S100A8 S100 calcium binding protein A8 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: S100A8provided by VGNC
Official Full Name: S100 calcium binding protein A8provided by VGNC
Primary source: VGNC:VGNC:92546
See related: Ensembl:ENSSSCG00000006590
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in lung (RPKM 51.7), spleen (RPKM 28.5) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	4	NC_010446.5 (96209670..96210603)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	4	NC_010446.4 (105091816..105092749, complement)

Chromosome 4 - NC_010446.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study verified porcine calprotectin (S100A8/A9) expression at the protein level in multiple Haemophilus parasuis infected tissues and explored their molecular characterization.
Title: Porcine S100A8 and S100A9: molecular characterizations and crucial functions in response to Haemophilus parasuis infection.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in leukocyte migration involved in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil aggregation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein S100-A8

Names: calprotectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160271.3 → NP_001153743.1 protein S100-A8

See identical proteins and their annotated locations for NP_001153743.1

Status: VALIDATED

Source sequence(s)

CB479318, EW341756, EW414308

UniProtKB/TrEMBL

A0A4X1VVF8, A0A8D0TYA1, C3S7K5, K7GQW2

Related

ENSSSCP00000030286.2, ENSSSCT00000036517.4

Conserved Domains (2) summary

pfam13499
Location:29 → 75

EF-hand_7; EF-hand domain pair

cl08302
Location:3 → 86

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...