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Aatf Apoptosis antagonizing transcription factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33943, updated on 2-Nov-2024

Summary

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Official Symbol
Aatfprovided by FlyBase
Official Full Name
Apoptosis antagonizing transcription factorprovided by FlyBase
Primary source
FLYBASE:FBgn0031851
Locus tag
Dmel_CG11188
See related
AllianceGenome:FB:FBgn0031851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AATF; anon-WO0118547.190; CG11188; Che-1; Dmel\CG11188; nutmeg
Summary
Involved in negative regulation of programmed cell death and oogenesis. Located in nucleolus. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Used to study chromosome 17q12 deletion syndrome. Orthologous to human AATF (apoptosis antagonizing transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Aatf in Genome Data Viewer
Location:
27A1-27A1; 2-22 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6717625..6719389)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6717625..6719389)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Thrombospondin Neighboring gene Adipokinetic hormone receptor Neighboring gene homer Neighboring gene Liprin-alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis. Bharucha KN, et al. J Exp Biol, 2008 Oct. PMID 18805809, Free PMC Article
  2. Dual lipolytic control of body fat storage and mobilization in Drosophila. Grönke S, et al. PLoS Biol, 2007 Jun. PMID 17488184, Free PMC Article
  3. A mosaic genetic screen for genes involved in the early steps of Drosophila oogenesis. Jagut M, et al. G3 (Bethesda), 2013 Mar. PMID 23450845, Free PMC Article
  4. Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development. Yusuff T, et al. PLoS Genet, 2020 Jun. PMID 32579612, Free PMC Article
  5. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
apoptosis antagonizing transcription factor
Names
Aatf-PA
CG11188-PA
apoptosis antagonizing transcription factor ortholog
nutmeg

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6717625..6719389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135222.3 → NP_609066.1  apoptosis antagonizing transcription factor [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609066.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VM95
    Related
    FBpp0078929
    Conserved Domains (2) summary
    pfam08164
    Location:405 → 487
    TRAUB; Apoptosis-antagonizing transcription factor, C-terminal
    pfam13339
    Location:211 → 337
    AATF-Che1; Apoptosis antagonizing transcription factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VM95.1 Q9VM95

Gene LinkOut

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Chemical Information
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