Ucn3 urocortin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ucn3provided by MGI
Official Full Name: urocortin 3provided by MGI
Primary source: MGI:MGI:1932970
See related: Ensembl:ENSMUSG00000044988 AllianceGenome:MGI:1932970
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ucn III
Summary: This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. The pancreatic islets isolated from mice lacking the encoded protein secrete less insulin in response to high glucose concentrations. Transgenic mice overexpressing the encoded protein exhibit a metabolically favorable phenotype resisting obesity and hyperglycemia on a high-fat diet. [provided by RefSeq, Sep 2016]
Expression: Biased expression in duodenum adult (RPKM 1.4), small intestine adult (RPKM 0.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A1; 13 2.2 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (3990688..3995349, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (3940688..3945349, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Urocortin 3 overexpression reduces ER stress and heat shock response in 3T3-L1 adipocytes.
Title: Urocortin 3 overexpression reduces ER stress and heat shock response in 3T3-L1 adipocytes.
Urocortin 3 contributes to paracrine inhibition of islet alpha cells in mice.
Title: Urocortin 3 contributes to paracrine inhibition of islet alpha cells in mice.
Posterodorsal Medial Amygdala Urocortin-3, GABA, and Glutamate Mediate Suppression of LH Pulsatility in Female Mice.
Title: Posterodorsal Medial Amygdala Urocortin-3, GABA, and Glutamate Mediate Suppression of LH Pulsatility in Female Mice.
Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System.
Title: Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System.
Urocortin3 in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice.
Title: Urocortin3 in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice.
Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression.
Title: Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression.
Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise-induced threshold shift.
Title: Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise-induced threshold shift.
Urocortin 3, the newest member of corticotrophin releasing hormone family polypeptides, is an anorexic factor, which has a strong inhibitory effect on animal appetite regulation. (Review)
Title: Progress in understanding the roles of Urocortin3 (UCN3) in the control of appetite from studies using animal models.
findings collectively suggest that the MeA Ucn3-CRF-R2 system modulates the ability of mice to cope with social challenges
Title: Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics.
Ucn3 KO mice displayed significantly increased ethanol intake and preference compared with WT. There were no long-term effects of chronic pain on alcohol drinking behavior, regardless of genotype.
Title: Increased alcohol consumption in urocortin 3 knockout mice is unaffected by chronic inflammatory pain.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables corticotropin-releasing hormone receptor 2 binding	IEA Inferred from Electronic Annotation more info
enables corticotropin-releasing hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuropeptide signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in response to corticosterone	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to immobilization stress	IEA Inferred from Electronic Annotation more info
involved_in response to starvation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in varicosity	IEA Inferred from Electronic Annotation more info
located_in varicosity	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: urocortin-3

Names: Urocortin III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.