INADVERTENT GLOBE PENETRATION AND SUBRETINAL INJECTION OF BOTULINUM TOXIN IN A PATIENT WITH OCULOCUTANEOUS ALBINISM

Retin Cases Brief Rep. 2023 May 1;17(3):302-304. doi: 10.1097/ICB.0000000000001160.

Abstract

Purpose: To present a case of localized retinal detachment and mild vitreous hemorrhage in a patient with oculocutaneous albinism after accidental intraocular injection of botulinum toxin A.

Methods: Botulinum toxin A injection was administered to a 5-year-old patient with oculocutaneous albinism with esotropia and resulted in an ocular penetration. Dilated fundus examination indicated a nasal retinal tear causing a mild vitreous hemorrhage and a localized retinal detachment.

Results: No treatment was required for the retinal detachment, and we observed the patient at regular intervals. On Day 1, the detachment resolved spontaneously without sequelae. On follow-up, scarring at the lesion site was detected at one month after the incidence, and the patient's vision was stable.

Conclusion: In this instance, observation was sufficient for our patient with complete resolution of retinal detachment and no long-term complication. Botulinum toxin A did not seem toxic to intraocular tissues. However, intramuscular botulinum toxin A injection should be administered carefully. Oculocutaneous albinism did not seem to affect the final outcome in our case.

Publication types

  • Case Reports

MeSH terms

  • Albinism, Oculocutaneous* / complications
  • Botulinum Toxins, Type A*
  • Child, Preschool
  • Eye Injuries, Penetrating*
  • Humans
  • Injections, Intraocular / adverse effects
  • Retinal Detachment* / diagnosis
  • Vitreous Hemorrhage / complications

Substances

  • Botulinum Toxins, Type A