U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mwh multiple wing hairs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38131, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
mwhprovided by FlyBase
Official Full Name
multiple wing hairsprovided by FlyBase
Primary source
FLYBASE:FBgn0264272
Locus tag
Dmel_CG43772
See related
AllianceGenome:FB:FBgn0264272
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BP1018; CG13913; CG34022; CG43772; Dmel\CG43772; Mwh
Old locus tag
Dmel_CG13913; Dmel_CG34022
Summary
Predicted to enable actin filament binding activity. Involved in imaginal disc-derived wing hair site selection and negative regulation of actin filament polymerization. Predicted to be active in cytosol. Is expressed in several structures, including dorsal epidermis primordium; embryonic head epidermis; embryonic ventral epidermis; epidermis; and wing. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mwh in Genome Data Viewer
Location:
61F3-61F4; 3-0 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1200786..1232700)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1200786..1232700)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Lysozyme X Neighboring gene APPL-interacting protein 1 Neighboring gene meep Neighboring gene uncharacterized protein Neighboring gene Lysozyme B Neighboring gene Lysozyme C Neighboring gene Lysozyme D Neighboring gene Lysozyme E Neighboring gene Lysozyme P Neighboring gene Lysozyme S Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Stages of cell hair construction in Drosophila. Mitchell HK, et al. Dev Genet, 1990. PMID 2116250
  2. [Further research on model growth in combination with partly dissociated wing imaginal disks of Drosophila melanogaster]. URSPRUNG H, et al. Dev Biol, 1962 Feb. PMID 13923941
  3. High-throughput in vivo genotoxicity testing: an automated readout system for the somatic mutation and recombination test (SMART). Lombardot B, et al. PLoS One, 2015. PMID 25830368, Free PMC Article
  4. Differentiation capacities of the dorsal metathoracic (haltere) disc ofDrosophila melanogaster : I. Normal organ map. Ouweneel WJ, et al. Wilhelm Roux Arch Entwickl Mech Org, 1973 Jun. PMID 28304588
  5. [The manifestation pattern of the mutant "multiple wing hairs" (mwh) of Drosophila melanogaster]. Peyer B, et al. Arch Julius Klaus Stift Vererbungsforsch Sozialanthropol Rassenhyg, 1965. PMID 5294131

See all (263) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms.
    Title: Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms.
  2. Cmb (Combover) is a novel planar cell polarity effector that promotes to wing hair formation, a function that is antagonized by Mwh.
    Title: Combover/CG10732, a novel PCP effector for Drosophila wing hair formation.
  3. multiple-wing-hairs gene encodes a novel GBD-FH3 domain-containing protein that functions both prior to and after wing hair initiati
    Title: The multiple-wing-hairs gene encodes a novel GBD-FH3 domain-containing protein that functions both prior to and after wing hair initiation.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: 1219647-1227237 mobile_element_type = transposon:412{}904

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of planar polarity TAS
Traceable Author Statement
more info
 PubMed 
involved_in imaginal disc-derived wing hair organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing hair site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
multiple wing hairs
Names
CG43772-PA
CG43772-PB
CG43772-PC
multiple wing hair
multiple-wing-hairs
mwh-PA
mwh-PB
mwh-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1200786..1232700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274315.1 → NP_001261244.1  multiple wing hairs, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261244.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PE53
    Conserved Domains (2) summary
    pfam06367
    Location:524 → 725
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:380 → 506
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. NM_001274314.1 → NP_001261243.1  multiple wing hairs, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261243.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDL4
    Conserved Domains (2) summary
    pfam06367
    Location:523 → 724
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:379 → 505
    Drf_GBD; Diaphanous GTPase-binding Domain

  3. NM_138238.3 → NP_612082.1  multiple wing hairs, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612082.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0J2
    Related
    FBpp0303809
    Conserved Domains (2) summary
    pfam06367
    Location:291 → 492
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:147 → 273
    Drf_GBD; Diaphanous GTPase-binding Domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDL4 M9PDL4
M9PE53 M9PE53
Q9W0J2 Q9W0J2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous