porin porin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: porinprovided by FlyBase
Official Full Name: porinprovided by FlyBase
Primary source: FLYBASE:FBgn0004363
Locus tag: Dmel_CG6647
See related: AllianceGenome:FB:FBgn0004363
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO02059370.56; cg6647; CG6647; Dmel\CG6647; DmPorin1; DmVDAC; DVDAC; l(2)k05123; POR-1; Porin; PORIN; Vdac; VDAC; Vdac1; VDAC1
Summary: Enables voltage-gated monoatomic anion channel activity. Involved in several processes, including negative regulation of calcium import into the mitochondrion; sperm individualization; and sperm mitochondrion organization. Located in Nebenkern and mitochondrion. Is active in mitochondrial outer membrane. Is expressed in several structures, including follicle cell; gonad; head epidermis primordium; mesoderm; and visceral muscle primordium. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including VDAC1 (voltage dependent anion channel 1) and VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 32B1-32B1; 2-43 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10847227..10850848, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10847227..10850848, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The inhibition of porin phenocopies Parkinson disease phenotypes in Drosophila, while the overexpression of Buffy can counteract these phenotypes to improve the overall "healthspan" of the organism.
Title: Loss of porin function in dopaminergic neurons of Drosophila is suppressed by Buffy.
Drosophila porin mutants have a role in mitochondrial dysfunction and disease
Title: Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease.
Porin isoform 1 is selectively targeted to follicular cells while Porin isoform 2 is present in mitochondria of the epithelial sheath cells of the ovariole.
Title: Porin isoform 2 has a different localization in Drosophila melanogaster ovaries than porin 1.
Our data suggest that the PORIN protein is important in maintaining a photoreceptor response during prolonged stimulation.
Title: Effects of a mutation in the Drosophila porin gene encoding mitochondrial voltage-dependent anion channel protein on phototransduction.
identification of two PlacW insertions in the porin gene among a set of P-element insertions that have been mapped to the 32B3-4 region on the second chromosome
Title: A genetic analysis of the porin gene encoding a voltage-dependent anion channel protein in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic anion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcium import into the mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Nebenkern	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: porin

Names: CG6647-PA; CG6647-PB; CG6647-PC; CG6647-PD; CG6647-PE; VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL; mitochondrial porin; porin 1; porin-PA; porin-PB; porin-PC; porin-PD; porin-PE; voltage-dependent anion channel

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10847227..10850848 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_134283.2 → NP_599110.1 porin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599110.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q29QZ3, Q94920, Q94997, Q9VKP1

UniProtKB/TrEMBL

M9PD75

Related

FBpp0079772, FBtr0080183

Conserved Domains (1) summary

cd07306
Location:3 → 281

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
NM_001259032.1 → NP_001245961.1 porin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245961.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q29QZ3, Q94920, Q94997, Q9VKP1

UniProtKB/TrEMBL

M9PD75

Conserved Domains (1) summary

cd07306
Location:3 → 281

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
NM_001273436.1 → NP_001260365.1 porin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260365.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q29QZ3, Q94920, Q94997, Q9VKP1

UniProtKB/TrEMBL

M9PD75

Conserved Domains (1) summary

cd07306
Location:3 → 281

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
NM_001038810.2 → NP_001033899.1 porin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001033899.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q29QZ3, Q94920, Q94997, Q9VKP1

UniProtKB/TrEMBL

M9PD75

Conserved Domains (1) summary

cd07306
Location:3 → 281

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
NM_057465.4 → NP_476813.1 porin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476813.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q29QZ3, Q94920, Q94997, Q9VKP1

UniProtKB/TrEMBL

M9PD75

Related

FBpp0079771

Conserved Domains (1) summary

cd07306
Location:3 → 281

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane