psma8 proteasome 20S subunit alpha 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psma8provided by ZNC
Official Full Name: proteasome 20S subunit alpha 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2194
See related: Ensembl:ENSDARG00000010965 AllianceGenome:ZFIN:ZDB-GENE-040426-2194
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: psma7; zgc:77139; wu:fk28c01
Summary: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, alpha-subunit complex. Predicted to be active in nucleus. Orthologous to human PSMA8 (proteasome 20S subunit alpha 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (18306122..18313835, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (18406539..18414252, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fk28c01.x1 (e-PCR)
- UniSTS:200745

AI384314 (e-PCR)
- UniSTS:206732

fi47f08.x1 (e-PCR)
- UniSTS:197605

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome subunit alpha-type 8

Names: proteasome (prosome, macropain) subunit, alpha type, 8; proteasome subunit alpha 8

NP_998331.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213166.1 → NP_998331.1 proteasome subunit alpha-type 8

See identical proteins and their annotated locations for NP_998331.1

Status: PROVISIONAL

Source sequence(s)

BC065608

UniProtKB/TrEMBL

A0A8M1PIY4, Q6P0I2

Related

ENSDARP00000006445.5, ENSDART00000015479.7

Conserved Domains (1) summary

cd03755
Location:5 → 213

proteasome_alpha_type_7; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...