic NR, Jesic SD, Arsovic NA, Mircic AL, Krstic AM
Arch Iran Med 2015 Apr;18(4):218-22. PMID: 25841941

Diagnosis

Nakaguro M, Nagao T
Surg Pathol Clin 2021 Mar;14(1):97-109. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.10.002. PMID: 33526226
Dimitrijevic MV, Tomanovic NR, Jesic SD, Arsovic NA, Mircic AL, Krstic AM
Arch Iran Med 2015 Apr;18(4):218-22. PMID: 25841941
Seethala RR
Head Neck Pathol 2013 Jul;7 Suppl 1(Suppl 1):S77-84. Epub 2013 Jul 3 doi: 10.1007/s12105-013-0461-0. PMID: 23821213Free PMC Article
Chao TY, Lin AS, Lie CH, Chung YH, Lin JW, Lin MC
Ann Thorac Surg 2007 Feb;83(2):689-91. doi: 10.1016/j.athoracsur.2006.07.025. PMID: 17258020
Ru K, Srivastava A, Tischler AS
Arch Pathol Lab Med 2004 Jan;128(1):92-4. doi: 10.5858/2004-128-92-BEC. PMID: 14692803

Therapy

Mäkelä R, Arjonen A, Suryo Rahmanto A, Härmä V, Lehtiö J, Kuopio T, Helleday T, Sangfelt O, Kononen J, Rantala JK
Neoplasia 2020 Sep;22(9):390-398. Epub 2020 Jul 6 doi: 10.1016/j.neo.2020.06.007. PMID: 32645560Free PMC Article
Zhu J, Li K, Dong X, Zhou P, Li P, Bi J
Medicine (Baltimore) 2018 Apr;97(15):e0364. doi: 10.1097/MD.0000000000010364. PMID: 29642184Free PMC Article
Kim CH, Jeong JS, Kim SR, Lee YC
Thorax 2018 Jun;73(6):593-594. Epub 2017 Dec 1 doi: 10.1136/thoraxjnl-2017-211155. PMID: 29196470Free PMC Article
Mann JM, Kellman RM, Hahn SS, de la Roza GL, Gajra A
Head Neck 2015 Aug;37(8):E96-8. Epub 2015 May 26 doi: 10.1002/hed.23873. PMID: 25242451
Zhang J, Zhen L, Zhang JG, Yu GY
Int J Oral Maxillofac Surg 2014 Dec;43(12):1431-5. Epub 2014 Sep 16 doi: 10.1016/j.ijom.2014.08.007. PMID: 25240907

Prognosis

Nakaguro M, Nagao T
Surg Pathol Clin 2021 Mar;14(1):97-109. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.10.002. PMID: 33526226
Robinson RA
Surg Pathol Clin 2021 Mar;14(1):25-42. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.005. PMID: 33526221
Nakaguro M, Tanigawa M, Hirai H, Yamamoto Y, Urano M, Takahashi RH, Sukeda A, Okumura Y, Honda S, Tasaki K, Shimizu A, Tsukahara K, Tada Y, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 Jul 1;45(7):885-894. doi: 10.1097/PAS.0000000000001673. PMID: 33481388Free PMC Article
De Cecio R, Cantile M, Fulciniti F, Botti G, Foschini MP, Losito NS
Pathologica 2017 Mar;109(1):1-8. PMID: 28635988
Dimitrijevic MV, Tomanovic NR, Jesic SD, Arsovic NA, Mircic AL, Krstic AM
Arch Iran Med 2015 Apr;18(4):218-22. PMID: 25841941

Clinical prediction guides

Ma C, Yang C, Peng A, Sun T, Ji X, Mi J, Wei L, Shen S, Feng Q
Mol Cancer 2023 Oct 13;22(1):170. doi: 10.1186/s12943-023-01876-x. PMID: 37833788Free PMC Article
Suto T, Kato H, Kawaguchi M, Kobayashi K, Miyazaki T, Ando T, Noda Y, Hyodo F, Matsuo M, Ishihara H, Ogawa T
Jpn J Radiol 2022 Jun;40(6):578-585. Epub 2022 Jan 4 doi: 10.1007/s11604-021-01243-0. PMID: 34982376Free PMC Article
Sun J, Cai X, Zou W, Zhang J
J Nippon Med Sch 2021;88(3):238-241. doi: 10.1272/jnms.JNMS.2021_88-309. PMID: 34193744
Nakaguro M, Tanigawa M, Hirai H, Yamamoto Y, Urano M, Takahashi RH, Sukeda A, Okumura Y, Honda S, Tasaki K, Shimizu A, Tsukahara K, Tada Y, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 Jul 1;45(7):885-894. doi: 10.1097/PAS.0000000000001673. PMID: 33481388Free PMC Article
Cheuk W, Chan JK
Histopathology 2007 Jul;51(1):1-20. Epub 2007 May 31 doi: 10.1111/j.1365-2559.2007.02719.x. PMID: 17539914

Recent systematic reviews

Wockner RS, Seethala RR, Emeto TI, McCaul JA, Subramaniam SS
Int J Oral Maxillofac Surg 2023 Jan;52(1):1-12. Epub 2022 Jun 3 doi: 10.1016/j.ijom.2022.05.005. PMID: 35667947Free PMC Article

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