fkh fork head [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fkhprovided by FlyBase
Official Full Name: fork headprovided by FlyBase
Primary source: FLYBASE:FBgn0000659
Locus tag: Dmel_CG10002
See related: AllianceGenome:FB:FBgn0000659
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10002; dFoxA; Dm-FoxA; Dmel\CG10002; Dmfkh; Fkh; FKH; FoxA; Sebp2
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including DNA endoreduplication; autophagic cell death; and determination of adult lifespan. Located in nucleus. Is expressed in several structures, including CNS glial cell; epithelium; gut section; head epidermis primordium; and primary neurons. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including FOXA2 (forkhead box A2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 98D5-98D5; 3-96 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (28580976..28585264, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24406698..24410986, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptome profiling identifies multistep regulation through E93, Forkhead and Ecdysone Oxidase in survival of Malpighian tubules during metamorphosis in Drosophila.
Title: Transcriptome profiling identifies multistep regulation through E93, Forkhead and Ecdysone Oxidase in survival of Malpighian tubules during metamorphosis in Drosophila.
Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting.
Title: Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting.
Differentially Expressed Long Noncoding RNAs in the Promoter Region of the fork head Gene in Drosophila melanogaster Detected by Northern Blot Hybridization
Title: [Differentially Expressed Long Noncoding RNAs in the Promoter Region of the fork head Gene in Drosophila melanogaster Detected by Northern Blot Hybridization].
FKH in the gut in mediating anti-aging effects of reduced insulin/insulin growth factor.
Title: Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity.
Fkh maintains the expression of stem/progenitor cell markers and is required for stem cell proliferation during intestinal homeostasis and regeneration.It prevents intestinal stem/progenitor cells from precocious differentiation into the enterocyte lineage, likely in cooperation with bHLH/Daughterless. Its loss suppresses the intestinal tumorigenesis caused by Notch pathway inactivation.
Title: FoxA transcription factor Fork head maintains the intestinal stem/progenitor cell identities in Drosophila.
controls activation of Dpt and Mtk
Title: Forkhead, a new cross regulator of metabolism and innate immunity downstream of TOR in Drosophila.
Sage, a bHLH transcription factor expressed exclusively in the Drosophila salivary gland (SG), is required for late SG survival and normal tube morphology and provides tissue specificity to FoxA
Title: Organ-specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA.
Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin
Title: The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin.
Mapping of potential trithorax-associated regulatory elements within the extended (9 kb) promoter region of the fork head gene (fkh) in the Drosophila melanogaster salivary gland cells was performed.
Title: [Immunoprecipitation mapping of the TRX-associated chromosome elements in the fork head gene promoter in the Drosophila melanogaster salivary gland cells].
Fkh cooperates with the salivary gland-specific bHLH protein Sage to directly regulate expression of PH4alphaSG2, as well as sage itself, and to indirectly regulate expression of PH4alphaSG1.
Title: Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagic cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoderm formation	TAS Traceable Author Statement more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in neuroendocrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fork head

Names: CG10002-PA; CG10002-PB; CG10002-PC; CG10002-PD; CG10002-PE; fkh-PA; fkh-PB; fkh-PC; fkh-PD; fkh-PE; fork head, which is crucial for survival, is enriched in the MT transcriptome, and its down regulation in; forkhead; secretion enhancer-binding protein 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

28580976..28585264 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300645.1 → NP_001287574.1 fork head, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287574.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P14734, Q9VAV0

UniProtKB/TrEMBL

E1JJ07, Q32KE3

Conserved Domains (2) summary

smart00339
Location:210 → 298

FH; FORKHEAD

pfam08430
Location:120 → 209

Forkhead_N; Forkhead N-terminal region
NM_001170291.1 → NP_001163762.1 fork head, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163762.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P14734, Q9VAV0

UniProtKB/TrEMBL

E1JJ07, Q32KE3

Conserved Domains (2) summary

smart00339
Location:210 → 298

FH; FORKHEAD

pfam08430
Location:120 → 209

Forkhead_N; Forkhead N-terminal region
NM_001276109.1 → NP_001263038.1 fork head, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263038.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHC0

Conserved Domains (2) summary

smart00339
Location:210 → 298

FH; FORKHEAD

pfam08430
Location:120 → 209

Forkhead_N; Forkhead N-terminal region
NM_001316532.1 → NP_001303461.1 fork head, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GV17, Q32KE3

Conserved Domains (2) summary

smart00339
Location:210 → 298

FH; FORKHEAD

pfam08430
Location:120 → 209

Forkhead_N; Forkhead N-terminal region
NM_079818.3 → NP_524542.1 fork head, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524542.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P14734, Q9VAV0

UniProtKB/TrEMBL

E1JJ07, Q32KE3

Related

FBpp0084690

Conserved Domains (2) summary

smart00339
Location:210 → 298

FH; FORKHEAD

pfam08430
Location:120 → 209

Forkhead_N; Forkhead N-terminal region